Results 51 to 60 of about 11,149 (212)

Microfluidic Hydroporation Platform for Effective Allogeneic CAR‐T Cell Production and Subsequent Functional Cytotoxicity Analysis

Advanced Materials Technologies, EarlyView.
The hydroporator platform employs controlled hydrodynamic deformation for efficient mRNA and CRISPR/Cas9 delivery into primary human T cells, enabling allogeneic CAR‐T cell manufacturing. It preserves cell functionality and drives potent gene editing, CAR expression, and tumor cytotoxicity, while feature‐based analysis links these functional outcomes ...
Soohyun Jeon, Sein Kim, Hyun‐Young Kim, Duck Cho, Sungsu Park, Seohyun Kim, Aram J. Chung   +6 more
wiley   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Taxonomic revision of Eoalligator (Crocodylia, Brevirostres) and the paleogeographic origins of the Chinese alligatoroids [PDF]

PeerJ, 2016
Background. The primarily Neotropical distribution of living alligatoroids raises questions as to when and how the ancestors of Alligator sinensis migrated to China.
Yan-yin Wang, Corwin Sullivan, Jun Liu
doaj   +2 more sources

Decoding Structure‐Property Relationships in Anion Exchange Membranes via a Chemically Informed Dual‐Channel Graph Attention Network

Advanced Science, EarlyView.
SPARK decodes structure‐property relationships in anion exchange membranes (AEMs) via a chemically informed dual‐channel graph attention network (DEGAT) that explicitly captures microphase separation. It outputs five‐level grades for hydroxide conductivity and alkaline stability and highlights relevant key structural units, enabling robust pre ...
Wanting Chen, Ye Hu, Zijun Xiao, Deming Xia, Bo Pang, Xuemei Wu, Gaohong He   +6 more
wiley   +1 more source

A Mutual Information Based Sequence Distance For Vertebrate Phylogeny Using Complete Mitochondrial Genomes [PDF]

, 2007
Traditional sequence distances require alignment. A new mutual information based sequence distance without alignment is defined in this paper. This distance is based on compositional vectors of DNA sequences or protein sequences from complete genomes ...
Anh, Vo, Mao, Z, Yu, Zuguo, Zhou, Li-Qian   +3 more
core   +2 more sources

Trump Tariffs 2.0: Assessing the Impacts on US Distilled Spirits Imports

Agribusiness, EarlyView.
ABSTRACT The proposed 25% tariff on Mexico and Canada could have significant repercussions on US imports of distilled spirits. This study estimates US import demand across various spirit categories (e.g., tequila, whiskey) and assesses the potential impact of the proposed tariff.
Andrew Muhammad
wiley   +1 more source

Draft Genome of the Leopard Gecko, \u3cem\u3eEublepharis Macularius\u3c/em\u3e [PDF]

, 2016
Background Geckos are among the most species-rich reptile groups and the sister clade to all other lizards and snakes. Geckos possess a suite of distinctive characteristics, including adhesive digits, nocturnal activity, hard, calcareous eggshells, and a
Gamble, Tony, Kui, Ling, Li, Cai, Li, Fang, Li, Shengbin, Xiong, Zijun, Yang, Huanming, Zhang, Guojie, Zheng, Jiao, Zhou, Long   +9 more
core   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective

Advanced Intelligent Discovery, EarlyView.
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley   +1 more source

Using lentiviral to investigate the effect of novel candidate gene MAEL identified by RNA-seq on sex differentiation in the Chinese Alligator (Alligator sinensis)

Aquaculture Reports
The sex differentiation of Chinese alligator displays temperature-dependent sex determination, which occurs in the temperature-sensitive period (TSP) of embryonic development. Despite studies identifying genes involved in sex determination in the Chinese
Yue Wen, Lilei Lu, Changcheng Li, Fuyong You, Yunlu Xu, Haitao Nie, Xiaobing Wu   +6 more
doaj   +1 more source