Results 71 to 80 of about 5,795,971 (345)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Comparative analysis of process parameters in wear properties of coated and uncoated tool inserts during machining of Hastelloy C-276 [PDF]

FME Transactions, 2020
Machining is the most significant process for any manufacturing company to improve the quality of the finished component. The objective of this article is to analyse the process performance of Hastelloy C-276 using PVD (Physical Vapour Deposition) coated,
Kiran Bandaru, Nagaraju Dega
doaj  

Modelling of material cutting with a material microstructure-level (MML) model [PDF]

, 2013
In this research work a material microstructure-level cutting model (MML cutting model) is presented. The crystal plasticity theory is adopted for modeling the cutting of the titanium alloy Ti–6Al–4V in orthogonal case.
Mabrouki, Tarek, Nelias, Daniel, Yancheng, Zhang   +2 more
core  

Controlling the type and the form of chip when machining steel [PDF]

, 2016
The type of the chip produced in the process of machining influences many factors of production process. Controlling the type of chip when cutting metals is important for producing swarf chips and for easing its utilization as well as for protecting the ...
Arkhipova, D. A., Gruby, S. V., Lasukov, Aleksandr Aleksandrovich, Nekrasov, R. Yu., Politsinsky, Evgeny Valerievich   +4 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

SIMULATING MACHINING OF CONTINUOUSLY VARIABLE TRANSMISSION PULLEYS IN COMPLEX BLADE TOOL TRAJECTORY IN ANSYS SOFTWARE PACKAGE

Модели, системы, сети в экономике, технике, природе и обществе
Background. At the stage of developing the technological process of turning a part, it is important to identify the processes that occur as a result of the impact of the tool on the workpiece.
A.A. Generalova, A.A. Nikulin, D.S. Bychkov   +2 more
doaj   +1 more source

Experimental and Statistical Investigation of Surface Roughness in Turning of AISI 4140 Steel

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2019
In this study, AISI 4140 temperingsteel with 48 HRc hardness was machined on CNC lathe with different cuttingparameters and cooling environment. The Taguchi L9 test design wasdeveloped based on the three-level cutting speed, feed, chip depth and ...
Harun Akkuş
doaj   +1 more source

Indirect monitoring method of tool wear using the analysis of cutting force during dry machining of Ti alloys [PDF]

, 2017
In recent decades, optimize tool life is in constant evolution so many researchers have focused to analysis the tool wear by indirect monitoring (e.g. acoustic emission, cutting forces, vibrations) that plays a significant role in control and improvement
Marcos, Mariano, Sanchez, Yezika, Sevilla-Hurtado, Lorenzo, Trujillo, Francisco Javier   +3 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

The Simulation Analysis of Cutting Characteristics and Chip Formation Mechanism in Gear Skiving

Applied Sciences
Gear skiving is an efficient and high-precision gear processing method, particularly advantageous for internal gears and coupling gears. However, the main limitation of its application is the rapid wear of skiving tools.
Run Mao, Pei Tang, Yudong Zhang, Le Wang, Zheng Guo, Shimin Mao   +5 more
doaj   +1 more source