Results 81 to 90 of about 2,895 (193)

Molybdenum‐Catalyzed Asymmetric Amination of α‐Hydroxy Esters: Synthesis of α‐Amino Acids

Advanced Science
Unnatural α‐amino acids are found in a wide variety of bioactive compounds ranging from proteins to pharmaceutical agents to materials science. As a result, the investigation of efficient and simple methods for their synthesis is a major purpose in ...
Shahida Perveen, Tahir Rahman, Tariq Ali, Lingyun Wang, Junjie Zhang, Ajmal Khan   +5 more
doaj   +1 more source

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

Chirality Fixation of Ag‐Based Nanoclusters via Co‐Crystallization With Ag–P Complexes: Unlocking Circularly Polarized Luminescence

Aggregate, Volume 7, Issue 9, September 2026.
A co‐crystallization method efficiently separates intrinsically chiral metal nanocluster racemates without costly chiral additives. Auxiliary Ag(PPh3)3Cl molecules provide abundant aromatic sites to build dense noncovalent networks and lock stable, single‐handed nanocluster conformations.
Chuanjun Zhou, Xiao Wei, Kaiyang Kuang, Jun Cheng, Sanwen Ni, Jiahao Liu, Wenjun Ma, Hao Li, Shuang Chen, Manzhou Zhu   +9 more
wiley   +1 more source

Machine Learning for Synthetic Organic Chemistry: Methods, Applications, and Best Practices

Angewandte Chemie Novit, Volume 2, Issue 3, September 2026.
Artificial intelligence (AI) and machine learning (ML) are increasingly reshaping experimental chemistry. This review maps the challenges of synthetic organic chemistry to modern digital tools that can help address them. While focusing on the practical application of ML tools in real‐world laboratory settings, we outline prerequisites, emerging ...
Niklas Hölter, Felix Katzenburg, Florian Boser, Frank Glorius   +3 more
wiley   +1 more source

Chemically Regulated STING‐Activating Prodrugs of Deoxyribose Cyclic Dinucleotides Elicit Robust Immune Activation and Durable Antitumor Immunity

Angewandte Chemie, Volume 138, Issue 35, 24 August 2026.
All three diastereoisomers of an esterase‐sensitive phosphotriester dCDN prodrug demonstrate improved activity. The (Rp,Rp) diastereoisomer shows the highest activity with an EC50 of 1.7 nM in STING activation and displays the most pronounced antitumor activity via intravenous administration, significantly suppressing tumor proliferation, extending the
Zhiqiang Xie, Huimin Liu, Yuchen Yang, Xiaohan Sun, Jingwen Wang, Tianxiang Liu, Baifan Wang, Wenrui Qiu, Yiwen Sun, Yuting Bai, Yao Zhang, Dejun Ma, Rong Xiang, Shibo Li, Zhen Xi   +14 more
wiley   +2 more sources

[2 + 2 + 2] Cycloaddition Reactions Using 3d Metal Catalysts: Photo‐ and Electrocatalytic Systems

ChemistryEurope, Volume 4, Issue 9, September 2026.
Turn on the switches: light and electricity reprograming of [2 + 2 + 2] cyclotrimerizations. This perspective maps energy‐tunable 3d metal catalysis that enables the assembly of carbo‐ and heteroaromatics from alkynes and nitriles under mild, sustainable reaction conditions, unveiling the opportunities recently provided by photo‐ and electrocatalysis ...
Benedikt N. Baumann, Marko Hapke
wiley   +1 more source

Hydrazone‐Type Ligands for Asymmetric Catalysis

ChemistryEurope, Volume 4, Issue 9, September 2026.
The introduction of trans 2,5‐disubstituted pyrrolidines is the key design element enabling the excellent stereocontrol exerted by hydrazone‐based N‐ligands in a variety of transition metal‐catalyzed transformations, including Diels–Alder cycloadditions, Suzuki/Hiyama/Negishi cross‐couplings, 1,2‐additions to a variety of imines and hydrazones, and ...
Esteban Matador, Saúl Alberca, Rosario Fernández, David Monge, José M. Lassaletta   +4 more
wiley   +1 more source

Organocatalyzed diastereo- and enantioselective synthesis of N–N atropisomeric isoindolinones bearing central chirality

Nature Communications
Methods for catalytically constructing of N–N axially chiral scaffolds have garnered significant attention since such compounds are widely present in natural products, bioactive molecules, and organic materials.
Xingguang Li, Xin-Ze Wang, Boming Shen, Qian-Yu Chen, Huijing Xiang, Peiyuan Yu, Pei-Nian Liu   +6 more
doaj   +1 more source

Methamphetamine Enantiomers: From Chemical Synthesis to Biological Fate

Chirality, Volume 38, Issue 9, September 2026.
Methamphetamine is an amphetamine‐type stimulant characterized by a single stereogenic center, resulting in two enantiomers, (R)‐(−)‐methamphetamine and (S)‐(+)‐methamphetamine, with distinct biological and pharmacological profiles. These forms exhibit differences in central nervous system activity, metabolism, excretion, and overall physiological ...
Larissa Pires do Espírito Santo, Renato Lúcio de Carvalho, Juliana Almeida Sad, Pedro Henrique Costa dos Santos, Rhaiza Silva Domingues, Gabriele de Azevedo Cardoso, Karine Braga Enes, Gisele Assis Castro Goulart, Maila de Castro Lourenço das Neves, Ângelo de Fátima   +9 more
wiley   +1 more source

Layered π Systems Based on Ferrocenophanes

European Journal of Inorganic Chemistry, Volume 29, Issue 25, 1 September 2026.
Syntheses of a variety of ferrocenophanes and extensions of their π systems are reported. These are performed by Knoevenagel reactions and predominantly lead to syn diastereomers. Eight ferrocenophanes were crystallographically characterized. [1.1]Ferrocenophane was prepared by the literature method along with a small amount of [1.1.1.1]ferrocenophane,
Wing‐Yin Tsang, Holger Butenschön
wiley   +1 more source