Results 61 to 70 of about 10,876 (228)

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

An ATP‐Mediated Antibiotic β‐Peptide Nanofiber That Kills Multidrug‐Resistant Bacteria via a Multistage Mechanism

Advanced Science, EarlyView.
The 3K‐AP system forms infinite supramolecular fibrils that undergo controlled degradation into shorter fragments upon enzymatic hydrolysis. Multitechnique imaging reveals a stepwise bacteriolytic mechanism involving bacterial entrapment, disassembly into lethal constructs, and associated extracellular vesicle release, highlighting the dynamic ...
Sohini Chakraborty, Kamal el Battioui, Dániel Molnár, Bálint Jezsó, Lejla Daruka, Tasvilla Sonallya, Tünde Juhász, Rita Hirmondó, Imola Cs. Szigyártó, Loránd Románszki, Natália Tőkési, Daniel Pinkas, Eszter Házy, Olivér Pavela, Andrea Bodor, Zoltán Varga, István Mándity, Mihály Kovács, Csaba Pál, Kata Horváti, Judit Tóth, Tamás Beke‐Somfai   +21 more
wiley   +1 more source

Kinetic resolution of substituted amido[2.2]paracyclophanes via asymmetric electrophilic amination

Nature Communications, 2023
Planar chiral [2.2]paracyclophane derivatives are a type of structurally intriguing and practically useful chiral molecules, which have found a range of important applications in the field of asymmetric catalysis and material science.
Shaoze Yu, Hanyang Bao, Dekun Zhang, Xiaoyu Yang   +3 more
doaj   +1 more source

Construction of Non-Biaryl Atropisomeric Amide Scaffolds Bearing a C–N Axis via Enantioselective Catalysis

Molecules, 2022
The significant scaffold offered by atropisomeric amides with a C–N chiral axis has been extensively utilized for pharmaceuticals, agricultural science, and organic syntheses.
Xiao Xiao, Biao Chen, Yi-Ping Yao, Hai-Jie Zhou, Xu Wang, Neng-Zhong Wang, Fen-Er Chen   +6 more
doaj   +1 more source

Ruthenium-Catalyzed Asymmetric Hydrohydroxyalkylation of Butadiene: The Role of the Formyl Hydrogen Bond in Stereochemical Control [PDF]

, 2015
The catalyst generated in situ from RuH$_2$(CO)(PPh$_3$)$_3$, ($S$)-SEGPHOS, and a chiral phosphoric acid promotes asymmetric hydrohydroxyalkylation of butadiene and affords enantioenriched $\alpha$-methyl homoallylic alcohols.
Grayson, MN, Houk, KN, Krische, MJ
core   +2 more sources

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Diastereo- and atroposelective synthesis of N-arylpyrroles enabled by light-induced phosphoric acid catalysis

Nature Communications, 2023
The C−N axially chiral N-arylpyrrole motifs are privileged scaffolds in numerous biologically active molecules and natural products, as well as in chiral ligands/catalysts.
Lei Dai, Xueting Zhou, Jiami Guo, Xuan Dai, Qingqin Huang, Yixin Lu   +5 more
doaj   +1 more source

Atroposelective Construction of Axially Chiral Tetraarylethenes Via NHC‐Catalyzed Desymmetrization

Advanced Science, EarlyView.
We report the first NHC‐catalyzed atroposelective synthesis of axially chiral TAEs via oxidative desymmetrization of prochiral TAE dialdehydes. This catalytic strategy operates under mild conditions and accommodates a broad range of phenolic and nitrogen nucleophiles, delivering diverse axially chiral TAEs in good yields and up to 99% ee.
Yang‐Ze Zheng, Ting‐Rui Luan, Ming‐Hao Song, Zhaofeng Sun, Chuan‐Jun Lu, Long‐Long Xi, Ren‐Rong Liu   +6 more
wiley   +1 more source

Dynamic foldamer chemistry [PDF]

, 2016
Foldamers can be made more than pieces of static, conformationally uniform molecular architecture by designing into their structure the conformational dynamism characteristic of functional molecular machines.
Amit, Azeroual, Azzarito, Berthelot, Boddaert, Brioche, Brodsky, Brown, Brown, Bryden A. F. Le Bailly, Bunkóczi, Byrne, Chouaieb, Clayden, Clayden, Cornelissen, Crisma, Dawkins, De Poli, De Poli, De Poli, De Zotti, Dolain, Dumitru, Dunitz, Fletcher, Formaggio, Fuxreiter, Gan, Gellman, Granier, Green, Ha, Habchi, Hecht, Hill, Huc, Hummel, Inai, Inai, Inai, Inai, Inai, Inai, Ishikawa, Ito, James, Jonathan Clayden, Jones, Juwarker, Kolomiets, Komori, Le Bailly, Le Bailly, Le Bailly, Lehn, Lehn, Lettieri, Maeda, Mamiya, Manglik, Müller, Nakano, Nicolaou, Okino, Orcel, Ousaka, Ousaka, Ousaka, Pengo, Perutz, Pijper, Pijper, Pike, Prasad, Prince, Qi, Reggelin, Saraogi, Smaldone, Smith, Solà, Solà, Suginome, Tomsett, Toniolo, Toniolo, Toniolo, Toniolo, Ute, Whitesides, Yashima, Yashima, Yashima, Yonath, Zhang, Zhang   +96 more
core   +3 more sources

Asymmetric Friedel-Crafts Alkylation of Indole with Chalcones Catalyzed by Chiral Phosphoric Acids

Molecules, 2009
The reaction of indole with chalcones, to give Michael-type adducts, was found to occur with good efficiency (up to 98% yield) and moderate enantioselectivity (up to 52% e.e.) in the presence of a chiral BINOL-based phosphoric acid.
Maria Rosaria Acocella, Rosaria Villano, Arrigo Scettri   +2 more
doaj   +1 more source