Results 21 to 30 of about 12,531 (256)
Carbohydrate-Based Azacrown Ethers in Asymmetric Syntheses
Chemistry, 2021 Carbohydrate-based crown ethers represent a special group of chiral phase transfer catalysts. Several derivatives of these macrocycles have been synthesized in our research group.
István Orbán, Péter Bakó, Zsolt Rapi
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Molecules, 2023 Synthetic cathinones, such as 3,4-methylenedioxypyrovalerone (MDPV), are widely abused due to their psychostimulant effects. As they are chiral molecules, studies of their stereochemical stability (racemization can occur in certain temperatures and ...
Ana Sofia Almeida +5 more
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Enhanced Production of (S)-2-arylpropionic Acids by Protein Engineering and Whole-Cell Catalysis
Frontiers in Bioengineering and Biotechnology, 2021 Esterases are important biocatalysts for chemical synthesis. Several bHSL family esterases have been used to prepare (S)-2-arylpropionic acids with stronger anti-inflammatory effects via kinetic resolution.
Xiaolong Liu +3 more
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Enantioselective Hydrocarbamoylation of Alkenes
Angewandte Chemie International Edition, 2022 AbstractThe asymmetric hydroaminocarbonylation of olefins represents a straightforward approach for the synthesis of enantioenriched amides, but is hampered by the necessity to employ CO gas, often at elevated pressures. We herein describe, as an alternative, an enantioselective hydrocarbamoylation of alkenes leveraging dual copper hydride and ...
Sheng Feng +2 more
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Enantioselective Desymmetrization of FTY720
Chemical and Pharmaceutical Bulletin, 2014 A method for enantioselective desymmetrization of N-Ac and N-Boc-FTY720 by nonenzymatic asymmetric acylation was developed. Effective enantioselective monobenzoylation using benzoyl chloride in the presence of the tetraphenylbisoxazoline (L2)-CuCl2 complex gave the desired products 3a and 3b in 52-62% yield with 64% ee.
Hikawa, Hidemasa +5 more
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Enantioselective Synthesis of (−)-Acetylapoaranotin
Organic Letters, 2017 The first enantioselective total synthesis of the epipolythiodiketopiperazine (ETP) natural product (-)-acetylapoaranotin (3) is reported. The concise synthesis was enabled by an eight-step synthesis of a key cyclohexadienol-containing amino ester building block.
Haoxuan Wang +5 more
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Evolving P450pyr Monooxygenase for Regio- and Stereoselective Hydroxylations
CHIMIA, 2015 P450pyr monooxygenase from Sphingomonas sp. HXN-200 catalysed the regio- and stereoselective hydroxylation at a non-activated carbon atom, a useful but challenging reaction in classic chemistry, with unique substrate specificity for a number of ...
Yi Yang, Zhi Li
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Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Nature CommunicationsCarboxylesterases serve as potent biocatalysts in the enantioselective synthesis of chiral carboxylic acids and esters. However, naturally occurring carboxylesterases exhibit limited enantioselectivity, particularly toward ethyl 3-cyclohexene-1 ...
Zhe Dou +8 more
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Efficient Improving the Activity and Enantioselectivity of Candida rugosa Lipase for the Resolution of Naproxen by Enzyme Immobilization on MCM-41 Mesoporous Molecular Sieve [PDF]
International Journal Bioautomation, 2015 Lipase from Candida rogusa was immobilized on MCM-41 mesoporous molecular sieves in a trapped aqueous-organic biphase system for the resolution of racemic naproxen methyl ester.
Ying Chen, Yi Xu, Xiao-mei Wu
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