Results 191 to 200 of about 10,800 (238)
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Construction of Axially Chiral Styrenes Linking an Indole Moiety by Chiral Phosphoric Acid
The Journal of Organic Chemistry, 2022Herein we report a chiral phosphoric acid-catalyzed intermolecular C2 Friedel-Crafts alkylation reaction between ortho-alkynylnaphthols and various 3-substituted indoles, affording axially chiral alkenes with up to 93% yields (E/Z > 20:1) and up to 98% ee under mild reaction condition.
Wenxuan Zhang +3 more
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Enantioselective Bromocyclization of Olefins Catalyzed by Chiral Phosphoric Acid
Organic Letters, 2011A chiral phosphoric acid catalyzed enantioselective bromocyclization of olefins is described. Various cis-, trans-, or trisubstituted γ-hydroxy-alkenes and γ-amino-alkenes can cyclize under the reaction conditions to give optically active 2-substituted tetrahydrofurans and tetrahydropyrroles in up to 91% ee.
Deshun, Huang +6 more
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Chiral Phosphoric Acid-Catalyzed Remote Control of Axial Chirality at Boron–Carbon Bond
Journal of the American Chemical Society, 2021The previously elusive catalytic enantioselective construction of axially chiral B-aryl-1,2-azaborines with a C-B stereogenic axis has been realized through a chiral phosphoric acid-catalyzed desymmetrization strategy reported herein. The electrophilic aromatic substitution reaction of 3,5-disubsituted phenols with diazodicarboxamides could afford ...
Junxian Yang +8 more
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Axially Chiral Cyclic Phosphoric Acid Enabled Enantioselective Sequential Additions
Organic Letters, 2019Efficient axially chiral cyclic phosphoric acid catalyzed enantioselective sequential additions of 2-aryl-3 H-indol-3-ones, aldehydes, and diethyl 2-aminomalonate have been developed, and a new type of nitrogen-containing heterocyclic compounds, 2,3-dihydro-1 H-imidazo[1,5- a]indol-9(9a H)-one derivatives, were prepared in good yields and excellent ee ...
Xi Yuan +7 more
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An update on chiral phosphoric acid organocatalyzed stereoselective reactions
Organic & Biomolecular Chemistry, 2023This review article presents an in-depth analysis of the strategies and methodologies for using chiral phosphoric acids as organocatalysts in asymmetric syntheses from recent literature.
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Which Is the Actual Catalyst: Chiral Phosphoric Acid or Chiral Calcium Phosphate?
Angewandte Chemie, 2010A highly enantioselective direct Mannich-type reaction of aldimines with a broad range of 1,3-dicarbonyl compounds with the use of a chiral phosphoric acid in the presence or absence of Ca(II) is demonstrated.
Manabu, Hatano +3 more
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Chiral Spirocyclic Phosphoric Acids and Their Growing Applications
Chinese Journal of Chemistry, 2021AbstractChiral spirocyclic phosphoric acids (SPAs) are introduced in 2010 and have been versatile catalysts capable of promoting a wide range of asymmetric organocatalytic reactions, such as multi‐component reactions, Friedel–Crafts reactions, Pictet–Spengler reactions, Fischer indolizations, cycloaddition reactions, desymmetrization reactions ...
Xufeng Lin +3 more
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Computational and Theoretical Chemistry, 2014
Abstract ONIOM method was used to investigate the mechanism of chiral phosphoric acid-catalyzed Friedel–Crafts reactions of pyrrole derivatives and imines. In the reaction of imine with pyrrole, regarding to the step of the regeneration of the chiral phosphoric acid catalyst has not been discussed in details.
Chunhui Liu +3 more
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Abstract ONIOM method was used to investigate the mechanism of chiral phosphoric acid-catalyzed Friedel–Crafts reactions of pyrrole derivatives and imines. In the reaction of imine with pyrrole, regarding to the step of the regeneration of the chiral phosphoric acid catalyst has not been discussed in details.
Chunhui Liu +3 more
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Chiral phosphoric acid catalyzed redox deracemization of triarylmethanes
Chemical Synthesis, 2023Described here is the first deracemization of triaryl-substituted carbon stereocenters, which is in contrast to the well-established processes to deracemize monoaryl- and diaryl-substituted ones. This one-pot redox process involves in situ generation of a para-quinone methide intermediate followed by asymmetric reduction by chiral phosphoric acid ...
Liu, Chang +3 more
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Chiral Phosphoric Acid‐Catalyzed Atroposelective Synthesis of Axially Chiral Aminophosphines
Chinese Journal of ChemistryComprehensive SummaryP,N‐Atropisomers are valuable structural motifs, widely utilized as chiral ligands and in various catalytic systems. However, the asymmetric synthesis of these compounds from readily available starting materials remains a significant challenge.
Zi‐Han Wang +5 more
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