Results 131 to 140 of about 41,598 (274)

Blocking heterochromatin spreading constrains cohesin binding at a yeast heterochromatic locus. [PDF]

PLoS One
Kraycer PM, Gartenberg MR.
europepmc   +1 more source

Cellular and genetic analysis of a chimera in dizygote twins

Major Histocompatibility Complex, 2003
M Atoh, K Kobayashi, H Suzuki, Y Suzuki, T Kaneko, Xxxxx Xxxxx, S Ishigami, Y Fukuda, S Tamai   +8 more
openaire   +2 more sources

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Allostery between Distant Structural Regions Dictates Selectivity in GPCR:G Protein Coupling. [PDF]

Biochemistry
Mukhaleva E, Sánchez Rivas EJ, Branciamore S, Rodin AS, Sivaramakrishnan S, Vaidehi N.   +5 more
europepmc   +1 more source

Review Of Introduction To Biometrical Genetics By K. Mather And J. L. Jinks [PDF]

, 1979
Jenkins, John B.
core   +1 more source

Recovery of an African horsesickness virus VP2 chimera using reverse genetics

, 2016
MSc (Biochemistry), North-West University, Potchefstroom Campus, 2016 African horsesickness (AHS) is a devastating disease which causes mortality in more than 95% of fully susceptible horses. There are nine serotypes of the etiological agent, African horsesickness virus (AHSV) exhibiting different levels of cross protection.
openaire   +1 more source

One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy

Advanced Science, EarlyView.
This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu, Ben Huang, Lingyan Wang, Qiang Guo, Cuiping Jiang, Ruicheng Qi, Shuyao Wang, Lin‐Tai Da, Wenjie Peng   +8 more
wiley   +1 more source

46,XY/46,XY Chimerism: Prenatal Presentation and Postnatal Outcome. [PDF]

Mol Genet Genomic Med
Baqri W, Goh ES, Berndl A, Seesahai J, Skidmore M, Vaags AK, Kekis M.   +6 more
europepmc   +1 more source

Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits

Advanced Science, EarlyView.
A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu, Mei Yuan, Li‐Juan Tang, Fenglin Wang, Xia Chu, Jian‐Hui Jiang   +5 more
wiley   +1 more source