Results 241 to 250 of about 181,578 (308)

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders. [PDF]

MedComm (2020)
Fan Z, Zhang L, Yu H.
europepmc   +1 more source

bacNeo: A Computational Toolkit for Identifying Bacteria‐Derived Neoantigens in Human Cancers

iMetaMed, EarlyView.
We present bacterial neoantigen (bacNeo), a multi‐omics‐based computational software to classify bacterial components (BACC), type bacteria‐bound HLA alleles (BACH), and prioritize bacterial peptides as neoantigens (BACP). Bacterial neoantigen potential is quantified by score for peptide antigenicity recognition & kinetics (SPARK), enabling ...
Yunzhe Wang, Li Yuan, Katie W. Gu, Xiangdong Cheng, Bo Wen, Zhao Zhang   +5 more
wiley   +1 more source

Cost-Effectiveness of Maintaining Higher Stem-Cell Collection Thresholds in the Chimeric Antigen Receptor T-Cell Era for Multiple Myeloma. [PDF]

JCO Clin Cancer Inform
Malek E, Betts B, Herr M, Davila M, Holtan S, Driscoll JJ, Yu H.   +6 more
europepmc   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Why Pediatric CAR‐T Therapies Still Lag Behind: Insights from Six Treatments Centrally Approved in Europe

Clinical Pharmacology &Therapeutics, EarlyView.
Lisa Hanquet, Jean‐Michel Dogné, Flora T. Musuamba   +2 more
wiley   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Patients' and caregivers' perspectives on preparedness for and experience with chimeric antigen receptor T-cell therapy. [PDF]

Oncologist
Barata A, Coffey B, Amonoo HL, Traeger L, Nelson AM, Johnson PC, Dhwale TM, Karpinski K, Jim HSL, El-Jawahri A.   +9 more
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Operationalizing Access for Chimeric Antigen Receptor T cell Therapies: A Cross-functional Perspective. [PDF]

Mayo Clin Proc Innov Qual Outcomes
Singh S, Greulich C, Perez A, Terrell K, Walz-Jensen J, Dalzell MD.   +5 more
europepmc   +1 more source

CXCR3 enhanced murine chimeric antigen receptor T cells in the treatment of solid tumors. [PDF]

Transl Cancer Res
Zhang X, Zhu L, Wang Q, Xu Q, Wang X, Yu F.   +5 more
europepmc   +1 more source