Results 51 to 60 of about 2,722 (150)

Enantio-, atrop-, and diastereoselective macrolactonization to access type III cyclophanes

Nature Communications
Although chiral substituents have been incorporated into ansa chains to stabilize the conformations of cyclophanes and modulate the biological activities of pharmaceuticals, the asymmetric syntheses of these atropisomers relies on substrate-induced ...
Jiaming Wang, Kang Lv, Yilu Wen, Tao Liu, Changgui Zhao   +4 more
doaj   +1 more source

Control of Multiple Stereogenic Elements in Diaryl Ethers

ChemistryEurope
We report a chiral phosphoric acid (CPA)‐catalyzed desymmetrizing aminoacetalization strategy of proaxially chiral dialdehydes that enables the construction of diaryl ethers bearing both central and axial chirality.
Abdelati Naghim, Pandidurai Solai, Michel Giorgi, Jean‐Valère Naubron, Stéphane Humbel, Radhika Gupta, Jean Rodriguez, Olivier Chuzel, Gaëlle Chouraqui, Damien Bonne   +9 more
doaj   +1 more source

Molybdenum‐Catalyzed Asymmetric Amination of α‐Hydroxy Esters: Synthesis of α‐Amino Acids

Advanced Science
Unnatural α‐amino acids are found in a wide variety of bioactive compounds ranging from proteins to pharmaceutical agents to materials science. As a result, the investigation of efficient and simple methods for their synthesis is a major purpose in ...
Shahida Perveen, Tahir Rahman, Tariq Ali, Lingyun Wang, Junjie Zhang, Ajmal Khan   +5 more
doaj   +1 more source

Organocatalyzed diastereo- and enantioselective synthesis of N–N atropisomeric isoindolinones bearing central chirality

Nature Communications
Methods for catalytically constructing of N–N axially chiral scaffolds have garnered significant attention since such compounds are widely present in natural products, bioactive molecules, and organic materials.
Xingguang Li, Xin-Ze Wang, Boming Shen, Qian-Yu Chen, Huijing Xiang, Peiyuan Yu, Pei-Nian Liu   +6 more
doaj   +1 more source

Endo-Functionalized Cyclic Oligophenylenes: Synthesis and Complexation with a Chiral Phosphoric Acid. [PDF]

ACS Omega, 2022
Ono K, Tanaka Y, Sugimoto K, Kinubari S, Kawai H.   +4 more
europepmc   +1 more source

Catalytic enantioselective synthesis of azahelicenes via cascade Pictet-Spengler reaction and dehydrogenative aromatization

Nature Communications
The introduction of N-heteroaromatic rings like pyridine and pyrrole into the helicene scaffold can significantly impact the electronic properties, redox potentials and coordination abilities of helicenes, which lead to diverse and intriguing ...
Tianren Qin, Wansen Xie, Xiaoyu Yang
doaj   +1 more source

Data Science Enables the Development of a New Class of Chiral Phosphoric Acid Catalysts. [PDF]

Chem, 2023
Liles JP, Rouget-Virbel C, Wahlman JLH, Rahimoff R, Crawford JM, Medlin A, O'Connor V, Li J, Roytman VA, Toste FD, Sigman MS.   +10 more
europepmc   +1 more source

MATEO: intermolecular α-amidoalkylation theoretical enantioselectivity optimization. Online tool for selection and design of chiral catalysts and products

Journal of Cheminformatics
The enantioselective Brønsted acid-catalyzed α-amidoalkylation reaction is a useful procedure is for the production of new drugs and natural products.
Paula Carracedo-Reboredo, Eider Aranzamendi, Shan He, Sonia Arrasate, Cristian R. Munteanu, Carlos Fernandez-Lozano, Nuria Sotomayor, Esther Lete, Humberto González-Díaz   +8 more
doaj   +1 more source

Dynamic Kinetic Stereoselective Glycosylation via Rh^II and Chiral Phosphoric Acid-Cocatalyzed Carbenoid Insertion to the Anomeric OH Bond for the Synthesis of Glycoconjugates. [PDF]

Angew Chem Int Ed Engl, 2023
Wu J, Jia P, Kuniyil R, Liu P, Tang W.
europepmc   +1 more source

A Mechanistic Study of Asymmetric Transfer Hydrogenation of Imines on a Chiral Phosphoric Acid Derived Indium Metal-Organic Framework. [PDF]

Molecules, 2022
Li X, Fan T, Wang Q, Shi T.
europepmc   +1 more source