The Emergence of Quinone Methides in Asymmetric Organocatalysis [PDF]
Molecules, 2015 Quinone methides (QMs) are highly reactive compounds that have been defined as “elusive” intermediates, or even as a “synthetic enigma” in organic chemistry.
Mariafrancesca Fochi, Luca Bernardi
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Advances in asymmetric organocatalysis over the last 10 years [PDF]
Nature Communications, 2020 Organocatalysis has become a major pillar of (asymmetric) catalysis. Here, the authors discuss recent trends in organocatalytic activation modes for challenging stereoselective transformations and the emerging integration with other fields, such as ...
Shao-Hua Xiang, Bin Tan
doaj +3 more sources
Mechanochemistry assisted asymmetric organocatalysis: A sustainable approach [PDF]
Beilstein Journal of Organic Chemistry, 2012 Ball-milling and pestle and mortar grinding have emerged as powerful methods for the development of environmentally benign chemical transformations. Recently, the use of these mechanochemical techniques in asymmetric organocatalysis has increased.
Pankaj Chauhan, Swapandeep Singh Chimni
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New advances in asymmetric organocatalysis [PDF]
Beilstein Journal of Organic Chemistry, 2022 Radovan Šebesta
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Asymmetric Organocatalysis: A Survival Guide to Medicinal Chemists [PDF]
Molecules, 2022 Majority of drugs act by interacting with chiral counterparts, e.g., proteins, and we are, unfortunately, well-aware of how chirality can negatively impact the outcome of a therapeutic regime.
Efraim Reyes +2 more
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Flipping the Card With Enantiodivergent Organocatalysis. [PDF]
ChemistryThis minireview elaborates on recent organocatalytic strategies for achieving enantiodivergence—the ability to access both product enantiomers using a single chiral catalyst. It highlights how achiral stimuli, such as solvent polarity and chemical additives, along with minimal catalyst modifications, trigger stereochemical inversions in reactions ...
Iapadre D +3 more
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Beyond canonical asymmetric induction in phosphine organocatalysis [PDF]
RSC AdvancesPhosphine organocatalysis has emerged as a formidable and transformative platform for engineering reaction manifolds that depart from classical models of asymmetric induction, enabling cascade cyclizations to proceed through distinctive stereoelectronic ...
Archana Vijayakumar +4 more
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Underexplored Catalysts as General Structures: Application of Machine Learning Techniques for Reaction-Specific Datasets. [PDF]
Angew Chem Int Ed EnglBias‐aware machine learning identified an underexplored imidazolidinone catalyst with broad competitive performance in iminium‐based reactions. Experimental benchmarking shows how data‐driven prioritization can uncover overlooked catalyst scaffolds from sparse and historically biased literature data.
Li J +4 more
europepmc +3 more sources
Enantioselective cyclization reactions involving 3-isothiocyanato oxindoles: synthesis of spirocycles [PDF]
RSC AdvancesRecently, 3-isothiocyanato oxindoles have been used in various asymmetric cascade cyclization reactions for the synthesis of biologically important spirocyclic compounds.
Mohammad Hadi Edareh +4 more
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Enantioselective radical chemistry: a bright future ahead [PDF]
Beilstein Journal of Organic ChemistryThis perspective is focused on enantioselective free radical reactions. It describes several important catalytic asymmetric strategies applied to enantioselective radical reactions, including chiral Lewis acid catalysis, organocatalysis, photoredox ...
Anna C. Renner +3 more
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