Results 51 to 60 of about 1,289,528 (197)

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu   +4 more
wiley   +1 more source

Trump Tariffs 2.0: Assessing the Impacts on US Distilled Spirits Imports

open access: yesAgribusiness, EarlyView.
ABSTRACT The proposed 25% tariff on Mexico and Canada could have significant repercussions on US imports of distilled spirits. This study estimates US import demand across various spirit categories (e.g., tequila, whiskey) and assesses the potential impact of the proposed tariff.
Andrew Muhammad
wiley   +1 more source

Not All Agreements Are Equal: Heterogeneous Effects of RTAs on Latin American Agri‐Food Exports, 1990–2019

open access: yesAgribusiness, EarlyView.
ABSTRACT Since the final decade of the 20th century, Latin American countries have increasingly regarded the signing of regional trade agreements (RTAs) as a promising strategy for expanding their exports. Within this context, the main objective of this study is to assess the impact of RTAs on agri‐food exports in Latin America over the period 1990 ...
María‐Isabel Ayuda   +2 more
wiley   +1 more source

[News Clip: Alligator Killed]

open access: yes, 1959
Video footage from the WBAP-TV television station in Fort Worth, Texas, to accompany a news story about an alligator that was killed by J.W.
WBAP-TV (Television station : Fort Worth, Tex.)
core   +1 more source

Discovery of the elusive leptin in birds: identification of several 'missing links' in the evolution of leptin and its receptor. [PDF]

open access: yesPLoS ONE, 2014
Leptin is a pleiotropic protein best known for regulation of appetite and fat storage in mammals. While many leptin orthologs have been identified among vertebrates, an authentic leptin in birds has remained elusive and controversial.
Jeremy W Prokop   +10 more
doaj   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

open access: yesAdvanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta   +3 more
wiley   +1 more source

AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective

open access: yesAdvanced Intelligent Discovery, EarlyView.
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley   +1 more source

Using local ecological knowledge to identify land-use threats to the last wild population of the Chinese alligator Alligator sinensis

open access: yesOryx
Conservation management in human-modified landscapes requires information on the sustainability of interactions between people and biodiversity. Wild Chinese alligators Alligator sinensis only persist within the National Chinese Alligator Reserve in ...
Erika Y. X. Lau   +5 more
doaj   +1 more source

Crystal Structure Prediction of Inorganic Materials: A Benchmark and Modern Evaluation

open access: yesAdvanced Intelligent Discovery, EarlyView.
Predicting a crystal’s structure from composition alone is a long‐standing challenge in materials discovery. The CSP180 benchmark of 180 inorganic crystals evaluates thirteen crystal structure prediction algorithms requiring no density functional theory (DFT) against DFT‐based baselines across twelve metrics.
Lai Wei   +9 more
wiley   +1 more source

[News Clip: Alligator]

open access: yes, 1958
Video footage from the WBAP-TV station in Fort Worth, Texas to accompany a news story about an alligator at the Dallas animal ...
WBAP-TV (Television station : Fort Worth, Tex.)
core   +1 more source

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