Results 71 to 80 of about 36,118 (224)

Chemistry and Biology of Streptogramin A Antibiotics [PDF]

, 2007
The streptogramin A antibiotics have proven to be highly active against Gram positive bacteria, particularly methicillin-resistant Staphylococcus aureus. Members of this group of compounds are characterized by a 23-membered macrocycles containing polyene,
Ahmed, Fahim, Donaldson, William
core   +1 more source

Cooperative catalysis by silica-supported organic functional groups [PDF]

, 2008
Hybrid inorganic–organic materials comprising organic functional groups tethered from silica surfaces are versatile, heterogeneous catalysts. Recent advances have led to the preparation of silica materials containing multiple, different functional groups
Davis, Mark E., Margelefsky, Eric L., Zeidan, Ryan K.   +2 more
core   +1 more source

Laboratory evolution of an alcohol dehydrogenase towards enantioselective reduction of difficult-to-reduce ketones

Bioresources and Bioprocessing, 2019
Background A thermostable alcohol dehydrogenase from Thermoanaerobacter brockii (TbSADH) has been repurposed to perform asymmetric reduction of a series of prochiral ketones with the formation of enantio-pure secondary alcohols, which are crucial chiral ...
Ge Qu, Beibei Liu, Yingying Jiang, Yao Nie, Huilei Yu, Zhoutong Sun   +5 more
doaj   +1 more source

Homochirality and the need of energy

, 2009
The mechanisms for explaining how a stable asymmetric chemical system can be formed from a symmetric chemical system, in the absence of any asymmetric influence other than statistical fluctuations, have been developed during the last decades, focusing on
A Ben-Naim, A Brandenburg, A Brandenburg, A Giaquinta, A Pérez-Madrid, Axel Brandenburg, C Huber, C Viedma, C Viedma, D Blackmond, D Hochberg, D Kondepudi, D Kondepudi, DG Blackmond, DG Blackmond, DG Blackmond, DK Kondepudi, DK Kondepudi, F Faglioni, F Kipping, FC Frank, G Lente, GD Cody, J Crusats, J Crusats, J Crusats, JD Farmer, JL Bada, JL Bada, JM Cruz, JM McBride, JS Siegel, K Asakura, K Asakura, K Asakura, K Soai, M Avalos, M Bellac Le, M Eigen, M Gleiser, M Gleiser, M Lahav, M Mauksch, M Mauksch, M Mauksch, N Wagner, O Abramov, P Curie, PM Masters, PW Voorhees, R Pagni, R Plasson, R Plasson, R Plasson, R Plasson, R Plasson, Raphaël Plasson, RH Swendsen, S Chandrasekhar, SF Mason, SK Lin, SK Lin, T Gánti, T Hitz, T Multamäki, TL Hill, WA Bonner, WL Noorduin, WL Noorduin, Y Saito, Y Saito   +70 more
core   +1 more source

Boranes in Organic Chemistry 1. О±-Carbonylalkyl- and ОІ-Oxyalkylboranes in Organic Synthesis

Eurasian Chemico-Technological Journal, 2002
This review is devoted to the synthesis of a-carbonylalkyl- and ОІ-hydroxy-alkyl boranes and their use in organic synthesis. a-Carbonyl-alkylboranes include several heteroatomic compounds, in particular, [1.2.3]-diazaborinines, uracyl boronic acids, and [
V.M. Dembitsky, G.A. Tolstikov, M. Srebnik   +2 more
doaj   +1 more source

Organocatalytic stereodivergent synthesis of β,β-disubstituted-α-aminoacids [PDF]

, 2017
In this work, we present an organocatalytic stereodivergent synthesis of β,β-disubstituted-α-aminoacids using arylidene azlactones as starting materials.
Martinelli, Ada
core  

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents. [PDF]

, 2008
Following our previous research on anti-inflammatory drugs (NSAIDs), we report here the synthesis of chiral 1,5-diarylpyrroles derivatives that were characterized for their in vitro inhibitory effects toward cyclooxygenase (COX) isozymes.
ANZELLOTTI P., ANZINI M., BIAVA M., BOTTA M., CIRILLI R., FERRETTI R., FORLI ., GALLINELLA B., GHELARDINI C., GIORDANI A., LA TORRE F., MAKOVEC F., MANETTI F., NORCINI M., PATRIGNANI P., PERGOLA C., POCE G., PORRETTA G. C., ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, SUPINO S.   +20 more
core   +1 more source

Engineering an Artificial Pathway to Improve the Bioconversion of Lysine into Chiral Amino Alcohol 2-Hydroxycadaverine Using a Semi-Rational Design

Fermentation
Amino alcohols are important compounds that are widely used in the polymer and pharmaceutical industry, particularly when used as chiral scaffolds in organic synthesis.
Jie Cheng, Shujian Xiao, Qing Luo, Bangxu Wang, Rumei Zeng, Liming Zhao, Jiamin Zhang   +6 more
doaj   +1 more source

Chiral primary amino alcohol organobase catalyst for the asymmetric Diels-Alder reaction of anthrones with maleimides [PDF]

, 2015
Simple chiral TES-amino alcohol organocatalysts containing a bulkysilyl [triethylsilyl: TES] group on oxygen atom at γ-position were designed andsynthesized as new organocatalysts for the enantioselective Diels-Alder (DA) reactionof anthrones with ...
KOHARI Yoshihito, KUMAGAI Jun, KWON Eunsang, NAKANO Hiroto, OKUYAMA Yuko, OTSUKI Teppei, SEKI Chigusa, TAKESHITA Mitsuhiro, TOKIWA Michio, UMMAREDDY Venkata Subba Reddy, UWAI Koji   +10 more
core   +2 more sources

Recent Advances in Homogeneous Metal-Catalyzed Aerobic C–H Oxidation of Benzylic Compounds [PDF]

, 2018
Csp(3)-H oxidation of benzylic methylene compounds is an established strategy for the synthesis of aromatic ketones, esters, and amides. The need for more sustainable oxidizers has encouraged researchers to explore the use of molecular oxygen.
Domínguez Pérez, Pilar Esther, Herrero Corral, María Teresa, San Martín Faces, Raúl, Urgoitia Gabikaetxebarria, Garazi   +3 more
core   +3 more sources