Results 161 to 170 of about 2,052,688 (283)

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Armored Chimeric Antigen Receptor T-cell Therapy Targets Antigen-Heterogeneous Glioma. [PDF]

Cancer Res
Clubb JD, Shih RM, Gao TA, Shafer A, Vajragiri S, Lam K, Talluri S, Bouren A, Brown CE, Ruivo P, Prins RM, Wu HC, Chen YY.   +12 more
europepmc   +1 more source

Chimeric antigen receptor T cells (CAR-T) as a cancer treatment

Tämä tutkielma käsittelee kimeeristä antigeenireseptoria kantavien T-solujen (chimeric antigen receptor T cells, CAR-T) käyttöä syövän hoidossa. Tutkielmassa käsitellään kimeerisen antigeenireseptorin rakennetta, toimintaa ja valmistusta sekä esitellään ...
Rinta-Jaskari, Ellen
core  

Temporal Improvement in Post‐Relapse Survival Among Children With Relapsed B‐Cell Acute Lymphoblastic Leukemia in China: A Multicenter Retrospective Cohort Study, 2015–2023

iNew Medicine, EarlyView.
ABSTRACT Objective Whether post‐relapse survival in pediatric B‐cell acute lymphoblastic leukemia (B‐ALL) has improved in contemporary Chinese practice remains unclear. We evaluated temporal changes in survival and salvage treatment patterns among children with relapsed B‐ALL treated during 2015–2023. Methods This multicenter retrospective cohort study
Jinhua Chu, Chengzhu Liu, Bohan Li, Wenyu Yang, Yanjing Tang, Weina Zhang, Aijun Zhang, Aiguo Liu, Yongjun Fang, Frankie W. T. Cheng, Jiashi Zhu, Yining Qiu, Ningling Wang, Shaoyan Hu   +13 more
wiley   +1 more source

Editorial: Chimeric antigen receptor T cell therapies and bispecific antibodies in hematologic malignancies. [PDF]

Front Oncol
Zhu Y.
europepmc   +1 more source

Geriatric Regenerative Medicine: Mechanisms, Strategies, and Clinical Translation

iNew Medicine, EarlyView.
The pathological drivers of aging—stem cell exhaustion, cellular senescence with SASP, and aged extracellular matrix—are precisely targeted by three corresponding mechanism‐based strategies: stem cell therapies (rejuvenation, regeneration, and replacement), senolytic/senomorphic agents (D + Q, fisetin, vaccines, and CAR‐T), and senescence‐targeting ...
Qiang Li, Chaoyang Wang, Junci Chong, Zishu Liu, Boying Wang, Shiyu Liu, Xingcai Zhang, Hengrui Liu, Shuanglin Qin, ChuTse Wu, Beidong Chen, Zhigang Chang   +11 more
wiley   +1 more source

Chimeric antigen receptor T cell therapy cardiotoxicity: a narrative review. [PDF]

Cardiooncology
Sinigiani G, Scapinello G, Berno T, Piazza F, Cipriani A.   +4 more
europepmc   +1 more source

The Regulatory Role and Mechanism of Myoferlin in Mitophagy During Papillary Thyroid Carcinogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Papillary thyroid carcinoma (PTC) is the most prevalent subtype of thyroid cancer; however, the regulatory mechanisms by which mitophagy influences its progression remain inadequately elucidated. This study sought to examine the role of myoferlin (MYOF) in mitophagy and its molecular basis during PTC development. Utilizing three paired PTC and
Wen‐Chao Lyu, Yang‐Shuai Wang, Chun‐Yang Shang, Ming Qi, Tong‐Chang Li, Li‐Xin Lian, Hai‐Quan Qiao   +6 more
wiley   +1 more source

Chimeric antigen receptor T-cell therapy and cardiovascular outcomes in US Medicare beneficiaries. [PDF]

Eur Heart J
Zaghlol R, Deych E, Ladin DA, Russler-Germain DA, Schiffer W, Baral N, Waken RJ, Ky B, Joynt Maddox KE, Mitchell JD.   +9 more
europepmc   +1 more source

Ion Activation Methods for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Mass spectrometry (MS) has emerged as a premier method used to characterize the sequences of proteins. Top‐down proteomics aims to capture the multiple sources of structural diversity reflected in proteins, such as those that arise from alternative RNA splicing events or the addition of post‐translational modifications. Tandem MS (i.e., MS/MS)
Jada N. Walker, Jennifer S. Brodbelt
wiley   +1 more source