Results 111 to 120 of about 110,281 (284)

Precision mRNA Delivery via Ultrasound‐Controlled Release Perfluorocarbon Emulsions: An Innovative Ultrasound Theranostic Strategy with 19F MRI Feasibility

Small, EarlyView.
A key challenge in advancing messenger RNA (mRNA) therapeutics in cardiovascular diseases lies in achieving controlled release at the precise site within the vasculature. This study presents the development of perfluorocarbon nanodroplets with exceptional theranostic potential, enabling real‐time tracking through ultrasound and fluorine‐19 (19F ...
Haikun Liu, Mark Louis P. Vidallon, Yuyang Song, Aidan P. G. Walsh, Henry Gordon, Shulei Ren, Pengkai Shi, Bangyan Xu, Mitchell J. Moon, Sylvain Trépout, Rico F. Tabor, Alexis I. Bishop, Ulrich Flögel, Karlheinz Peter, Xiaowei Wang   +14 more
wiley   +1 more source

Machine Learning and Deep Learning Strategies for Chinese Hamster Ovary Cell Bioprocess Optimization

Fermentation
The use of machine learning and deep learning has become prominent within various fields of bioprocessing for countless modeling and prediction tasks.
Tiffany-Marie D. Baako, Sahil Kaushik Kulkarni, Jerome L. McClendon, Sarah W. Harcum, Jordon Gilmore   +4 more
doaj   +1 more source

Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis[S]

Journal of Lipid Research, 2014
The role of signaling in regulating cholesterol homeostasis is gradually becoming more widely recognized. Here, we explored how kinases and phosphorylation sites regulate the activity of the enzyme involved in the final step of cholesterol synthesis, 3β ...
Winnie Luu, Eser J. Zerenturk, Ika Kristiana, Martin P. Bucknall, Laura J. Sharpe, Andrew J. Brown   +5 more
doaj   +1 more source

Preclinical Toxicity Screening of Sodium Dodecanoyloxybenzenesulfonate (LOBS) as a New Alternative Biocide Using In Vitro and In Vivo Models

Environmental Toxicology, EarlyView.
ABSTRACT Sodium hypochlorite is a well‐established biocide extensively used in both living and industrial environments; however, exposure to it or improper handling can harm the human body and the environment. Thus, safer alternatives to sodium hypochlorite are required.
Seung Eui Min, Seunghee Oh, Min Seong Jang, Kang‐Hyun Han   +3 more
wiley   +1 more source

Hsp27 anti-sense oligonucleotides sensitize the microtubular cytoskeleton of Chinese hamster ovary cells grown at low pH to 42 degrees C-induced reorganization [PDF]

, 2004
Chinese hamster ovary (CHO) cells maintained in vitro at pH 6.7 were used to model cells in the acidic environment of tumours. CHO cells grown at pH 6.7 develop thermotolerance during 42 degrees C heating at pH 6.7 and their cytoskeletal systems are ...
Coss, Ronald A., Hargis, Michael T., Leeper, Dennis B., Storck, C. W., Wickstrom, Eric, Yakubov, Leonid A.   +5 more
core   +1 more source

Cancer‐Specific Antihuman Podoplanin Antibody chLpMab‐2f Exerts Antitumor Effects Against Pleural Mesothelioma

Cancer Science, EarlyView.
Cancer‐specific antihuman podoplanin antibody chLpMab‐2f exerted antibody‐dependent cellular cytotoxicity and complement‐dependent cytotoxicity against pleural mesothelioma (PM) cell lines. Additionally, chLpMab‐2f inhibited tumor progression in mice with subcutaneously and intrathoracically transplanted human PM cells.
Aito Yoshida, Shinji Abe, Toshihiro Izumi, Satoshi Itakura, Keichiro Yamada, Takuya Wada, Takaaki Yamamoto, Chiemi Sato, Atsushi Mitsuhashi, Hirokazu Ogino, Seidai Sato, Tsutomu Shinohara, Masaki Hanibuchi, Mika K. Kaneko, Yukinari Kato, Yasuhiko Nishioka   +15 more
wiley   +1 more source

THE DEVELOPMENT OF A PRODUCTION SCALE TECHNOLOGY OF RECOMBINANT FOLLICLE STIMULATING HORMONE BIOPROCESS IN CHO CELL LINE

Разработка и регистрация лекарственных средств, 2019
The article discusses the development of a production technique for recombinant follicle-stimulating hormone used in the treatment of infertility, in the culture of Chinese hamster ovary cells.
D. A. Gusarov, A. I. Gosudarev, V. D. Gusarova, D. V. Byrikhina, F. M. Izhaeva   +4 more
doaj  

Kinetic and structural characterisation of domain‐specific angiotensin I‐converting enzyme inhibition by captopril, rentiapril and zofenoprilat

The FEBS Journal, EarlyView.
Angiotensin I‐converting enzyme (ACE) contains two catalytic domains (nACE and cACE) and is a key therapeutic target for hypertension and cardiovascular disease. Current ACE inhibitors (ACEi) nonselectively inhibit both domains, causing adverse effects. Selective inhibition requires an understanding of domain‐specific binding.
Kyle S. Gregory, Vinasha Ramasamy, Edward D. Sturrock, K. Ravi Acharya   +3 more
wiley   +1 more source

The polarized expression of Na+,K+-ATPase in epithelia depends on the association between beta-subunits located in neighboring cells [PDF]

, 2005
The polarized distribution of Na+,K+-ATPase plays a paramount physiological role, because either directly or through coupling with co- and countertransporters, it is responsible for the net movement of, for example, glucose, amino acids, Ca2+, K+, Cl ...
Balda, MS, Cereijido, M, Contreras, RG, Lazaro, A, Matter, K, Moreno, J, Roldan, ML, Shoshani, L   +7 more
core  

Network reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data [PDF]

, 2017
BACKGROUND: Protein secretion is one of the most important processes in eukaryotes. It is based on a highly complex machinery involving numerous proteins in several cellular compartments.
Andersen, Mikael Rørdam, Brandl, Julian, Kaas, Christian Schrøder, Kildegaard, Helene Faustrup, Kristensen, Claus, Lund, Anne Mathilde, Pedersen, Lasse Ebdrup   +6 more
core   +3 more sources