Results 1 to 10 of about 32,089 (279)

Supramolecular Chiral Nanozymes with High and Switchable Enantioselectivity

Small Structures, 2023
Understanding and manipulation of catalytic enantioselectivity have emerged as a paramount challenge for decades. Inspired by nature, nanozymes with enantioselectivity have been designed.
Chu Wang, Ganyin Yuan, Chao Wang, Xiaohuan Sun, Pengyuan Hang, Zheng Xi, Jie Han, Rong Guo   +7 more
doaj   +2 more sources

Engineering the Enantioselectivity of Yeast Old Yellow Enzyme OYE2y in Asymmetric Reduction of (E/Z)-Citral to (R)-Citronellal

Molecules, 2019
The members of the Old Yellow Enzyme (OYE) family are capable of catalyzing the asymmetric reduction of (E/Z)-citral to (R)-citronellal—a key intermediate in the synthesis of L-menthol. The applications of OYE-mediated biotransformation are usually
Xiangxian Ying, Shihua Yu, Meijuan Huang, Ran Wei, Shumin Meng, Feng Cheng, Meilan Yu, Meirong Ying, Man Zhao, Zhao Wang   +9 more
doaj   +2 more sources

Biomolecular Chemical Simulations on Enantioselectivity and Reactivity of Lipase Enzymes to Azulene Derivatives

Natural Product Communications, 2022
Biomolecular chemical simulations have recently become a useful research method in the fields of organic chemistry and bioscience. In the last few years, we have been focusing on the biomolecular computational simulation on lipase enzyme and ligand ...
Yoichiro Yagi, Takatomo Kimura, Makoto Kamezawa   +2 more
doaj   +1 more source

Comprehensive Analysis of a Yeast Lipase Family in the Yarrowia Clade. [PDF]

PLoS ONE, 2015
Lipases are currently the subject of intensive studies due to their large range of industrial applications. The Lip2p lipase from the yeast Yarrowia lipolytica (YlLIP2) was recently shown to be a good candidate for different biotechnological applications.
Muchalin Meunchan, Stéphanie Michely, Hugo Devillers, Jean-Marc Nicaud, Alain Marty, Cécile Neuvéglise   +5 more
doaj   +1 more source

Directed evolution of lipase A from Bacillus subtilis for the preparation of enantiocomplementary sec-alcohols

Green Synthesis and Catalysis, 2021
Biocatalysts with tailor-made or controllable stereoselectivity are valuable and highly desired in the precision synthesis of chiral compounds. Most lipases display excellent (R)-enantioselectivity for various sec-alcohols.
Danyang Li, Xiaoyang Chen, Zhichun Chen, Xianfu Lin, Jian Xu, Qi Wu   +5 more
doaj   +1 more source

Computational Study of Mechanism and Enantioselectivity of Imine Reductase from Amycolatopsis orientalis

ChemistryOpen, 2022
Imine reductases (IREDs) are NADPH‐dependent enzymes (NADPH=nicotinamide adenine dinucleotide phosphate) that catalyze the reduction of imines to amines.
Dr. Mario Prejanò, Prof. Dr. Xiang Sheng, Prof. Dr. Fahmi Himo   +2 more
doaj   +1 more source

Enantioselectivity of discretized helical supramolecule consisting of achiral cobalt phthalocyanines via chiral-induced spin selectivity effect

Nature Communications, 2023
Enantioselectivity of helical aggregation is conventionally directed either by its homochiral ingredients or by introduction of chiral catalysis. The fundamental question, then, is whether helical aggregation that consists only of achiral components can ...
Hiroki Aizawa, Takuro Sato, Saori Maki-Yonekura, Koji Yonekura, Kiyofumi Takaba, Tasuku Hamaguchi, Taketoshi Minato, Hiroshi M. Yamamoto   +7 more
doaj   +1 more source

Engineering of Yeast Old Yellow Enzyme OYE3 Enables Its Capability Discriminating of (E)-Citral and (Z)-Citral

Molecules, 2021
The importance of yeast old yellow enzymes is increasingly recognized for direct asymmetric reduction of (E/Z)-citral to (R)-citronellal. As one of the most performing old yellow enzymes, the enzyme OYE3 from Saccharomyces cerevisiae S288C exhibited ...
Tairan Wang, Ran Wei, Yingting Feng, Lijun Jin, Yunpeng Jia, Duxia Yang, Zuonan Liang, Mengge Han, Xia Li, Chenze Lu, Xiangxian Ying   +10 more
doaj   +1 more source

Redesign of a short-chain dehydrogenase/reductase for asymmetric synthesis of ethyl (R)-2-hydroxy-4-phenylbutanoate based on per-residue free energy decomposition and sequence conservatism analysis

Green Synthesis and Catalysis, 2020
As an important building block for the synthesis of angiotensin-converting enzyme inhibitors, ethyl (R)-2-hydroxyl-4-phenylbutanoate [(R)-HPBE] has attracted increasing attention.
Bingmei Su, Lian Xu, Xinqi Xu, Lichao Wang, Aipeng Li, Juan Lin, Lidan Ye, Hongwei Yu   +7 more
doaj   +1 more source

Enantioselectivity-Evaluation of Chiral Copper(II) Complexes Coordinated by Novel Chiral Tetradentate Ligands for Free Amino Acids by Mass Spectrometry Coupled With the Isotopically Labeled Enantiomer Method

Frontiers in Chemistry, 2020
A series of copper(II) complexes with chiral tetradentate ligands, N,N′-ethylene- bis(S-amino acid methyl amide or methyl ester) prepared from S-alanine, S-phenylalanine, S-valine or S-proline, was generated in methanol.
Takashi Nakakoji, Kaori Yoshino, Kazuki Izutsu, Hirofumi Sato, Hiroyuki Miyake, Eiko Mieda, Satoshi Shinoda, Hiroshi Tsukube, Hideya Kawasaki, Ryuichi Arakawa, Daisuke Ono, Motohiro Shizuma   +11 more
doaj   +1 more source