Results 171 to 180 of about 2,052,688 (283)

Calcineurin Inhibitor-Free, mTOR-Based Immunosuppression in Chimeric Antigen Receptor T-Cell Therapy for Post-Transplant Lymphoproliferative Disorder. [PDF]

EJHaem
Mappoura M, Hajj Younes Y, Wang S, Baldet K, De Ramon Ortiz C, Morin S, Marouridi-Levrat S, Pradier A, Melotti A, Purwar P, Bernardi C, Ho L, Egervari K, Ducreux J, Longval T, Bertoni F, Chalandon Y, Haidar F, de Seigneux S, Villard J, Olivier V, Simonetta F.   +21 more
europepmc   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Chimeric antigen receptor T cell therapy in autoimmune neurological disease: current status of efficacy and safety. [PDF]

BMJ Neurol Open
Bradhurst P, Hardy TA, Riminton S.
europepmc   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

NOT-gated chimeric antigen receptor circuits in T and NK cells. [PDF]

Cell Syst
Lee S, Chen J, Siddiqui MY, Choi J, Huang J, Lee D, Lee CT, Almudhfar N, Tian M, Banicki A, Ayala MG, Gordley R, Lu TK, Frankel NW, Wong WW.   +14 more
europepmc   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Cord Blood-Derived Fibroblast Activation Protein-Targeted Chimeric Antigen Receptor Natural Killer Cells Persist in Vivo. [PDF]

Cancer Sci
Hiroshima T, Kimura T, Maekawa M, Noguchi M, Matsui T, Ikeda S, Suga M, Nagata H, Kimura K, Fukui E, Kanou T, Ose N, Morii E, Shintani Y, Hosen N.   +14 more
europepmc   +1 more source

Aptamer–Based Targeted Protein Degradation: Mechanistic Principles, Delivery Strategies, and Translational Opportunities

Medicinal Research Reviews, EarlyView.
ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik, Suyeon Son, Jaesung Lee, Ki Soo Park   +3 more
wiley   +1 more source

Chimeric antigen receptor-engineered cell therapy for asthma: advances in targeting type 2 inflammation and translational challenges. [PDF]

Front Immunol
Niu Y, Jian C, Liu P, Wu M, Li H, Li X, Zhi L.   +6 more
europepmc   +1 more source

SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting

Medicinal Research Reviews, EarlyView.
ABSTRACT SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA repair, angiogenesis ...
Maryam Jama, Michael Overduin, Khaled H. Barakat   +2 more
wiley   +1 more source