Screening Strategies for High-Yield Chinese Hamster Ovary Cell Clones [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 Chinese hamster ovary (CHO) cells are by far the most commonly used mammalian expression system for recombinant expression of therapeutic proteins in the pharmaceutical industry.
Wenwen Yang +8 more
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4-(2,5-Dimethyl-1H-pyrrol-1-yl)-N-(2,5-dioxopyrrolidin-1-yl) benzamide improves monoclonal antibody production in a Chinese hamster ovary cell culture. [PDF]
PLoS ONE, 2021 There is a continuous demand to improve monoclonal antibody production for medication supply and medical cost reduction. For over 20 years, recombinant Chinese hamster ovary cells have been used as a host in monoclonal antibody production due to ...
Yuichi Aki +4 more
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Chinese hamster ovary cell line DXB-11: chromosomal instability and karyotype heterogeneity [PDF]
Molecular Cytogenetics, 2021 Background Chinese hamster ovary cell lines, also known as CHO cells, represent a large family of related, yet quite different, cell lines which are metabolic mutants derived from the original cell line, CHO-ori.
Victoria I. Turilova +2 more
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Using molecular markers to characterize productivity in Chinese hamster ovary cell lines. [PDF]
PLoS ONE, 2013 Selection of high producing cell lines to produce maximum product concentration is a challenging and time consuming task for the biopharmaceutical industry.
Raihana Z Edros +2 more
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A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism. [PDF]
Cell Syst, 2016 Hefzi H +39 more
europepmc +2 more sources
Sterilization of PAN/Gelatine Nanofibrous Mats for Cell Growth [PDF]
Tekstilec, 2019 Nanofibrous mats can be used as a substrate for eukaryotic cell growth in biotechnology, tissue engineering, etc. Several adherent cells (e.g. human fibroblasts) have been shown to grow well on fine fibres.
Daria Wehlage +8 more
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Acute Toxic and Genotoxic Effects of Aluminum and Manganese Using In Vitro Models
Toxics, 2021 The objective of this study was to use the same concentrations of aluminum (Al) and manganese (Mn) detected previously in groundwater above those permitted by Brazilian law and assess their cytotoxic and genotoxic effects in hamster ovary cell lines and ...
Luiza Flavia Veiga Francisco +8 more
doaj +1 more source
Enhancing the toolbox to study IL-17A in cattle and sheep
Veterinary Research, 2017 The development of methods to detect cytokine expression by T cell subsets in ruminants is fundamental to strategic development of new livestock vaccines for prevention of infectious diseases. It has been possible to detect T cell expression of IFN-γ, IL-
Sean R. Wattegedera +9 more
doaj +1 more source
A Metabolomics Approach to Increasing Chinese Hamster Ovary (CHO) Cell Productivity
Metabolites, 2021 Much progress has been made in improving the viable cell density of bioreactor cultures in monoclonal antibody production from Chinese hamster ovary (CHO) cells; however, specific productivity (qP) has not been increased to the same degree. In this work,
Grace Yao +5 more
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