Results 151 to 160 of about 41,598 (274)

In Silico Functional and Structural Analysis of STAT4 Variants of Uncertain Significance. [PDF]

Genes (Basel)
Bravo-Villagra KM, Maciel-Cruz EJ, Martínez-Contreras RM, Gutiérrez-Hurtado IA, Vizcaíno-Quirarte AM, Muñoz-Valle JF, López-Quintero A.   +6 more
europepmc   +1 more source

Investigating Phase Separation in Genome Folding via Multiscale Computational Modeling

Advanced Science, EarlyView.
Phase separation is emerging as a multiscale organizing principle of genome folding across scales, from nucleosomes and transcriptional condensates to chromatin domains and nuclear compartments. By integrating physics‐based simulations with data‐driven inference, computational modeling now links molecular interactions to nuclear architecture and points
Jiahu Tang, Cibo Feng, Haibin Su, Xiakun Chu   +3 more
wiley   +1 more source

Fundamental Challenges, Physical Implementations, and Integration Strategies for Ising Machines in Large‐Scale Optimization Tasks

Advanced Electronic Materials, EarlyView.
Ising machines are emerging as specialized hardware solvers for computationally hard optimization problems. This review examines five major platforms—digital CMOS, analog CMOS, emerging devices, coherent optics, and quantum systems—highlighting physics‐rooted advantages and shared bottlenecks in scalability and connectivity.
Hyunjun Lee, Joon Pyo Kim, Sanghyeon Kim
wiley   +1 more source

Novel <i>FRMD6::PTH</i> chimera in tumorous bone lesion carrying a t(4;11;14;12)(q35;p15;q22;q13). [PDF]

Pathol Oncol Res
Panagopoulos I, Andersen K, Lloret I, Gorunova L, Lobmaier I.   +4 more
europepmc   +1 more source

AI Guided Protein Design for Next‐Generation Autogenic Engineered Living Materials

Advanced Intelligent Systems, EarlyView.
Autogenic engineered living materials (ELMs) integrate biology and materials science to create self‐regenerating and self‐healing materials. This perspective highlights emerging strategies in protein engineering and AI‐guided de novo design to expand the capabilities of autogenic ELMs.
Hoda M. Hammad, Anna M. Duraj‐Thatte
wiley   +1 more source

Targeting Glioblastoma Stem Cells: A40s Aptamer-NIR-Dye Conjugate for Glioblastoma Visualization and Treatment. [PDF]

Biomolecules
Affinito A, Ingenito F, Verde S, Musella E, Pattanayak B, Fiore D, Quintavalle C, Fraticelli A, Mascolo M, Petrillo G, Pignataro C, De Luca G, Mezzanotte L, Condorelli G.   +13 more
europepmc   +1 more source

Integrating Artificial Intelligence With Droplet‐Based Microfluidics: Advances, Challenges, and Emerging Opportunities

Advanced Intelligent Systems, EarlyView.
Droplet‐based microfluidics enables precise, high‐throughput microscale reactions but continues to face challenges in scalability, reproducibility, and data complexity. This review examines how artificial intelligence enhances droplet generation, detection, sorting, and adaptive control and discusses emerging opportunities for clinical and industrial ...
Junyan Lai, Sukrit Gaira, Rongfeng Wang, Qingtian Zhang, Ming Li, Liao Wu, Diangeng Li, Yi Li, Chengchen Zhang, Jinhong Guo, Shi‐Yang Tang   +10 more
wiley   +1 more source

African pygmy mouse iPSCs as a model for in vitro embryogenesis, interspecies chimerism, and blastocyst complementation. [PDF]

Cell Rep Methods
Gjonlleshaj P, Lenardič A, Tarnowska-Sengül M, Taborsky D, Trautmann CL, Agostinho de Sousa J, Bundschuh N, Veyrunes F, Sendoel A, Bar-Nur O.   +9 more
europepmc   +1 more source

Bayesian Optimisation for the Experimental Sciences: A Practical Guide to Data‐Efficient Optimisation of Laboratory Workflows

Advanced Intelligent Systems, EarlyView.
This study provides an introduction to Bayesian optimisation targeted for experimentalists. It explains core concepts, surrogate modelling, and acquisition strategies, and addresses common real‐world challenges such as noise, constraints, mixed variables, scalability, and automation.
Chuan He, Martin Singull, T. Jesper Jacobsson   +2 more
wiley   +1 more source

Leaf Organogenesis Improves Recovery of Solid Polyploid Shoots from Chimeric Southern Highbush Blueberry. [PDF]

BioTech (Basel)
Walter E, Biswal A, Ozias-Akins P, Chu Y.   +3 more
europepmc   +1 more source