Results 71 to 80 of about 13,455 (285)

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Biofilm infection of a central venous port-catheter caused by Mycobacterium avium complex in an immunocompetent child with cystic fibrosis

BMC Infectious Diseases, 2022
Background Mycobacterium (M.) chimaera is a non-tuberculous mycobacterium (NTM) that belongs to M. avium complex (MAC). In patients with cystic fibrosis (CF), MAC can cause bronchopulmonary infections that can be prolonged and difficult to treat.
Alexandra Kavvalou, Florian Stehling, Eva Tschiedel, Jan Kehrmann, Bernd Walkenfort, Mike Hasenberg, Margarete Olivier, Mathis Steindor   +7 more
doaj   +1 more source

MYOCARDIAL STRUCTURE AND VASCULARIZATION OF THE HEART VENTRICLE IN HOLOCEPHALI: IMPLICATIONS FOR HEART EVOLUTION [PDF]

, 2013
El resumen aparece en el Program & Abstracts of the 10th International Congress of Vertebrate Morphology, Barcelona 2013. Anatomical Record, Volume 296, Special Feature — 1: P-075.It has been classically assumed that the ventricle of the primitive ...
Durán, Ana C., Fernández, Borja, Lorenzale, Miguel, López-Unzu, Miguel A., Rodríguez, Cristina, Sans-Coma, Valentin   +5 more
core  

The Efficiency of the Assay for Haemopietic Colony Forming Cells [PDF]

, 1970
The quantitative efficiency of the spleen colony assay in mice is discussed in the light of recent findings on the kinetics of colony forming cells. Arguments are presented showing that the f factor, the 2 hr CFU recovery fraction in the spleen, markedly
Keizer, H.J., Lahiri, S.K., Putten, L.M.v. (L. M. van)   +2 more
core   +1 more source

Stem cells and interspecies chimaeras [PDF]

Nature, 2016
Chimaeras are both monsters of the ancient imagination and a long-established research tool. Recent advances, particularly those dealing with the identification and generation of various kinds of stem cells, have broadened the repertoire and utility of mammalian interspecies chimaeras and carved out new paths towards understanding fundamental biology ...
Wu, Jun, Greely, Henry T., Jaenisch, Rudolf, Nakauchi, Hiromitsu, Rossant, Janet, Belmonte, Juan Carlos Izpisua   +5 more
openaire   +4 more sources

Rheumatologic Manifestations of Patients With Type B Insulin Resistance

Arthritis Care &Research, EarlyView.
Objective The objectives of this study were to identify laboratory and clinical features associated with type B insulin resistance (TBIR), a rare condition caused by autoantibodies that inhibit the insulin receptor, most frequently occurring in the setting of systemic lupus erythematosus (SLE), and to increase awareness of this rare, life‐threatening ...
S. Amara Ogbonnaya, Sandra G. Williams, Raphael A. Kirou, Marissa Lightbourne, Rebecca J. Brown   +4 more
wiley   +1 more source

Mycobacterium chimaera pulmonary infection complicating cystic fibrosis: a case report

Journal of Medical Case Reports, 2011
Background Mycobacterium chimaera is a recently described species within the Mycobacterium avium complex. Its pathogenicity in respiratory tract infection remains disputed.
Rolain Jean-Marc, Dubus Jean-Christophe, Stremler Nathalie, David Marion, Cohen-Bacrie Stéphan, Drancourt Michel   +5 more
doaj   +1 more source

A framework for FPGA functional units in high performance computing [PDF]

, 2010
FPGAs make it practical to speed up a program by defining hardware functional units that perform calculations faster than can be achieved in software. Specialised digital circuits avoid the overhead of executing sequences of instructions, and they make
Koltes, A., O'Donnell, J.T.
core   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Survival of glucose phosphate isomerase null somatic cells and germ cells in adult mouse chimaeras

Biology Open, 2016
The mouse Gpi1 gene encodes the glycolytic enzyme glucose phosphate isomerase. Homozygous Gpi1−/− null mouse embryos die but a previous study showed that some homozygous Gpi1−/− null cells survived when combined with wild-type cells in fetal chimaeras ...
Margaret A. Keighren, Jean H. Flockhart, John D. West   +2 more
doaj   +1 more source