Results 81 to 90 of about 5,795,971 (345)

Establish Using FEM Method of Constitutive Model for Chip Formation in the Cutting Process of Gray Cast Iron

Metals, 2019
The constitutive equation of mechanics, namely the stress−strain model of the material, is used to describe the mathematical expression of the mechanical properties of the material (stress−strain−intensity−time relationship).
Lihui Tu, Weimin Shi
doaj   +1 more source

Анализ термодинамических неустойчивостей при стружкообразовании [PDF]

, 2014
Представлен подход к анализу термодинамических неустойчивостей, имеющих место при стружкообразовании в процессах резания. Выявлено два вида неустойчивостей – неустойчивый узел и неустойчивое седло.
Клименко, С. А., Хейфец, М. Л.   +1 more
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Observation of chip-producing behavior in ultraprecision diamond cutting of additively manufactured Alloy 718 utilizing ultrasonic elliptical vibration

Journal of Advanced Mechanical Design, Systems, and Manufacturing
The demand for Ni-based alloys, particularly Alloy 718, is increasing in the gas turbine industry due to their high-temperature resistance and chemical stability.
Shunsaku KAWASAKI, Norio YAMASHITA, Shinya MORITA, Hideo YOKOTA   +3 more
doaj   +1 more source

Micro Ball End Milling of Titanium Alloy Using a Tool with a Microstructured Rake Face

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
Many parts and structures for aerospace engineering, marine engineering, bioengineering, etc. are made of titanium alloy because of its excellent physical, chemical, biological and mechanical properties.
Toshiyuki OBIKAWA, Bunji KANI
doaj   +1 more source

Modelling High Speed Machining with the SPH Method [PDF]

, 2008
The purpose of this work is to evaluate the use of the Smoothed Particle Hydrodynamics (SPH) method within the framework of high speed cutting modelling. First, a 2D SPH based model is carried out using the LS-DYNA® software.
Chieragatti, Rémy, Espinosa, Christine, Lacome, Jean-Luc, Limido, Jérôme, Mabru, Catherine, Salaün, Michel   +5 more
core  

Determination of micro-scale plastic strain caused by orthogonal cutting [PDF]

, 2008
An electron beam lithography technique has been used to produce microgrids in order to measure local plastic strains, induced during an orthogonal cutting process, at the microscopic scale in the shear zone and under the machined surface. Microgrids with
Allais, Altintas, Beynon, Bitans, C. Pinna, Childs, Delaire, H. Ghadbeigi, Hernandez Castillo, Iwata, J.R. Yates, Jeelani, Jeelani, Karimi, Koshelev, Kurt, Lee, Lin, Madhavan, Mamalis, Merchant, Ng, Obata, Palmer, Pinna, S.R. Bradbury, Sadat, Sadat, Shet, Shih, Sun, Zhang   +31 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Cutting Force Prediction in Drilling of Titanium Alloy

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
Cutting force in drilling of Ti-6Al-4V is studied with simulation based on a predictive model. In the force model, three-dimensional chip flow is made by piling up the orthogonal cuttings in the planes containing the cutting velocities and the chip flow ...
Shoichi TAMURA, Takashi MATSUMURA, Pedro J. ARRAZOLA   +2 more
doaj   +1 more source

Fabrication of three-dimensional microdisk resonators in calcium fluoride by femtosecond laser micromachining

, 2014
We report on fabrication of on-chip calcium fluoride (CaF2) microdisk resonators using water-assisted femtosecond laser micromachining. Focused ion beam (FIB) milling is used to create ultra-smooth sidewalls.
Cheng, Ya, Fang, Wei, He, Fei, Lin, Jintian, Song, Jiangxin, Tang, Jialei, Wang, Nengwen, Xu, Yingxin   +7 more
core   +1 more source