Results 91 to 100 of about 38,150 (242)

Polyclonal Recipient nTregs Are Superior to Donor or Third-Party Tregs in the Induction of Transplantation Tolerance

Journal of Immunology Research, 2015
Induction of donor-specific tolerance is still considered as the “Holy Grail” in transplantation medicine. The mixed chimerism approach is virtually the only tolerance approach that was successfully translated into the clinical setting.
Nina Pilat, Christoph Klaus, Karin Hock, Ulrike Baranyi, Lukas Unger, Benedikt Mahr, Andreas M. Farkas, Fritz Wrba, Thomas Wekerle   +8 more
doaj   +1 more source

A single JAK2‐V617F hematopoietic stem cell can initiate myeloproliferative neoplasm when transplanted into non‐conditioned recipient mice

HemaSphere, Volume 10, Issue 5, May 2026.
Abstract Myeloproliferative neoplasms (MPNs) are clonal disorders of hematopoietic stem cells (HSCs) that are most frequently caused by acquired somatic mutations in JAK2. A number of conditional mouse models of JAK2‐V617F‐driven MPN have been generated that rely on Cre‐LoxP‐mediated activation, resulting in polyclonal disease.
Quentin Kimmerlin, Morgane Hilpert, Nils Hansen, Alexandre Guy, Marc Usart, Jan Stetka, Patryk Sobieralski, Tiago Almeida Fonseca, Hui Hao‐Shen, Radek C. Skoda   +9 more
wiley   +1 more source

Haploid Mutation Mapping Identifies a Homoeologous Non‐Reciprocal Translocation Linked to Reduced Fibre and Enhanced Protein in Brassica napus

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3219-3243, May 2026.
ABSTRACT A key challenge for the genetic improvement of canola (Brassica napus), one of the world's most important oilseeds, is the limited natural variation for commercially important traits. The creation of new variation is hindered by the lack of functional knowledge about genes controlling these traits.
Morgan W. Kirzinger, Sarika Saini, Andrea T. Todd, Ushan Alahakoon, Kevin C. Koh, Justin B. Nichol, HaiYing Yuan, Kevin Fengler, Victor Llaca, Dustin Cram, Sampath Perumal, Wali Soomro, Magda Konopka, Tancey Melchkart, Venkat Bandi, Yasmina Bekkaoui, Yifang Tan, Chad Matsalla, Andrew G. Sharpe, Carl Gutwin, Fred Thoonen, Igor Falak, Chad Koscielny, Stuart Gardner, Isobel A. P. Parkin, Marcus A. Samuel, Alison M. R. Ferrie, Dave Charne, Daoquan Xiang, Jetty S. S. AmmiRaju, Sateesh Kagale   +30 more
wiley   +1 more source

Advances in detection techniques for congenital blood group chimerism

Zhongguo shuxue zazhi
Congenital blood group chimerism refers to the coexistence of two or more distinct blood types within an individual, resulting from the presence of hematopoietic cell populations with different genotypes. Consequently, red blood cells in such individuals
ZHANG Shuo, YANG Hongyan, GAO Yuhan, QIN Ranran, WANG Xinrui, ZHANG Ke, LI Yifan, HOU Ruiqin   +7 more
doaj   +1 more source

Generation of insulin-like growth factor 1 receptor-knockout pigs as a potential system for interspecies organogenesis

Regenerative Therapy
Background: To overcome organ shortage during transplantation, interspecies organ generation via blastocyst complementation has been proposed, although not yet in evolutionarily distant species.
Masaki Nagaya, Ayuko Uchikura, Kazuaki Nakano, Masahito Watanabe, Hitomi Matsunari, Kazuhiro Umeyama, Naoaki Mizuno, Toshiya Nishimura, Hiromitsu Nakauchi, Hiroshi Nagashima   +9 more
doaj   +1 more source

A prenatal case misunderstood as specimen confusion: 46,XY/46,XY chimerism

BMC Pregnancy and Childbirth
Chimerism results from the fusion of two zygotes in a single embryo, whereas mosaicism results from mitotic errors in a single zygote. True human chimerism is rare, with fewer than 100 cases reported in the literature. Here, we report a case in which the
Lin Chen, Li Wang, Yang Zeng, Daishu Yin, Feng Tang, Dan Xie, Hongmei Zhu, Lingping Li, Jing Wang   +8 more
doaj   +1 more source

Characterization of mixed allogeneic chimeras. Immunocompetence, in vitro reactivity, and genetic specificity of tolerance. [PDF]

, 1985
Mixed allogeneically reconstituted mice (B10 + B10.D2----B10) that specifically accept B10.D2 tail skin allografts were examined for in vivo and in vitro immunocompetence, patterns of hematopoietic repopulation, and in vitro reactivity.
Barbieri, SA, Bluestone, JA, Ildstad, ST, Sachs, DH, Wren, SM   +4 more
core  

Three years of follow-up bone marrow-augmented organ transplant recipients: The impact on donor-specific immune modulation [PDF]

, 1997
Banas, R, Bentlejewski, C, Corry, R, Dodson, F, Egidi, F, Fontes, P, Fung, JJ, Griffith, B, Iyengar, A, Jordan, M, Keenan, R, Pavlick, M, Pham, S, Rao, AS, Shapiro, R, Spichty, K, Starzl, TE, Zeevi, A   +17 more
core   +1 more source

Bone marrow augmentation in renal transplant recipients [PDF]

, 1998
Aitouche, Barber, Billingham, Demetris, Fontes, Garcia-Morales, Ildstad, Iyengar, McDaniel, Monaco, Monaco, Monaco, Monaco, Monaco, Najarian, Quesenberry, R Shapiro, Rao, Rao, Rao, Rao, Ricordi, Shapiro, Shapiro, Slavin, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Strober, T.E Starzl, Thomas, Thomas, Wood, Wood, Zinkernagel, Zinkernagel, Zinkernagel   +39 more
core   +1 more source

Effects of peritransplant administration of hematopoietic growth factors on the development of chronic allograft rejection [PDF]

, 1999
A.J Demetris, Demetris, M Terakura, Murase, N Ichikawa, N Murase, Q Ye, Starzl, T Sakamoto, T.E Starzl, Tashiro, Z Liu   +11 more
core   +1 more source