Results 71 to 80 of about 135,263 (269)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Deep Learning Study on Memory IC Package Warpage Using Deep Neural Network and Finite Element Simulation

Chips
In recent years, many electronic device industries have shown interest in using artificial intelligence (AI) to quickly estimate package warpage. Machine learning is one of the AI techniques which will give an express prediction on package warpage with ...
Sunil Kumar Panigrahy, Fa Xing Che, Yeow Chon Ong, Hong Wan Ng, Gokul Kumar   +4 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Highly Versatile Photonic Integration Platform on an Indium Phosphide Membrane

Chips
The fast-maturing photonic integration technology is calling for a versatile platform that supports both active and passive functions as well as high scalability through component miniaturization.
Sander Reniers, Yi Wang, Salim Abdi, Jasper de Graaf, Aleksandr Zozulia, Kevin Williams, Yuqing Jiao   +6 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A Survey on Computing-in-Memory (CiM) and Emerging Nonvolatile Memory (NVM) Simulators

Chips
Modern computer applications have become highly data-intensive, giving rise to an increase in data traffic between the processor and memory units. Computing-in-Memory (CiM) has shown great promise as a solution to this aptly named von Neumann bottleneck ...
John Taylor Maurer, Ahmed Mamdouh Mohamed Ahmed, Parsa Khorrami, Sabrina Hassan Moon, Dayane Alfenas Reis   +4 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Design Analysis of a Modified Current-Reuse Low-Power Wideband Single-Ended CMOS LNA

Chips
This paper presents the design analysis of a low-power wideband single-ended CMOS low-noise amplifier (LNA). The proposed topology is based on a modified current- reuse circuit, in which two-stage common-source (CS) amplifiers consume the same DC current
Farshad Shirani Bidabadi, Mahalingam Nagarajan, Thangarasu Bharatha Kumar, Yeo Kiat Seng   +3 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Atomic‐Scale Mechanisms of Multi‐Resistance States in HfOx‐Based RRAM: Evolution of Atomic Electric Fields and Oxygen Vacancies

Advanced Science
The stability of multilevel resistive switching in HfOx‐based RRAM is crucial for enhancing matrix‐vector multiplication efficiency in computing‐in‐memory architectures, yet precise control over conductive filament formation is limited by an incomplete ...
Wen Sun, Yuyan Wang, Ruofei Hu, Yuyao Lu, Jun Xu, Xinyi Li, Bin Gao, He Qian, Jianshi Tang, Huaqiang Wu   +9 more
doaj   +1 more source