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Unlocking the potential of Tregs: innovations in CAR technology
Frontiers in Molecular Biosciences, 2023 Regulatory T cells (Tregs) adoptive immunotherapy is emerging as a viable treatment option for both autoimmune and alloimmune diseases. However, numerous challenges remain, including limitations related to cell number, availability of target-specific ...
Christopher J. Requejo Cier +2 more
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The Other Face of Chimeric Antigen Receptors [PDF]
Molecular Therapy, 2014 The concept of chimeric antigen receptor (CAR) was pioneered in 1989 by Eshhar and colleagues with the specific goal of providing an alternative means by which T lymphocytes can engage antigens expressed by target cells.1 Until recently, the focus of CAR–T cell research has been on achieving effector function in T lymphocytes that can target cancer ...
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Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells
Frontiers in Genetics, 2020 The term cancer stem cell (CSC) starts 25 years ago with the evidence that CSC is a subpopulation of tumor cells that have renewal ability and can differentiate into several distinct linages.
Rowa Y. Alhabbab
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Drug functional remapping: a new promise for tumor immunotherapy
Frontiers in OncologyThe research and development of new anti-cancer drugs face challenges such as high costs, lengthy development cycles, and limited data on side effects.
Jiayi Dong +27 more
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The promise and potential pitfalls of chimeric antigen receptors [PDF]
Current Opinion in Immunology, 2009 One important purpose of T cell engineering is to generate tumor-targeted T cells through the genetic transfer of antigen-specific receptors, which consist of either physiological, MHC-restricted T cell receptors (TCRs) or non MHC-restricted chimeric antigen receptors (CARs). CARs combine antigen-specificity and T cell activating properties in a single
Sadelain, Michel +2 more
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Experimental Biology and MedicineNatural killer (NK) cells represent a fundamental component of the innate immune system, endowed with the ability to identify and eradicate virus-infected and malignant cells.
Yu Xiang +18 more
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Chimeric Antigen Receptors Targeting Human Cytomegalovirus [PDF]
The Journal of Infectious Diseases, 2020 Abstract Human cytomegalovirus (CMV) is a ubiquitous pathogen that causes significant morbidity in some vulnerable populations. Individualized adoptive transfer of ex vivo expanded CMV-specific CD8+ T cells has provided proof-of-concept that immunotherapy can be highly effective, but a chimeric antigen receptor (CAR) approach would ...
Ali, Ayub +9 more
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In-depth analysis of the safety of CAR-T cell therapy for solid tumors
Frontiers in ImmunologyIn recent years, the rapid progress in oncology, immunology, and molecular biology has dramatically advanced cancer immunotherapy, particularly CAR-T cell therapy.
Jiayi Dong +33 more
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Natural killer cell immunotherapy in glioblastoma
Discover Oncology, 2022 Glioblastoma (GBM) is one of the most difficult cancers to treat because GBM has the high therapeutic resistance. Recently, immunotherapies for GBM have been used instead of conventional treatments.
Hamed Hosseinalizadeh +5 more
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Carcinoembryonic Antigen Gene Family [PDF]
, 1991 The carcinoembryonic antigen (CEA) gene family belongs to the immunoglobulin supergene family and can be divided into two main subgroups based on sequence comparisons.
Zimmermann, Wolfgang +2 more
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