Results 141 to 150 of about 110,281 (284)

Exploring CPP Enhanced Hypoxia Targeting: An Approach Using Radiolabeled 2‐nitroimidazole TAT Conjugate

Drug Development Research, Volume 87, Issue 1, February 2026.
ABSTRACT Mediated by their protein transduction domain, cell‐penetrating peptides (CPPs) have been widely explored for facilitating intracellular delivery of drugs and small molecules. In this study, a radiolabeled, 2‐nitroimidazole conjugated TAT (TAT ‐ transactivator of transcription) peptide was prepared and evaluated for targeting tumor hypoxia ...
Sweety Mittal, Akanksha Jain, Ashwini Babu, Chandan Kumar, Madhava B. Mallia   +4 more
wiley   +1 more source

Systems Biology of Recombinant 2G12 and 353/11 mAb Production in CHO-K1 Cell Lines at Phosphoproteome Level

Proteomes
Background: Chinese hamster ovary (CHO) cells are extensively used in the pharmaceutical industry for producing complex proteins, primarily because of their ability to perform human-like post-translational modifications.
Eldi Sulaj, Felix L. Sandell, Linda Schwaigerlehner, Gorji Marzban, Juliane C. Dohm, Renate Kunert   +5 more
doaj   +1 more source

High-resolution three-dimensional chromatin profiling of the Chinese hamster ovary cell genome. [PDF]

Biotechnol Bioeng, 2021
Bevan S, Schoenfelder S, Young RJ, Zhang L, Andrews S, Fraser P, O'Callaghan PM.   +6 more
europepmc   +1 more source

Tetravalent antibodies are more potent and efficacious erythropoiesis‐stimulating agents than erythropoietin in vivo

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Recent studies have shown that tetravalent antibodies are potent and efficacious agonists of the erythropoietin (EPO) receptor (EPOR) both in vitro and in vivo. To identify antibody‐based erythropoiesis‐stimulating agents (ESAs) with therapeutic potential, we evaluated various tetravalent antibody formats for EPOR agonism and key biophysical ...
Jarrett J. Adams, Levi L. Blazer, Jacky Chung, Minoo Karimi, Taylor Davidson, Bailey Blair, Carlos Waddle, Craig A. Hokanson, Heather A. Bruce, Alexander U. Singer, Eva‐Maria Tombak, Kiira Gildemann, Nele Tamberg, Kaja Kiiver, Mart Ustav Jr, Yue Ma, Luigi Colombo, Lily Jun‐Shen Huang, Stephen W. Michnick, Orson W. Moe, Sachdev S. Sidhu   +20 more
wiley   +1 more source

New high-throughput screening method for Chinese hamster ovary cell lines expressing low reduced monoclonal antibody levels: application of a system controlling the gas phase over cell lysates in miniature bioreactors and facilitating multiple sample setup. [PDF]

Cytotechnology, 2023
Yamaguchi T, Fukuda M, Matsumoto Y, Mori T, Kikuchi S, Nagano R, Yamamoto K, Wakamatsu K.   +7 more
europepmc   +1 more source

A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism.

Cell Systems, 2016
Hooman Hefzi, Kok Siong Ang, Michael Hanscho, A. Bordbar, David E. Ruckerbauer, Meiyappan Lakshmanan, C. Orellana, Deniz Baycin-Hizal, Yingxiang Huang, Daniel Ley, Verónica S. Martínez, Sarantos Kyriakopoulos, Natalia E. Jiménez, Daniel C. Zielinski, L. Quek, T. Wulff, Johnny Arnsdorf, Shangzhong Li, Jae Seong Lee, G. Paglia, N. Loira, Philipp N Spahn, L. Pedersen, Jahir M. Gutierrez, Zachary A. King, A. Lund, Harish Nagarajan, A. Thomas, Alyaa M. Abdel-Haleem, J. Zanghellini, H. F. Kildegaard, B. Voldborg, Z. Gerdtzen, M. Betenbaugh, B. Palsson, M. Andersen, L. Nielsen, N. Borth, Dong-Yup Lee, N. Lewis   +39 more
semanticscholar   +1 more source

Zinc‐Mediated Lysosomal Destabilization Links Mitochondrial Damage to Neuronal Death in a Cellular MPP+ Model of Parkinson's Disease

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
When mitochondria are damaged by MPP+, they produce excess reactive oxygen species (ROS) and release zinc (Zn2+) inside the cell. This surge in zinc overwhelms lysosomes—the cell's major zinc‐buffering organelles—causing their membranes to break down. Leaking lysosomal enzymes then trigger neuronal death. Treatments that reduce ROS, bind zinc, or block
Hyun‐Seung Lee, Sun‐Ah Kang, Jae‐Won Eom, Min Seong Kim, Ji‐Soo Kim, Yang‐Hee Kim   +5 more
wiley   +1 more source

Biopharmaceutical-Type Chinese Hamster Ovary Cell Cultivation Under Static Magnetic Field Exposure: A Study of Genotoxic Effect. [PDF]

Front Bioeng Biotechnol, 2021
Rekena A, Livkisa D, Kamolins E, Vanags J, Loca D.   +4 more
europepmc   +1 more source

Peer review of the pesticide risk assessment of the active substance paraffin oil (CAS 72623‐86‐0, chain lengths C19–C28)

EFSA Journal, Volume 24, Issue 2, February 2026.
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Greece, and co‐rapporteur Member State, France, for the pesticide active substance paraffin oil (CAS 72623‐86‐0) are reported.
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Amarela Becirovic, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Mark Egsmose, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Katrin Halling, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Mariano Lopez Romano, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza   +48 more
wiley   +1 more source

Differences in β-naphthylamine metabolism and toxicity in Chinese hamster ovary cell lines transfected with human CYP1A2 and NAT2*4, NAT2*5B or NAT2*7B N-acetyltransferase 2 haplotypes. [PDF]

Arch Toxicol, 2022
Habil MR, Salazar-González RA, Doll MA, Hein DW.   +3 more
europepmc   +1 more source