Results 141 to 150 of about 5,957 (202)
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Chromatography on chiral stationary phases
Journal of Materials Chemistry, 1997An overview is given of the development of the variety of chiral stationary phase materials that are available today for the direct separation of enantiomers by different chromatographic methods. Applications of these range from trace analytical determinations of enantiomeric composition in biological materials to large scale preparative isolation of ...
Stig Allenmark, Volker Schurig
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Chiral stationary phase designed for β-blockers
Journal of Chromatography A, 1991A chiral stationary phase (CSP) derived from an N-3,5-dinitrobenzoyl-alpha-amino phosphonate was prepared for the direct separation of the enantiomers of underivatized beta-blockers. Structure-chromatographic activity relationships for beta-blockers and closely related analogues are reported for this CSP and are found to be consistent with the model ...
W H, Pirkle, J A, Burke
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Comparison of monomeric and polymeric chiral stationary phases
Journal of Chromatography A, 2003Two-type polymeric chiral stationary phases (pCSPs) were prepared by surface grafting of chiral acryl-type monomers on a silica gel surface modified with 3-(trimethoxysilyl)propylmethacrylate. The prepared pCSPs were characterized by IR, Fr-Raman, scanning electron microscopy, and elemental analysis.
Kwang-Pill, Lee +8 more
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Advances in polymer materials as chiral stationary phase
Chinese Journal of Chromatography, 2016The applications of chiral drugs had a profound impact on human health. With the development of disciplines of chemistry, materials and life science, the research on the separation and analysis of chiral drugs became intensified. Chromatography and the selection of chiral stationary phase played important roles in resolving chiral drugs.
Rongji, Dai +5 more
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Journal of Chromatographic Science, 2023
Abstract Chiral sulfoximines have significant roles in pharmaceutical industry and agricultural chemicals. Furthermore, chiral structurally related sulfoximines are used for their wide potential applications in some uncharted territory. However, chromatographic study on these compounds has not been systematically performed.
Qinqin Tang, Ping Zhao, Qingle Zeng
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Abstract Chiral sulfoximines have significant roles in pharmaceutical industry and agricultural chemicals. Furthermore, chiral structurally related sulfoximines are used for their wide potential applications in some uncharted territory. However, chromatographic study on these compounds has not been systematically performed.
Qinqin Tang, Ping Zhao, Qingle Zeng
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Research progress of bonded chiral stationary phases
Chinese Journal of Chromatography, 2017Chiral separation is important in biological medicine and other fields. High performance liquid chromatography (HPLC) is widely used in chiral separation and analysis for its economic, rapid and efficient characteristics. Chiral stationary phase (CSP) is the key to achieve chiral resolution in HPLC.
Jiao, Chen, Hao, Shi
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Solution‐phase synthesis and evaluation of tetraproline chiral stationary phases
Chirality, 2012AbstractA protocol was developed for the solution‐phase synthesis of multigram amounts of two 9‐fluorenylmethoxycarbonyl (Fmoc)‐protected tetraproline peptides. These tetraproline peptides were then attached to amino derivatized silica gel. The replacement of the Fmoc group with the trimethylacetyl group lead to two tetraproline chiral stationary ...
Zhi, Dai +3 more
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Chiral Separations by HPLC on Immobilized Polysaccharide Chiral Stationary Phases
2012Immobilized polysaccharide chiral stationary phases (CSPs) are a new development in chiral chromatography with increasing importance for the resolution of racemic compounds. These CSPs can be used with solvents traditionally applied for the classical coated polysaccharide CSPs as well as solvents that were "forbidden" for the coated phases such as ...
Imran, Ali +2 more
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Chiral stationary phases on a crystalline support
Mikrochimica Acta, 1996For direct HPLC resolution of enantiomers of optically active substances, supports having an optically pure organic layer with a high order of chirality are advantageous. To ensure this, the support itself has to possess a structure of well-defined regularity. For this reason, zeolite A, a material of crystalline character has been used as support, for
Lujza P. Szab� +2 more
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Effects of temperature on retention of chiral compounds on a ristocetin A chiral stationary phase
Journal of Chromatography A, 2002The isocratic retention of enantiomers of chiral analytes, i.e. tryptophan, 1,2,3,4-tetrahydroisoquinoline and gamma-butyrolac tone analogs, was studied on a ristocetin A chiral stationary phase at different temperatures and with different mobile phase compositions, using the reversed-phase, polar-organic and normal-phase modes.
Antal, Péter +2 more
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