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Chinese hamster ovary cell mutants affecting cholesterol metabolism
Current Opinion in Lipidology, 1997The approach of somatic cell and molecular genetics for the study of intracellular regulation of cholesterol metabolism has blossomed in recent years. This review lists all the Chinese hamster ovary cell mutants involved in cholesterol metabolism.
Chang, T. +5 more
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Acetylation of spermidine in Chinese hamster ovary cells
Biochemical and Biophysical Research Communications, 1980Summary Incubation of Chinese hamster ovary (CHO) cells with [14C]spermidine resulted in a linear uptake of radiolabel over a 24-h period. Qualitative analysis of the [14C]metabolites present in the cells demonstrated the formation of both N1- and N8-acetylspermidine.
C E, Prussak, D H, Russell
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Hyperthermic Radiosensitization of Thermotolerant Chinese Hamster Ovary Cells
Radiation Research, 1986Synchronous G1 cells were given a priming dose of heat (45.5 degrees C for 15 min) and then heated and irradiated 6-120 h later. Compared to heat radiosensitization for cells irradiated 10 min after the priming heat dose (thermal enhancement ratio, TER of 2.6 for a 10-fold reduction in survival), heat radiosensitization 18-24 h after the priming heat ...
P K, Holahan +3 more
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Developing genomic platforms for Chinese hamster ovary cells
Biotechnology Advances, 2009Chinese hamster ovary (CHO) cells are widely used in recombinant protein production, yet despite their importance in bioprocessing, few genomic resources have been developed for this cell line. Over the past several years, we have made considerable progress in the development of genomic tools for CHO.
Anne, Kantardjieff +7 more
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Nucleoside kinase activities of Chinese hamster ovary cells
Biochimica et Biophysica Acta (BBA) - General Subjects, 1983Chinese hamster ovary (CHO) cells and appropriate drug-resistant mutants derived from them have been analyzed for nucleoside kinase activities relevant to the phosphorylation of adenosine, deoxyadenosine, deoxyguanosine and deoxycytidine and for resistance to a variety of nucleoside analogs.
P P, Saunders, M M, Lai
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Biallelic Gene Knockouts in Chinese Hamster Ovary Cells
2008Chinese hamster ovary (CHO) cells are the most common host cells and are widely used in the manufacture of approved recombinant therapeutics. They represent a major new class of universal hosts in biopharmaceutical production. However, there remains room for improvement to create more ideal host cells that can add greater value to therapeutic ...
Naoko, Yamane-Ohnuki +2 more
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Optical binding of Chinese hamster ovary cells
SPIE Proceedings, 2005Optical binding may arise due to interplay between light scattering and refraction creating equilibrium positions for particles in a self-consistent manner. Binding is observed for the first time in biological cells within a dual beam fiber trap.
N. K. Metzger +4 more
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[1] Chinese hamster ovary cells
1987Publisher Summary This chapter describes Chinese hamster ovary (CHO) cells that use for genetic analysis in tissue culture. These cells have been used for the isolation of mutants affecting intermediary metabolism; DNA, RNA, and protein synthesis; membrane functions; and several more complex forms of cell behavior such as cell growth and endocytosis.
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Cell Engineering and Cultivation of Chinese Hamster Ovary (CHO) Cells
Current Pharmaceutical Biotechnology, 2010Mammalian cell lines are important host cells for the industrial production of pharmaceutical proteins owing to their capacity for correct folding, assembly and post-translational modification. In particular, Chinese hamster ovary (CHO) cells are the most dependable host cells for the industrial production of therapeutic proteins.
Takeshi, Omasa +2 more
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[Modification of Chinese hamster ovary cells].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2002Chinese hamster ovary cells (CHO) are preferable to prokaryotic, yeast or insect cells as hosts for biopharmaceutical production due to the products are more similar to their natural conformation. However, CHO cells confront tremendous difficulties when cultured in large scale such as mal-adaptation to serum-free medium, apoptosis and over-growth ...
Da-Zhi, Lai +4 more
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