Screening Strategies for High-Yield Chinese Hamster Ovary Cell Clones [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 Chinese hamster ovary (CHO) cells are by far the most commonly used mammalian expression system for recombinant expression of therapeutic proteins in the pharmaceutical industry.
Wenwen Yang +8 more
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4-(2,5-Dimethyl-1H-pyrrol-1-yl)-N-(2,5-dioxopyrrolidin-1-yl) benzamide improves monoclonal antibody production in a Chinese hamster ovary cell culture. [PDF]
PLoS ONE, 2021 There is a continuous demand to improve monoclonal antibody production for medication supply and medical cost reduction. For over 20 years, recombinant Chinese hamster ovary cells have been used as a host in monoclonal antibody production due to ...
Yuichi Aki +4 more
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Chinese hamster ovary cell line DXB-11: chromosomal instability and karyotype heterogeneity [PDF]
Molecular Cytogenetics, 2021 Background Chinese hamster ovary cell lines, also known as CHO cells, represent a large family of related, yet quite different, cell lines which are metabolic mutants derived from the original cell line, CHO-ori.
Victoria I. Turilova +2 more
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Genetic drivers of Chinese hamster ovary cell proliferation revealed by functional genomics [PDF]
iScienceSummary: Cell lines used in biopharmaceutical manufacturing are engineered to optimize protein yield, quality, and production speed. Cellular growth rate is a key bottleneck in the development of biopharmaceutical production cell lines.
Jannis Marzluf +4 more
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Comparative omics profiling reveals differences in biomass, energy production, and vesicle transport between CHO and fast-growing CHL-YN cells [PDF]
Scientific ReportsChinese hamster lung (CHL)-YN cells are promising novel hosts for producing therapeutic antibodies with the potential to shorten the research, development, and manufacturing timelines in biopharmaceutical production.
Yu Tsunoda +6 more
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Mono-CYP CHO Model: A Recombinant Chinese Hamster Ovary Cell Platform for Investigating CYP-Specific Tamoxifen Metabolism. [PDF]
Int J Mol SciSchulz C, Stegen S, Jung F, Küpper JH.
europepmc +3 more sources
The Chinese Hamster Ovary Cell-Based H9 HA Subunit Avian Influenza Vaccine Provides Complete Protection against the H9N2 Virus Challenge in Chickens. [PDF]
VirusesZhu S +9 more
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Data in Brief, 2020 The data presented in this article relates to the manuscript entitled ‘Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production’, published in the Journal Metabolic ...
James D. Budge +11 more
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Generation of induced pluripotent stem cells from Chinese hamster embryonic fibroblasts
Stem Cell Research, 2017 We derived a stable cell line from Chinese hamster embryonic fibroblasts by transduction of four mouse transcription factors (M3O, Sox2, Klf4, and n-Myc) using a lentiviral vector.
Haiyun Pei +7 more
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Sterilization of PAN/Gelatine Nanofibrous Mats for Cell Growth [PDF]
Tekstilec, 2019 Nanofibrous mats can be used as a substrate for eukaryotic cell growth in biotechnology, tissue engineering, etc. Several adherent cells (e.g. human fibroblasts) have been shown to grow well on fine fibres.
Daria Wehlage +8 more
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