Results 51 to 60 of about 70,663 (209)
Chimeric Antigen Receptor T-Cell Revolution Remodeling Immunity to Conquer Autoimmune Disease
ResearchChimeric antigen receptor T (CAR-T) cell therapy, a groundbreaking technology in tumor immunotherapy, has demonstrated unprecedented potential in the field of autoimmune diseases in recent years.
Wenxia Shao +3 more
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Regions of the T cell receptor alpha and beta chains that are responsible for interactions with CD3. [PDF]
, 1991 The T cell antigen receptor consists of the Ti alpha/beta heterodimer which recognizes antigen, and the associated CD3 chains, thought to be involved in signal transduction.
Tan, L, Turner, J, Weiss, A
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Chimeric antigen receptors: “CARs” in the fast lane for rheumatology
Current Opinion in RheumatologyPurpose of review Recent advances in hematology-oncology have pioneered cell-mediated elimination of pathologic B-cell populations employing chimeric antigen receptor (CAR) T cells. In this review, we discuss recent adoption of CAR-T treatment for severe refractory autoimmune disease.
Johnson, Nathan M., Koumpouras, Fotios
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Recent advances in adoptive cell therapy for cancer immunotherapy
Frontiers in ImmunologyAdoptive cell therapy (ACT), a key direction in tumor immunotherapy, has achieved remarkable progress in recent years. This paper systematically reviews the current status and future trends of ACT, covering lymphokine-activated killer cells (LAK), tumor ...
Jiameng Qian +3 more
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Nature Communications, 2020 One cause of relapse in cancer patients treated with chimeric antigen receptor (CAR) T cells is the loss of CAR-targeted antigens, which is particularly common in multiple myeloma (MM). Here the authors engineer a CAR recognizing two common MM-associated
Eugenia Zah +8 more
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Development of Chimeric Antigen Receptor (CAR) T Processes
Biology of Blood and Marrow Transplantation, 2019 Topic Significance & Study Purpose/Background/Rationale Chimeric antigen receptor therapy (CAR-T) is an autologous genetically engineered cell that can lead to dramatic responses in patients with refractory or relapsed leukemia and lymphoma.
Theresa M. Latchford, D. Kathryn Tierney
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Special Chimeric Antigen Receptor (CAR) Modifications of T Cells: A Review
Frontiers in Oncology, 2022 Chimeric antigen receptor (CAR) -T cell therapy has become one of the hot topics in tumor immunity research in recent years. Although CAR-T cell therapy is highly effective in treating hematological malignancies, there are numerous obstacles that prevent CAR-T cells from having anti-tumor effects.
Lele Miao +14 more
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Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response
Nature Communications, 2019 Supraphysiological T cell activation by chimeric antigen receptor (CAR) contributes to T cell exhaustion and adverse events in CAR T cell therapies. Here the authors engineer a synthetic antigen receptor that integrates into the endogenous TCR complex ...
Patrick A. Baeuerle +20 more
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Oncologic Emergencies: Immune-Based Cancer Therapies and Complications [PDF]
, 2020 Cancer therapies have undergone several recent advancements. Current cancer treatments include immune-based therapies comprised of checkpoint inhibitors, and adoptive immunotherapy; each treatment has the potential for complications that differ from ...
Brém, Elizabeth +2 more
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The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]
, 2019 Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua +4 more
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