Results 81 to 90 of about 311,648 (345)

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Preparation of hexagonal GeO2 particles with particle size and crystallinity controlled by peptides, silk and silk-peptide chimeras [PDF]

, 2014
We demonstrate the use of silk based proteins to control the particle/crystallite size during GeO2 formation, using a bio-mimetic approach at circumneutral pH and ambient temperature. Multicrystalline GeO2 was prepared from germanium tetraethoxide (TEOG)
Avanzato, Belton, Brown, Brunner, Canabady-Rochelle, Carole C. Perry, Chiu, Cohen-Karni, Coradin, Davis, Devyatykh, Dickerson, Dickerson, Dickerson, Ellwood, Estefania Boix, Feng, Fleming, Foo, Gosline, Gulrajani, Inoue, Kanno, Kawai, Kim, Kim, Kim, Lawrence, Lippincott, Micoulaut, Mieszawska, Mieszawska, Murphy, Parker, Patwardhan, Perez-Rigueiro, Puddu, Puddu, Scherrer, Sewell, Slocik, Smith, Sofia, Valeria Puddu, Wu, Wu, Young, Zhou   +47 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Active immunization with norovirus P particle-based amyloid-β chimeric protein vaccine induces high titers of anti-Aβ antibodies in mice

BMC Immunology, 2019
Background Active immunotherapy targeting amyloid-β (Aβ) is a promising treatment for Alzheimer’s disease (AD). Numerous preclinical studies and clinical trials demonstrated that a safe and effective AD vaccine should induce high titers of anti-Aβ ...
Ping Yang, Yongqing Guo, Yao Sun, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu, Wei Kong   +8 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Protective Efficacy of the OprF/OprI/PcrV Recombinant Chimeric Protein Against Pseudomonas aeruginosa in the Burned BALB/c Mouse Model

Infection and Drug Resistance, 2020
Mohammad Hadi Fakoor,1 Seyed Latif Mousavi Gargari,2 Parviz Owlia,3 Azar Sabokbar1 1Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran; 2Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, Iran ...
Fakoor MH, Mousavi Gargari SL, Owlia P, Sabokbar A   +3 more
doaj  

Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs

Pharmaceuticals, 2020
New therapeutic modalities are needed to address the problem of pathological but undruggable proteins. One possible approach is the induction of protein degradation by chimeric drugs composed of a ubiquitin ligase (E3) ligand coupled to a ligand for the ...
Minoru Ishikawa, Shusuke Tomoshige, Yosuke Demizu, Mikihiko Naito   +3 more
doaj   +1 more source

Evaluation of naturally acquired IgG antibodies to a chimeric and non-chimeric recombinant species of Plasmodium vivax reticulocyte binding protein-1: lack of association with HLA-DRB1*/DQB1* in malaria exposed individuals from the Brazilian Amazon. [PDF]

PLoS ONE, 2014
The development of modular constructs that include antigenic regions targeted by protective immune responses is an attractive approach for subunit vaccine development.
Amanda Ribeiro Ferreira, Balwan Singh, Monica Cabrera-Mora, Alana Cristina Magri De Souza, Maria Teresa Queiroz Marques, Luis Cristovão Sobrino Porto, Fatima Santos, Dalma Maria Banic, J Mauricio Calvo-Calle, Joseli Oliveira-Ferreira, Alberto Moreno, Josué Da Costa Lima-Junior   +11 more
doaj   +1 more source

Understanding the process of envelope glycoprotein incorporation into virions in simian and feline immunodeficiency viruses [PDF]

, 2014
The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis.
Affranchino, Jose Luis, Gonzalez, Silvia Adriana   +1 more
core   +4 more sources