Results 241 to 250 of about 181,087 (306)

Revolution in Cell Therapy: In Vivo Chimeric-Antigen-Receptor-T-Cell Therapy Breakthroughs and Promises for the Future. [PDF]

Research (Wash D C)
Lai M, Shao W, Mao J, Ye Q.
europepmc   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Immune Effector Cell-Associated Neurotoxicity Delayed Relapse After Chimeric Antigen Receptor T-Cell Therapy: A Case Report. [PDF]

Neurol Neuroimmunol Neuroinflamm
Favero A, Mohamed S, Battista ML, Cenacchi V, Sartori A, Mazzon G, Bratina A, Tomaselli M, Patriarca F, Zaja F, Manganotti P, Benussi A.   +11 more
europepmc   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Cost-Effectiveness of Chimeric Antigen Receptor (CAR) T-Cell Therapy for Blood Cancers: An Updated Systematic Review. [PDF]

Pharmacoecon Open
Patel N, Farid S, Gomes M.
europepmc   +1 more source

Precision mRNA Delivery via Ultrasound‐Controlled Release Perfluorocarbon Emulsions: An Innovative Ultrasound Theranostic Strategy with 19F MRI Feasibility

Small, EarlyView.
A key challenge in advancing messenger RNA (mRNA) therapeutics in cardiovascular diseases lies in achieving controlled release at the precise site within the vasculature. This study presents the development of perfluorocarbon nanodroplets with exceptional theranostic potential, enabling real‐time tracking through ultrasound and fluorine‐19 (19F ...
Haikun Liu, Mark Louis P. Vidallon, Yuyang Song, Aidan P. G. Walsh, Henry Gordon, Shulei Ren, Pengkai Shi, Bangyan Xu, Mitchell J. Moon, Sylvain Trépout, Rico F. Tabor, Alexis I. Bishop, Ulrich Flögel, Karlheinz Peter, Xiaowei Wang   +14 more
wiley   +1 more source

Bicistronic-CD19/22 Chimeric Antigen Receptor T-Cell Therapy for Childhood Refractory Lupus Nephritis. [PDF]

Kidney Int Rep
Mao Y, Shen W, Shen J, Zhang C, An K, Tang Y, Qian J, Li B, Yin L.   +8 more
europepmc   +1 more source

Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment for Solid Tumors

Small Science, EarlyView.
This review highlights recent advances in nanomedicine that enhance chimeric antigen receptor (CAR) T cell therapy against solid tumors. It discusses key barriers to CAR T cell efficacy and outlines nanotechnology‐based strategies to improve tumor targeting, remodel the immunosuppressive microenvironment, and integrate nanomaterials into CAR T cell ...
Stephen O’Rourke, Nuo Xu, Hongjun Wang, Hexin Chen   +3 more
wiley   +1 more source

Two-stage inertial microfluidics enrichment of activated T-cells towards a bead-less chimeric antigen receptor manufacturing protocol. [PDF]

Med Oncol
Elsemary MT, Maritz MF, Smith LE, Warkiani ME, Thierry B.   +4 more
europepmc   +1 more source

Cardenolide‐Engineered Extracellular Vesicles Augment Drug Uptake and Cytotoxicity in Non‐small Cell Lung Cancer Cells

Small Methods, EarlyView.
Cardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Maja Dorfner, Anika Mifka, Rodrigo Maia de Pádua, Izabella Thaís da Silva, Iara Zanella Guterres, Lorenzo Sana, Gregor Fuhrmann, Jennifer Munkert   +7 more
wiley   +1 more source