Results 81 to 90 of about 128,450 (211)

On the biophysical interpretation of lethal DNA lesions induced by ionizing radiation [PDF]

arXiv, 2005
Although DNA damage is widely viewed as a critical target for the induction of cell killing by ionizing radiation, the exact nature of DNA damage responsible for these effects is unknown. To address this issue, the probability of forming lethal damage by single proton tracks, derived from published survival data for Chinese hamster V79 cells irradiated
arxiv  

Functional characterization of oligopeptide transporter 1 of dairy cows

Journal of Animal Science and Biotechnology, 2018
Background It is well known that peptides play a vital role in the nutrition and health of dairy cows. Bovine oligopeptide transporter 1 (bPepT1) is involved in the peptide transport process in the gastrointestinal tracts of dairy cows.
Qingbiao Xu, Zhixuan Liu, Hongyun Liu, Fengqi Zhao, Xinbei Huang, Yueming Wu, Jianxin Liu   +6 more
doaj   +1 more source

Novel column generation-based optimization approach for poly-pathway kinetic model applied to CHO cell culture

Metabolic Engineering Communications, 2019
Mathematical modelling can provide precious tools for bioprocess simulation, prediction, control and optimization of mammalian cell-based cultures. In this paper we present a novel method to generate kinetic models of such cultures, rendering complex ...
Erika Hagrot, Hildur Æsa Oddsdóttir, Meeri Mäkinen, Anders Forsgren, Véronique Chotteau   +4 more
doaj  

Genomic sequencing and analysis of a Chinese hamster ovary cell line using Illumina sequencing technology

BMC Genomics, 2011
Background Chinese hamster ovary (CHO) cells are among the most widely used hosts for therapeutic protein production. Yet few genomic resources are available to aid in engineering high-producing cell lines. Results High-throughput Illumina sequencing was
Swanberg Jeffrey C, Hammond Stephanie, Kaplarevic Mihailo, Lee Kelvin H   +3 more
doaj   +1 more source

Rapid Identification of Chinese Hamster Ovary Cell Apoptosis and Its Potential Role in Process Robustness Assessment. [PDF]

Bioengineering (Basel), 2023
Xiao S, Li Q, Jiang J, Huo C, Chen H, Guo M.   +5 more
europepmc   +1 more source

Online deployment of an O-PLS model for dielectric spectroscopy-based inline monitoring of viable cell concentrations in Chinese hamster ovary cell perfusion cultivations. [PDF]

Eng Life Sci, 2023
Lemke J, Söldner R, Austerjost J.
europepmc   +1 more source

Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers

Metabolic Engineering Communications, 2019
Biopharmaceutical industrial processes are based on high yielding stable recombinant Chinese Hamster Ovary (CHO) cells that express monoclonal antibodies.
Cyrielle Calmels, Solène Arnoult, Bassem Ben Yahia, Laetitia Malphettes, Mikael Rørdam Andersen   +4 more
doaj  

Dynamics of Amino Acid Metabolism, Gene Expression, and Circulomics in a Recombinant Chinese Hamster Ovary Cell Line Adapted to Moderate and High Levels of Extracellular Lactate. [PDF]

Genes (Basel), 2023
Chitwood DG, Uy L, Fu W, Klaubert SR, Harcum SW, Saski CA.   +5 more
europepmc   +1 more source

Bridging Time Scales in Cellular Decision Making with a Stochastic Bistable Switch [PDF]

arXiv, 2010
Cellular transformations which involve a significant phenotypical change of the cell's state use bistable biochemical switches as underlying decision systems. In this work, we aim at linking cellular decisions taking place on a time scale of years to decades with the biochemical dynamics in signal transduction and gene regulation, occuring on a time ...
arxiv  

THE EFFECT OF CELL-TO-CELL CONTACT ON THE SURFACE MORPHOLOGY OF CHINESE HAMSTER OVARY CELLS [PDF]

, 1973
Robert W. Rubin, Leighton P. Everhart
openalex   +1 more source