Results 41 to 50 of about 41,598 (274)

Naturally occurring mutations in envelope mediate virulence of Usutu virus

mBio
Usutu virus (USUV) is a mosquito-transmitted flavivirus that is closely related to West Nile virus. Recently, USUV emerged in Europe, where it has caused multiple bird die-off events and neuroinvasive disease in humans.
Megan B. Vogt, Jeffrey M. Marano, William J. Hanrahan, Seth A. Hawks, Anne M. Brown, Sheryl Coutermarsh-Ott, James Weger-Lucarelli, Nisha K. Duggal   +7 more
doaj   +1 more source

Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones [PDF]

, 2016
Our previous paper (Wilkinson et al, 2016) used high-resolution cryo-electron microscopy to solve the structure of the Escherichia coli RecBCD complex, which acts in both the repair of double-stranded DNA breaks and the degradation of bacteriophage DNA ...
Aedo, Afonine, Amundsen, Amundsen, Bannister, Baños-Sanz, Cano, Cirz, CLSI, Cole, Court, Court, Cronan, Darrigo, Datta, Dillingham, Emsley, Forage, González-Soltero, Henderson, Kennaway, Kulkarni, Li, Liu, Liu, López, McDaniel, Murphy, Murphy, Murphy, Muyrers, Paczosa, Pettersen, Robinson, Sakaki, Scheres, Singleton, Tamae, Urnavicius, Wang, Wiegand, Wigley, Wilkinson, Zhang, Zhang   +44 more
core   +5 more sources

Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Three-dimensional modeling of single stranded DNA hairpins for aptamer-based biosensors. [PDF]

, 2017
Aptamers consist of short oligonucleotides that bind specific targets. They provide advantages over antibodies, including robustness, low cost, and reusability.
Jeddi, Iman, Saiz, Leonor
core   +2 more sources

Chimera state in a two-dimensional network of coupled genetic oscillators

EPL (Europhysics Letters), 2019
Due to the interaction of the cells, cellular communications are carried out with emergent collective behaviors, such as synchronization. In this paper, a network of coupled genetic oscillators is studied by considering a two-dimensional framework and diffusive coupling.
Liu, Yongjian, Khalaf, Abdul Jalil M., Jafari, Sajad, Hussain, Iqtadar   +3 more
openaire   +3 more sources

Genetic chimeras reveal the autonomy requirements for Vsx2 in embryonic retinal progenitor cells [PDF]

Neural Development, 2015
Vertebrate retinal development is a complex process, requiring the specification and maintenance of retinal identity, proliferative expansion of retinal progenitor cells (RPCs), and their differentiation into retinal neurons and glia. The homeobox gene Vsx2 is expressed in RPCs and required for the proper execution of this retinal program. However, our
Sigulinsky, Crystal L, German, Massiell L, Leung, Amanda M, Clark, Anna M, Yun, Sanghee, Levine, Edward M   +5 more
openaire   +2 more sources

Rheumatologic Manifestations of Patients With Type B Insulin Resistance

Arthritis Care &Research, EarlyView.
Objective The objectives of this study were to identify laboratory and clinical features associated with type B insulin resistance (TBIR), a rare condition caused by autoantibodies that inhibit the insulin receptor, most frequently occurring in the setting of systemic lupus erythematosus (SLE), and to increase awareness of this rare, life‐threatening ...
S. Amara Ogbonnaya, Sandra G. Williams, Raphael A. Kirou, Marissa Lightbourne, Rebecca J. Brown   +4 more
wiley   +1 more source

Acta Societatis Botanicorum Poloniae – One Hundred Years of Evolution in Form and Content (1923–2022)

Studia Historiae Scientiarum
Acta Societatis Botanicorum Poloniae (ASBP) is the oldest journal of the Polish Botanical Society, published since 1923. Over the past 100 years, it has played an important role in the development of botany in Poland.
Piotr Köhler
doaj   +1 more source

Regulation of Synaptic Pumilio Function by an Aggregation-Prone Domain [PDF]

, 2010
We identified Pumilio (Pum), a Drosophila translational repressor, in a computational search for metazoan proteins whose activities might be regulated by assembly into ordered aggregates.
Menon, Kaushiki P., Salazar, Anna M., Silverman, Edward J., Zinn, Kai   +3 more
core   +2 more sources