Results 71 to 80 of about 1,103,019 (210)
Abstract Purpose Breast cancer is a neoplastic disease with high prevalence among women. Radiotherapy is one of the principal treatment modalities for this disease, but it poses significant challenges. This study aimed to compare and evaluate the technical and dosimetric performance of conventional C‐arm linac systems and a new design, Halcyon, in the ...
Mustafa Çağlar+8 more
wiley +1 more source
Abstract Purpose An evaluation of the accuracy, safety, and efficiency of the Halcyon ring delivery system (RDS) for stereotactic radiosurgery (SRS) treatment to relatively small (1–3 cm) brain lesions. Methods After completing the extensive in‐house quality assurance checks including Winston–Lutz test and independent dose verification via MD Anderson ...
Kate Hazelwood+5 more
wiley +1 more source
Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes
Abstract Objective Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome‐wide association studies (GWAS) for impact on cerebrospinal fluid (CSF) proteins reflecting lysosomal function.
Hanwen Zhang+16 more
wiley +1 more source
An MRI assessment of mechanisms underlying lesion growth and shrinkage in multiple sclerosis
By applying the tensor model, we analysed lesion orientation and the directionality of lesion expansion/contraction in multiple sclerosis. Each lesion is summarized as an ellipsoid, and the tensor model is applied to calculate lesion anisotropy. From the top to the bottom white matter atlas, surface‐in gradient segmentation and venous atlas used in the
Ermelinda De Meo+9 more
wiley +1 more source
FGF14 GAA Intronic Expansion in Unsolved Adult‐Onset Ataxia in the Care4Rare Canada Consortium
ABSTRACT Background and Objectives Spinocerebellar ataxias (SCA) represent a clinically and genetically heterogeneous group of progressive neurodegenerative diseases with prominent cerebellar atrophy. Recently, a novel pathogenic repeat expansion in intron 1 of FGF14 was identified, causing adult‐onset SCA (SCA27B). We aimed to determine the proportion
Alexanne Cuillerier+20 more
wiley +1 more source
Objective Despite knowledge that health outcomes vary according to patient characteristics, identity, and geography, including underrepresented populations in arthritis research remains a challenge. We conducted interviews to explore how researchers in arthritis have used equity, diversity, and inclusion (EDI) principles to inform their research ...
Megan M. Thomas+8 more
wiley +1 more source
On Chip-Firing on Undirected Binary Trees [PDF]
Chip-firing is a combinatorial game played on an undirected graph in which we place chips on vertices. We study chip-firing on an infinite binary tree in which we add a self-loop to the root to ensure each vertex has degree 3. A vertex can fire if the number of chips placed on it is at least its degree. In our case, a vertex can fire if it has at least
arxiv
In this article, the establishment and characterization of a self‐assembled 3D BBB spheroid model using human induced pluripotent stem cell (hiPSC)‐derived and primary cells is reported. Spheroids demonstrate in‐vivo like tight junction ultrastructure and, in comparison to 2D mono‐cultures, higher transcript expression of BBB specific genes.
Sanjana Mathew‐Schmitt+10 more
wiley +1 more source
Chip Firing on Directed $k$-ary Trees [PDF]
Chip-firing is a combinatorial game played on a graph in which we place and disperse chips on vertices until a stable state is reached. We study a chip-firing variant played on an infinite rooted directed $k$-ary tree, where we place $k^\ell$ chips on the root for some positive integer $\ell$, and we say a vertex $v$ can fire if it has at least $k ...
arxiv