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Frontiers in Immunology, 2022 Co-stimulation is critical to the function of chimeric antigen receptor (CAR) T-cells. Previously, we demonstrated that dual co-stimulation can be effectively harnessed by a parallel (p)CAR architecture in which a CD28-containing second generation CAR is
Leena Halim +13 more
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CAR-T cell therapy for hematological malignancies: History, status and promise
Heliyon, 2023 For many years, the methods of cancer treatment are usually surgery, chemotherapy and radiation therapy. Although these methods help to improve the condition, most tumors still have a poor prognosis.
Chao Wang +3 more
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Unlocking the potential of Tregs: innovations in CAR technology
Frontiers in Molecular Biosciences, 2023 Regulatory T cells (Tregs) adoptive immunotherapy is emerging as a viable treatment option for both autoimmune and alloimmune diseases. However, numerous challenges remain, including limitations related to cell number, availability of target-specific ...
Christopher J. Requejo Cier +2 more
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Research Progress of Multi-target CAR-T Cell Therapy for Cancer
Zhongliu Fangzhi Yanjiu, 2022 Chimeric antigen receptor T cell (CAR-T) is a kind of adoptive cell immunotherapy, in which T cells are genetically modified to exert targeted killing effect on tumors.
JIANG Yao +5 more
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An Interesting Similarity of Bacillus Calmette-Guerin and Chimeric Antigen Receptor T Cells
Translational Research in Urology, 2020 Intravesical Bacillus Calmette-Guerin (BCG) is approved for non-muscle invasive bladder cancer treatment a long time ago. Chimeric antigen receptor T cells (CAR-Tcell), are T cells are genetically engineered T cells that produce an artificial T-cell ...
Seyed Saeed Tamehri Zadeh +1 more
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Chimeric Antigen Receptors Expand the Repertoire of Antigenic Macromolecules for Cellular Immunity
Cells, 2021 T-cell therapies have made significant improvements in cancer treatment over the last decade. One cellular therapy utilizing T-cells involves the use of a chimeric MHC-independent antigen-recognition receptor, typically referred to as a chimeric antigen ...
John T. Keane, Avery D. Posey
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Advances in Cancer Biology - Metastasis, 2022 Cancer is the leading cause of death globally after cardiovascular diseases. Conventional therapeutic strategies have had minimal success rate. Recently, immunotherapy, particularly chimeric antigen receptor T cells (CAR T cells), has emerged as the most
Ubaid Ahmad +9 more
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The Application of Nanobody in CAR-T Therapy
Biomolecules, 2021 Chimeric antigen receptor (CAR) T therapy represents a form of immune cellular therapy with clinical efficacy and a specific target. A typical chimeric antigen receptor (CAR) construct consists of an antigen binding domain, a transmembrane domain, and a ...
Chaolemeng Bao +9 more
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Ligand-based CAR-T cell: Different strategies to drive T cells in future new treatments
Frontiers in Immunology, 2022 Chimeric antigen receptor (CAR)-based therapies are presented as innovative treatments for multiple malignancies. Despite their clinical success, there is scientific evidence of the limitations of these therapies mainly due to immunogenicity issues ...
Alejandro Ramírez-Chacón +13 more
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Preclinical and clinical studies of CAR-NK-cell therapies for malignancies
Frontiers in Immunology, 2022 The development of chimeric antigen receptor T (CAR-T) cell therapy, a specific type of immunotherapy, in recent decades was a fantastic breakthrough for the treatment of hematological malignancies. However, difficulties in collecting normal T cells from
Hongwen Li +12 more
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