Results 231 to 240 of about 41,598 (274)

Growth control of genetically modified cells using an antibody/c-Kit chimera

Journal of Bioscience and Bioengineering, 2012
Gene therapy has been regarded as an innovative potential treatment against serious congenital diseases. However, applications of gene therapy remain limited, partly because its clinical success depends on therapeutic gene-transduced cells acquiring a proliferative advantage.
Etsuji, Kaneko, Masahiro, Kawahara, Hiroshi, Ueda, Teruyuki, Nagamune   +3 more
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Chimeras for Genetic Analysis

1994
A chimera—defined as an individual (plant) composed of two or more genotypes— usually results from any heritable change that provides different expression by the descendants of two daughter cells from a mitotic cell division. Chimeras can be very useful in revealing the action of mutant genes in plants.
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Genetic Mosaics and Chimeras in Mammals

1978
Use of Chimeras and Cell Aggregations to Study Developmental Potency, Gene Expression, Control of Phenotype, and Tumor Origin.- Reversion of malignancy and normalized differentiation of teratocarcinoma cells in chimeric mice.- Viable chimeras produced from normal and parthenogenetic mouse embryos.- Ovarian teratomas in mice are derived from oocytes ...
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Segregation of genetic chimeras generated by CRISPR/Cas9 system in rice

Plant Biotechnology Reports, 2018
CRISPR/Cas9 system based on the adaptive immune system of bacteria is an emerging powerful technique of genome editing. Previously, we showed that transgenic rice transformed with a recombinant CRISPR/Cas9-OsJAZ9 binary plasmid display genetic chimerism in T0 generation, and the genetic chimerism includes homozygous and heterogeneous mutation of the ...
Sangyool Lee, Ju-Kon Kim, Yang Do Choi, Geupil Jang   +3 more
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Genetic Mosaics and Chimeras: Implications in Biotechnology

1990
Genetic mosaics are plants which are composed of tissues of two or more genotypes. They should not be confused with plant hybrids, which possess only one genotype; a genotype which is the product of recombination following fertilization. Mosaics can arise spontaneously or can be induced with chemical or physical mutagens.
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Genetic analysis of developmental mechanisms in hydra: VI. cellular composition of chimera hydra

Journal of Cell Science, 1979
ABSTRACT The homeostatic mechanisms that maintain, constant cellular ratios in hydra tissue were studied using mutant and chimeric hydra strains. Mutants having abnormal cellular compositions are isolated through sexual inbreeding of wild hydra, as described in previous papers of this series. Chimeric hydra are produced by
T, Sugiyama, T, Fujisawa
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Growth promotion of genetically modified hematopoietic progenitors using an antibody/c-Mpl chimera

Cytokine, 2011
Thrombopoietin is a potent cytokine that exerts proliferation of hematopoietic stem cells (HSCs) through its cognate receptor, c-Mpl. Therefore, mimicry of c-Mpl signaling by a receptor recognizing an artificial ligand would be attractive to attain specific expansion of genetically modified HSCs. Here we propose a system enabling selective expansion of
Masahiro Kawahara, Jianhong Chen, Takahiro Sogo, Jinying Teng, Makoto Otsu, Masafumi Onodera, Hiromitsu Nakauchi, Hiroshi Ueda, Teruyuki Nagamune   +8 more
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Selective expansion of genetically modified T cells using an antibody/interleukin-2 receptor chimera

Journal of Immunological Methods, 2008
Although adoptive transfer of tumor-specific T cells is a plausible approach for cancer immunotherapy, the therapeutic application was hampered due to severe side effects caused by administration of high-dose interleukin (IL)-2, which was used for long-lasting maintenance of tumor-specific T cells in vivo.
Takahiro Sogo, Masahiro Kawahara, Kouhei Tsumoto, Izumi Kumagai, Hiroshi Ueda, Teruyuki Nagamune   +5 more
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Genetic interaction between the tissues of carnation petals as periclinal chimeras

Radiation Botany, 1974
The Jacqueline and Jacky varietics of carnation with orange red-striped or orange flowers are natural mutants of the red-flowered variety William Sim. Gamma irradiation of their cuttings with 5000 R leads to the formation of a considerable proportion of stems with red flowers and with yellow ones, attesting to their structure as periclinal chimeras. In
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Victorian Chimeras, or, What Literature Can Contribute to Genetics Policy Today

New Literary History, 2007
Through a comparison of H.G. Wells's The Island of Dr. Moreau and Thomas Huxley's writings with recent U.S. policy decisions concerning stem cell research and the creation of chimeras, this article proposes that literary study should play a greater role in genetics policy debates.
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