Results 11 to 20 of about 42,802 (288)

Engineering the Enantioselectivity of Yeast Old Yellow Enzyme OYE2y in Asymmetric Reduction of (E/Z)-Citral to (R)-Citronellal

Molecules, 2019
The members of the Old Yellow Enzyme (OYE) family are capable of catalyzing the asymmetric reduction of (E/Z)-citral to (R)-citronellal—a key intermediate in the synthesis of L-menthol. The applications of OYE-mediated biotransformation are usually
Xiangxian Ying, Shihua Yu, Meijuan Huang, Ran Wei, Shumin Meng, Feng Cheng, Meilan Yu, Meirong Ying, Man Zhao, Zhao Wang   +9 more
doaj   +1 more source

Redesign of a short-chain dehydrogenase/reductase for asymmetric synthesis of ethyl (R)-2-hydroxy-4-phenylbutanoate based on per-residue free energy decomposition and sequence conservatism analysis

Green Synthesis and Catalysis, 2020
As an important building block for the synthesis of angiotensin-converting enzyme inhibitors, ethyl (R)-2-hydroxyl-4-phenylbutanoate [(R)-HPBE] has attracted increasing attention.
Bingmei Su, Lian Xu, Xinqi Xu, Lichao Wang, Aipeng Li, Juan Lin, Lidan Ye, Hongwei Yu   +7 more
doaj   +1 more source

Phosphoramidite Gold(I)-Catalyzed Diastereo- and Enantioselective Synthesis of 3,4-Substituted Pyrrolidines [PDF]

, 2011
In this article the utility of phosphoramidite ligands in enantioselective AuI catalysis was explored in the development of highly diastereo- and enantioselective AuI-catalyzed cycloadditions of allenenes.
Benitez, Diego, Goddard, William A., III, González, Ana Z., Tkatchouk, Ekaterina, Toste, F. Dean   +4 more
core   +3 more sources

Enantioselectivity-Evaluation of Chiral Copper(II) Complexes Coordinated by Novel Chiral Tetradentate Ligands for Free Amino Acids by Mass Spectrometry Coupled With the Isotopically Labeled Enantiomer Method

Frontiers in Chemistry, 2020
A series of copper(II) complexes with chiral tetradentate ligands, N,N′-ethylene- bis(S-amino acid methyl amide or methyl ester) prepared from S-alanine, S-phenylalanine, S-valine or S-proline, was generated in methanol.
Takashi Nakakoji, Kaori Yoshino, Kazuki Izutsu, Hirofumi Sato, Hiroyuki Miyake, Eiko Mieda, Satoshi Shinoda, Hiroshi Tsukube, Hideya Kawasaki, Ryuichi Arakawa, Daisuke Ono, Motohiro Shizuma   +11 more
doaj   +1 more source

Ferrocene-derived P,N ligands : synthesis and application in enantioselective catalysis [PDF]

, 2013
Due to their unique steric and electronic properties, air-stability and modular structure, chiral hybrid P,N-ferrocenyl ligands play a prominent role in the field of asymmetric catalysis.
Noël, Timothy, Van der Eycken, Johan
core   +1 more source

Synthesis of Solution-Phase Phosphoramidite and Phosphite Ligand Libraries and Their In Situ Screening in the Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids [PDF]

, 2007
Herein, we report the automated parallel synthesis of solution-phase libraries of phosphoramidite ligands for the development of enantioselective catalysts.
Feringa, Ben L.,, Jagt, Richard B.C.,, Minnaard, Adriaan J.,, Schudde, Ebe P.,, Toullec, Patrick Y.,, Vries, Johannes G. de,   +5 more
core   +1 more source

Organocatalyzed Enantioselective Fluorocyclizations

Angewandte Chemie International Edition, 2011
Enantioenriched fluorinated heterocycles can be prepared through fluorocyclizations of prochiral indoles (see scheme; Ts=tosyl, Bn=benzyl, Boc=tert-butoxycarbonyl). More than twenty examples for this cascade fluorination-cyclization, which is catalyzed by cinchona alkaloids and employs N-fluorobenzenesulfonimide as the electrophilic fluorine source ...
Lozano, O, Blessley, G, Martinez del Campo, T, Thompson, A, Giuffredi, G, Bettati, M, Walker, M, Borman, R, Gouverneur, V   +8 more
openaire   +2 more sources

Flexible Enantioselectivity of Tryptophanase Attributable to Benzene Ring in Heterocyclic Moiety of D-Tryptophan

Life, 2012
The invariance principle of enzyme enantioselectivity must be absolute because it is absolutely essential to the homochiral biological world. Most enzymes are strictly enantioselective, and tryptophanase is one of the enzymes with extreme absolute ...
Akihiko Shimada, Haruka Ozaki
doaj   +1 more source

Asymmetric additions to dienes catalysed by a dithiophosphoric acid. [PDF]

, 2011
Chiral Brønsted acids (proton donors) have been shown to facilitate a broad range of asymmetric chemical transformations under catalytic conditions without requiring additional toxic or expensive metals.
Hamilton, Gregory, Rauniyar, Vivek, Shapiro, Nathan, TOSTE, F. Dean, Wu, Jeffrey   +4 more
core   +2 more sources

Enantioselective Synthesis of 2,2-Disubstituted Terminal Epoxides via Catalytic Asymmetric Corey-Chaykovsky Epoxidation of Ketones

Molecules, 2012
Catalytic asymmetric Corey-Chaykovsky epoxidation of various ketones with dimethyloxosulfonium methylide using a heterobimetallic La-Li3-BINOL complex (LLB) is described.
Shigeki Matsunaga, Masakatsu Shibasaki, Toshihiko Sone, Akitake Yamaguchi   +3 more
doaj   +1 more source