Results 91 to 100 of about 414,419 (312)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano +11 more
wiley +1 more source
Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann +17 more
wiley +1 more source
First genome-wide association study on anxiety-related behaviours in childhood [PDF]
, 2013 Background: Twin studies have shown that anxiety in a general population sample of children involves both domain-general and trait-specific genetic effects.
Hanscombe, K.B. +66 more
core +1 more source
Molecular Therapy: Oncolytics, 2015 Progress for improving outcomes in pediatric patients with solid tumors remains slow. In addition, currently available therapies are fraught with numerous side effects, often causing significant life-long morbidity for long-term survivors.
Timothy P Cripe +12 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen +7 more
wiley +1 more source
Parent's guide to childhood immunizations [PDF]
3rd Reprint 08/14CS250472Part 1: Vaccine-preventable diseases and childhood vaccines -- Part 2: The immunization office visit -- Part 3: More about vannines -- Part 4: Frequently asked questions -- Part 5: Summary of childhood vaccine preventable ...
core +6 more sources
Childhood developmental vulnerabilities associated with early life exposure to infectious and noninfectious diseases and maternal mental illness [PDF]
, 2017 Background: Fetal exposure to infectious and noninfectious diseases may influence early childhood developmental functioning, on the path to later mental illness.
Kristin R. Laurens +20 more
core +2 more sources
Molecular Therapy: Oncolytics, 2017 Pediatric brain tumors including medulloblastoma and atypical teratoid/rhabdoid tumor are associated with significant mortality and treatment-associated morbidity.
Adam W. Studebaker +6 more
doaj +1 more source
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
The Impact of Childhood Health on Adult Labor Market Outcomes [PDF]
This paper uses some unique data derived from the Panel Survey of Income Dynamics that has followed groups of siblings and their parents for as long as thirty years.
James Smith
core +3 more sources