Results 131 to 140 of about 110,281 (284)
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION Microglia are macrophage‐like brain resident immune cells known to express numerous Alzheimer's disease risk genes. Here we generated a human induced pluripotent stem cell (iPSC) derived microglia cell culture model for use in neuroimmune modeling and therapeutic testing.
Angela K. Haskell +16 more
wiley +1 more source
Animal Research and One Health, Volume 4, Issue 1, Page 105-119, February 2026.Multi‐omics analysis revealed that FOS supplementation increased the abundance of Phascolarctobacterium, GCA‐900066575, Shuttleworthia, Olsenella, Eubacterium_hallii_group while decreasing Alistipes. It also influenced the metabolism of S‐lactoylglutathione, p‐cresol glucuronate, 2‐phenylethanol glucuronide, propionic acid, dulcitol, and inhibited the ...
Dan Song +11 more
wiley +1 more source
Rapid Identification of Chinese Hamster Ovary Cell Apoptosis and Its Potential Role in Process Robustness Assessment. [PDF]
Bioengineering (Basel), 2023 Xiao S +5 more
europepmc +1 more source
Hyperosmolarity enhances transient recombinant protein yield in Chinese hamster ovary cells [PDF]
, 2018 The effect of hyperosmolarity on transient recombinant protein production in Chinese hamster ovary (CHO) cells was investigated. Addition of 90mM NaCl to the production medium ProCHO5 increased the volumetric yield of recombinant antibody up to 4-fold ...
Baldi, Lucia +4 more
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Biotechnology and Bioengineering, Volume 123, Issue 2, Page 324-336, February 2026.ABSTRACT In‐line Raman spectroscopy combined with accurate quantification models can offer detailed real‐time insights into a bioprocess by monitoring key process parameters. However, traditional approaches for model calibration require extensive data collection from multiple bioreactor runs, resulting in process‐specific models that are sensitive to ...
Maarten Klaverdijk +3 more
wiley +1 more source
Biotechnology and Bioengineering, Volume 123, Issue 2, Page 406-419, February 2026.A platform approach to the affinity capture and enrichment of host cell proteins to enable their subsequent deep characterization and elucidation of variants or proteoforms (e.g., molecular size variants, charge variants, glycoforms, etc.). ABSTRACT Removing host cell proteins (HCPs) during biotherapeutic manufacturing is essential to ensure patient ...
Michael E. Dolan +6 more
wiley +1 more source
Online deployment of an O-PLS model for dielectric spectroscopy-based inline monitoring of viable cell concentrations in Chinese hamster ovary cell perfusion cultivations. [PDF]
Eng Life Sci, 2023 Lemke J, Söldner R, Austerjost J.
europepmc +1 more source
Comparative Analysis of HEK293 Genomic Variability
Biotechnology and Bioengineering, Volume 123, Issue 2, Page 436-448, February 2026.An investigation of how HEK293‐derived cell lines adapt genetically to different culture conditions and environmental pressures: despite distinct phenotypes and cultivation histories, comparative whole‐genome analyses of established HEK293 variants as well as newly suspension‐adapted cells revealed a shared, common set of mutations linked to cell ...
Georg Smesnik +4 more
wiley +1 more source
Performance Comparison between Semi‐Automated and Manual Cell Counting for Animal Cell Culture
Chemie Ingenieur Technik, Volume 98, Issue 1-2, Page 57-63, February 2026.Following ISO 20391‐2:2019 guidelines, manual and semi‐automated cell counting performances were compared using validation parameters from ICH Q2(R1). Specificity, linearity, and repeatability served as key validation parameters in the evaluation of total cell density and cell viability of CHO‐K1 cells using trypan blue exclusion staining.
Selina Uhlendorff +3 more
wiley +1 more source
Dynamics of Amino Acid Metabolism, Gene Expression, and Circulomics in a Recombinant Chinese Hamster Ovary Cell Line Adapted to Moderate and High Levels of Extracellular Lactate. [PDF]
Genes (Basel), 2023 Chitwood DG +5 more
europepmc +1 more source