Results 91 to 100 of about 128,450 (211)

Generation of Flp-intm-ready DG44 and Lec 3.2.8.1 CHO cell lines for quick and easy constitutive protein expression

BioTechniques, 2018
The well-characterized cell line Chinese hamster ovary (CHO) has been used to produce numerous biopharmaceuticals and is an important tool for basic research. However, introducing foreign DNA into specially modified CHO cells such as DG44 and Lec 3.2.8.1
DC Soler, AE Young, A Vahedi-Faridi, TS McCormick   +3 more
doaj   +1 more source

New high-throughput screening method for Chinese hamster ovary cell lines expressing low reduced monoclonal antibody levels: application of a system controlling the gas phase over cell lysates in miniature bioreactors and facilitating multiple sample setup. [PDF]

Cytotechnology, 2023
Yamaguchi T, Fukuda M, Matsumoto Y, Mori T, Kikuchi S, Nagano R, Yamamoto K, Wakamatsu K.   +7 more
europepmc   +1 more source

Systems Biology of Recombinant 2G12 and 353/11 mAb Production in CHO-K1 Cell Lines at Phosphoproteome Level

Proteomes
Background: Chinese hamster ovary (CHO) cells are extensively used in the pharmaceutical industry for producing complex proteins, primarily because of their ability to perform human-like post-translational modifications.
Eldi Sulaj, Felix L. Sandell, Linda Schwaigerlehner, Gorji Marzban, Juliane C. Dohm, Renate Kunert   +5 more
doaj   +1 more source

High-resolution three-dimensional chromatin profiling of the Chinese hamster ovary cell genome. [PDF]

Biotechnol Bioeng, 2021
Bevan S, Schoenfelder S, Young RJ, Zhang L, Andrews S, Fraser P, O'Callaghan PM.   +6 more
europepmc   +1 more source

Aging Concept in Population Dynamics [PDF]

arXiv, 2003
Author's early work on aging is developed to yield a relationship between life spans and the velocity of aging. The mathematical analysis shows that the mean extent of the advancement of aging throughout one's life is conserved, or equivalently, the product of the mean life span, and the mean rate of aging is constant. The result is in harmony with our
arxiv  

DNA replication in Chinese hamster ovary cells made permeable to nucleotides by tween-80 treatment. [PDF]

, 1976
Daniel Billen, Ann C. Olson
openalex   +1 more source

Biopharmaceutical-Type Chinese Hamster Ovary Cell Cultivation Under Static Magnetic Field Exposure: A Study of Genotoxic Effect. [PDF]

Front Bioeng Biotechnol, 2021
Rekena A, Livkisa D, Kamolins E, Vanags J, Loca D.   +4 more
europepmc   +1 more source

What can mathematical modelling say about CHO metabolism and protein glycosylation?

Computational and Structural Biotechnology Journal, 2017
Chinese hamster ovary cells have been in the spotlight for process optimization in recent years, due to being the major, long established cell factory for the production of recombinant proteins.
Sarah N. Galleguillos, David Ruckerbauer, Matthias P. Gerstl, Nicole Borth, Michael Hanscho, Jürgen Zanghellini   +5 more
doaj  

Protocol for cell-based screening assay to measure ERK1/2 phosphorylation as a readout for complement receptor activation

STAR Protocols, 2023
Summary: The complement receptors C3aR and C5aR1 are promising therapeutic targets. Here, we present a protocol to screen the effects of different agonists and antagonists on these receptors in vitro, using phosphorylated extracellular signal-regulated ...
Xaria X. Li, Trent M. Woodruff
doaj  

Differences in β-naphthylamine metabolism and toxicity in Chinese hamster ovary cell lines transfected with human CYP1A2 and NAT2*4, NAT2*5B or NAT2*7B N-acetyltransferase 2 haplotypes. [PDF]

Arch Toxicol, 2022
Habil MR, Salazar-González RA, Doll MA, Hein DW.   +3 more
europepmc   +1 more source