Results 171 to 180 of about 41,598 (274)

Multiplexed Tandem Mass Spectrometry Imaging Enables Large‐Scale Isomer Mapping and Annotation in Tissues

Angewandte Chemie, EarlyView.
Parallel mass spectrometry imaging acquires high mass resolution and tandem mass spectrometry images from 108 isolation windows in a single run. Spatial similarity networking clusters product ions by spatial distribution, enabling annotation of isomers and isobars as demonstrated for phospholipids and oxidized cholesterol in mouse and human brain ...
Varun V. Sharma, Gabor Toth, Robert Martinis, Cathrin E. Hansen, Gijs Kooij, Ingela Lanekoff   +5 more
wiley   +2 more sources

HAPP: High-accuracy pipeline for processing deep metabarcoding data. [PDF]

PLoS Comput Biol
Sundh J, Granqvist E, Iwaszkiewicz-Eggebrecht E, Manoharan L, van Dijk LJA, Goodsell R, Godeiro NN, Bellini BC, Orsholm J, Łukasik P, Miraldo A, Roslin T, Tack AJM, Andersson AF, Ronquist F.   +14 more
europepmc   +1 more source

Enhanced Sensitivity of a Modified Quaking‐Induced Conversion Diagnostic Test for the Broad Detection of Sporadic and Inherited Prion Diseases: A Retrospective Study

Annals of Neurology, EarlyView.
Objective Quaking‐induced conversion (QuIC) tests, which detect prion‐seeding activity in cerebrospinal fluid (CSF), have markedly advanced the antemortem diagnosis of prion diseases such as Creutzfeldt‐Jakob disease (CJD). These tests provide high diagnostic accuracy and enable timely differentiation from other rapidly progressive neurodegenerative ...
Jennifer Myskiw, Rebecca Fox, Dominic M.S. Kielich, Lise Lamoureux, Melanie Leonhardt, Olivia Nykvist, Jessy A. Slota, Kristen Avery, Clark Phillipson, Kathy Frost, Sharon Simon, Brian S. Appleby, Ben A. Bailey‐Elkin, Stephanie A. Booth   +13 more
wiley   +1 more source

Clinical and Biochemical Phenotype Across the Genotypic Spectrum of 21-hydroxylase Deficiency in 457 Individuals.

J Clin Endocrinol Metab
Lao Q, Schulman A, Kulkarni S, Kollender S, Bick D, Moon A, Burkardt D, Merke DP.   +7 more
europepmc   +1 more source

Inverted chimeric RNAi molecules synergistically cotarget MYC and KRAS in KRAS-driven cancers. [PDF]

J Clin Invest
Chareddy YS, Huggins HP, Sahoo SS, Stanland LJ, Gutierrez-Ford C, Whately KM, Edatt L, Azam SH, Fleming MC, Im J, Porrello A, Simmons I, Perry JL, Bowers AA, Egli M, Pecot CV.   +15 more
europepmc   +1 more source

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Recombinant G-CSF-ApoAI Fusion Protein Is a Pleiotropic Factor. [PDF]

Molecules
Miroshnichenko S, Pykhtina M, Mosalev K, Beklemishev A.   +3 more
europepmc   +1 more source

16S rRNA gene amplicon sequences from coastal sediments at the Sonoran Desert and Gulf of California interface. [PDF]

Microbiol Resour Announc
Ramos-Madrigal C, Martínez-Romero E, Tapia-Torres Y, Servín-Garcidueñas LE.   +3 more
europepmc   +1 more source

Insights into the molecular determinants of host specificity in Pseudomonas aeruginosa-infecting phages: a structural and functional analysis of tail fibre proteins. [PDF]

BMC Biol
Zalewska A, Jurczak-Kurek A, Kwiatek M, Myung H, Górniak M.   +4 more
europepmc   +1 more source

RNA-RNA interactome approaches provide in vivo evidence for a critical role of the Hfq rim face in sRNA-mRNA pairing. [PDF]

Nucleic Acids Res
Luo X, Zhang A, Esnault C, De Mets F, Adams PP, Dale RK, Storz G, Gottesman S.   +7 more
europepmc   +1 more source