Results 91 to 100 of about 4,594 (185)

Subnormothermic Perfusion in the Isolated Rat Liver Preserves the Antioxidant Glutathione and Enhances the Function of the Ubiquitin Proteasome System. [PDF]

, 2016
The reduction of oxidative stress is suggested to be one of the main mechanisms to explain the benefits of subnormothermic perfusion against ischemic liver damage. In this study we investigated the early cellular mechanisms induced in isolated rat livers
Alva, Norma, Carbonell, Teresa, Dewey, Shannamar, Gomes, Aldrin V, Sanchez-Nuño, Sergio   +4 more
core   +4 more sources

Lactobacillus Salivarius‐Derived Indole‐3‐Acetic Acid Promotes AHR‐PARP1 Axis‐Mediated DNA Repair to Mitigate Intestinal Aging

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Indole‐3‐acetic acid (IAA) acting as one of the aryl hydrocarbon receptor (AHR) endogenous ligands is identified to be derived from Lactobacillus salivarius via its catalytic enzyme (ALDH) rather than host cells. Lactobacillus salivarius and IAA supplementation effectively mitigate intestinal aging by facilitating AHR‐poly (ADP‐ribose) polymerase 1 ...
Zheng Cao, Cui Zhang, Hehua Lei, Weichuan Lin, Wenkai Yu, Xin Gao, Yanmeng He, Xinzhi Li, Qingwei Xiang, Zhiwen Zhang, Weifei Luo, Andrew D. Patterson, Limin Zhang, Gang Chen   +13 more
wiley   +1 more source

Genetic associations with longevity are on average stronger in females than in males

Heliyon
It is long observed that females tend to live longer than males in nearly every country. However, the underlying mechanism remains elusive. In this study, we discovered that genetic associations with longevity are on average stronger in females than in ...
Yi Zeng, Huashuai Chen, Xiaomin Liu, Zijun Song, Yao Yao, Xiaoyan Lei, Xiaozhen Lv, Lingguo Cheng, Zhihua Chen, Chen Bai, Zhaoxue Yin, Yuebin Lv, Jiehua Lu, Jianxin Li, Kenneth C. Land, Anatoliy Yashin, Angela M. O'Rand, Liang Sun, Ze Yang, Wei Tao, Jun Gu, William Gottschalk, Qihua Tan, Kaare Christensen, Therese Hesketh, Xiao-Li Tian, Huanming Yang, Viviana Egidi, Graziella Caselli, Jean-Marie Robine, Huali Wang, Xiaoming Shi, James W. Vaupel, Michael W. Lutz, Chao Nie, Junxia Min   +35 more
doaj   +1 more source

Canonical Correlation Analysis on the Association Between Sleep Quality and Nutritional Status Among Centenarians in Hainan

Frontiers in Public Health, 2020
Objective: To analyze the correlation between nutritional status and sleep quality among centenarians.Methods: A total of 1,002 centenarians in Hainan were included in the full sample survey.
Guangdong Liu, Shanshan Yang, Wei Liu, Shengshu Wang, Penggang Tai, Fuyin Kou, Wangping Jia, Ke Han, Miao Liu, Yao He   +9 more
doaj   +1 more source

Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review

Medicine Bulletin, Volume 2, Issue 1, Page 94-123, January 2026.
ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng, Rui Li, Huan Li, Jun Zhou, Xuanshi Liu, Guilherme Valente, Tatiana de Campos Melo, Sifan Chen, Lei Gu   +8 more
wiley   +1 more source

Association of late childbearing with healthy longevity among the oldest-old in China [PDF]

Statistical analysis of a large and unique longitudinal data set demonstrates that late childbearing after age 35 or 40 is significantly associated with survival and healthy survival among very old Chinese women and men.
James W. Vaupel, Yi Zeng
core  

Environmental conditions during early life accelerate the rate of senescence in a short-lived passerine bird [PDF]

, 2015
Environmental conditions experienced in early life may shape subsequent phenotypic traits including life history. We investigated how predation risk caused by domestic cats (Felis silvestris catus) and local breeding density affected patterns of ...
Balbontín Arenas, Javier, Møller, Anders P.   +1 more
core   +2 more sources

G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old

Scientific Reports, 2018
Frailty is characterized by a decline in physiological reserve and increased vulnerability. Previous studies have shown that KLOTHO (KL) plays a protective role in several age-related diseases. We hypothesize a probable protective effect of KL on frailty
Qiukui Hao, Yuting Wang, Xiang Ding, Biao Dong, Ming Yang, Birong Dong, Yuquan Wei   +6 more
doaj   +1 more source

Relationship Between Fecal Bile Acid Profile and Intestinal Microbiota in Patients With Chronic Radiation Enteritis

Journal of Digestive Diseases, Volume 27, Issue 1-2, Page 40-49, January-February 2026.
Patients with chronic radiation enteritis (CRE) demonstrate dysregulated bile acid (BA) metabolism, characterized by an increased proportion of primary BAs and a decreased proportion of secondary BAs. Moreover, the diversity of the intestinal microbiota is significantly reduced in individuals with CRE, and there is a bidirectional interaction between ...
Xin Shen, Song Bo Li, Meng Jie Gao, Jiao Jiao Cao, Hua Yang, Wei Wei Li, Li Chun Wei, Min Chen, Jun Ye Liu, Yong Quan Shi   +9 more
wiley   +1 more source

Oldest Old Mortality in China [PDF]

We find that the Kannisto model, a two-parameter logistic formula, fits Han Chinese death rates at oldest-old ages better than the Gompertz and four other models. Chinese death rates appear to be roughly similar to Swedish and Japanese rates after age 97
James W. Vaupel, Yi Zeng
core