Results 91 to 100 of about 2,895 (193)

Enantioselective Determination of Upadacitinib in Pharmaceutical Formulations Using Reversed‐Phase Chiral Liquid Chromatography

Journal of Separation Science, Volume 49, Issue 9, September 2026.
A reversed‐phase chiral HPLC method was developed for the enantioselective separation and quantification of upadacitinib using a Box‐Behnken design. The validated method was successfully applied to the quantification of upadacitinib in a commercial tablet formulation, and its environmental impact and practicality were evaluated using various assessment
Sakine Atila Karaca, Sona Aliyeva, Duygu Yeniceli   +2 more
wiley   +1 more source

Thermal Curing-Enhanced Circularly Polarized Phosphorescence

Molecules
Developing circularly polarized phosphorescence (CPP) materials integrating long-afterglow room-temperature phosphorescence (RTP) and chiral optical properties is highly attractive but challenging.
Shouchang Jiao, Rui Du, Jingcheng Wang, Hanlin Ou   +3 more
doaj   +1 more source

A Review on Green Synthetic Approaches in the Development of Quinoline Analogues

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This review highlights recent advances in environmentally friendly approaches, including metal‐free systems, solvent‐free approaches, microwave, and ultrasonic‐assisted techniques, organo‐ and biocatalysis, ionic liquids, nanoparticle catalysis, electrochemical, and photocatalytic strategies for the synthesis of quinoline scaffolds.
Demis Zelelew, Ajay Bissessur, Parvesh Singh, Hogantharanni Govender   +3 more
wiley   +1 more source

Safety and efficacy of a feed additive consisting of l‐threonine produced using Corynebacterium glutamicum KCCM 80367 for all animal species (CJ Europe GmbH)

EFSA Journal, Volume 24, Issue 9, September 2026.
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l‐threonine produced by fermentation using the genetically modified strain of Corynebacterium glutamicum, KCCM 80367, as a nutritional additive in feed for all animal species and categories.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Giovanna Martelli, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Katerina Theodoridou, Montserrat Anguita, Matteo L. Innocenti, Elisa Pettenati, Joana Revez, Jordi Tarrés‐Call, Joana P. Firmino   +22 more
wiley   +1 more source

Catalytic enantioselective synthesis of azahelicenes via cascade Pictet-Spengler reaction and dehydrogenative aromatization

Nature Communications
The introduction of N-heteroaromatic rings like pyridine and pyrrole into the helicene scaffold can significantly impact the electronic properties, redox potentials and coordination abilities of helicenes, which lead to diverse and intriguing ...
Tianren Qin, Wansen Xie, Xiaoyu Yang
doaj   +1 more source

Endo-Functionalized Cyclic Oligophenylenes: Synthesis and Complexation with a Chiral Phosphoric Acid. [PDF]

ACS Omega, 2022
Ono K, Tanaka Y, Sugimoto K, Kinubari S, Kawai H.   +4 more
europepmc   +1 more source

MATEO: intermolecular α-amidoalkylation theoretical enantioselectivity optimization. Online tool for selection and design of chiral catalysts and products

Journal of Cheminformatics
The enantioselective Brønsted acid-catalyzed α-amidoalkylation reaction is a useful procedure is for the production of new drugs and natural products.
Paula Carracedo-Reboredo, Eider Aranzamendi, Shan He, Sonia Arrasate, Cristian R. Munteanu, Carlos Fernandez-Lozano, Nuria Sotomayor, Esther Lete, Humberto González-Díaz   +8 more
doaj   +1 more source

Data Science Enables the Development of a New Class of Chiral Phosphoric Acid Catalysts. [PDF]

Chem, 2023
Liles JP, Rouget-Virbel C, Wahlman JLH, Rahimoff R, Crawford JM, Medlin A, O'Connor V, Li J, Roytman VA, Toste FD, Sigman MS.   +10 more
europepmc   +1 more source

Dynamic Kinetic Stereoselective Glycosylation via Rh^II and Chiral Phosphoric Acid-Cocatalyzed Carbenoid Insertion to the Anomeric OH Bond for the Synthesis of Glycoconjugates. [PDF]

Angew Chem Int Ed Engl, 2023
Wu J, Jia P, Kuniyil R, Liu P, Tang W.
europepmc   +1 more source

Catalytic Asymmetric Difluoroalkylation Using In Situ Generated Difluoroenol Species as the Privileged Synthon

Advanced Science
A robust and practical difluoroalkylation synthon, α,α‐difluoroenol species, which generated in situ from trifluoromethyl diazo compounds and water in the presence of dirhodium complex, is disclosed.
Xiongda Xie, Shanliang Dong, Kemiao Hong, Jingjing Huang, Xinfang Xu   +4 more
doaj   +1 more source