Results 201 to 210 of about 4,646,169 (243)
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Chiral stationary phases in HPLC for the stereoselective determination of methadone
Chirality, 1999An extensive study of the behavior of three chiral stationary phases (CSP) is presented for the stereoselective determination of methadone. The following chromatographic columns were selected: a cellulose, Chiralcel OJ; a modified cyclodextrin. Cyclobond I 2000 RSP, and a protein, Chiral-AGP.
Rudaz, Serge, Veuthey, Jean-Luc
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Derivatized vancomycin stationary phases for LC chiral separations
Talanta, 1996In this work, synthetic and natural chiral selectors were combined to form two different chiral stationary phases (CSPs). These were made by bonding R- or S-(1-naphthylethyl) carbamate (R-NEC or S-NEC)-derivatized vancomycin molecules to a silica gel support. The two CSPs were evaluated using a set of 60 enantiomeric pairs. The results were compared to
A, Berthod +3 more
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HPLC Enantioseparation on Cyclodextrin-Based Chiral Stationary Phases
2012Cyclodextrin-bonded silica material is one of the most commonly used chiral stationary phases in liquid chromatography for pharmaceutical analysis and enantioseparations. The approaches for immobilization of cyclodextrins onto the silica surface influence both, the stability of the chiral stationary phase and the enantioselectivity. In this chapter, we
Yong, Wang, Siu Choon, Ng
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Facile Diastereoseparation of Glycosyl Sulfoxides by Chiral Stationary Phase
Chirality, 2016AbstractSeparation of the diastereomers of glycosyl sulfoxides differing in the sulfur chirality has been difficult. This article presents a fast and scalable method for their diastereoseparation using a chiral stationary phase. The usefulness of this method was demonstrated in a 500‐mg scale separation within 20 min, and in the separation of ...
Tohru, Taniguchi +5 more
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Chirality
ABSTRACTInclusion complexation, hydrogen bonds, π–π interaction, dipole–dipole interaction, and steric hindrance effect all contribute to the enantioseparation ability of cyclodextrin (CD) or CD derivatives. In this work, one native cationic CD chiral stationary phases (SHCDCSP) and four derivatized CD‐CSPs, namely, per(4‐trifluoromethyl ...
Xiaoxuan Li +3 more
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ABSTRACTInclusion complexation, hydrogen bonds, π–π interaction, dipole–dipole interaction, and steric hindrance effect all contribute to the enantioseparation ability of cyclodextrin (CD) or CD derivatives. In this work, one native cationic CD chiral stationary phases (SHCDCSP) and four derivatized CD‐CSPs, namely, per(4‐trifluoromethyl ...
Xiaoxuan Li +3 more
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Chiral stationary phase design
Journal of Chromatography A, 1993William H. Pirkle, Patrick G. Murray
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Antibody-Mimicking Polymers as Chiral Stationary Phases in HPLC
Analytical Chemistry, 1996Antibody-mimicking synthetic polymers, selective for various optically active amino acid derivatives and peptides, were prepared by noncovalent molecular imprinting. A novel approach, in which the branched, trifunctional cross-linkers pentaerythritol triacrylate and 2,2-bis(hydroxymethyl)butanol trimethacrylate were copolymerized with methacrylic acid,
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Chiral stationary phases for the liquid chromatographic separation of pharmaceuticals
Journal of Pharmaceutical and Biomedical Analysis, 1988Biological systems exhibit remarkable enantioselectivity which is important in biosynthesis, metabolism, storage and transport processes. It is, therefore, not surprising that the chirality of, for example, pharmaceuticals, pesticides and agrochemicals, has become the focus of extensive research in many laboratories throughout the world.
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Synthesis and Spectroscopic Evaluation of Chiral Selectors in Crial Stationary Phases
2005The enhanced demand for enantiomerically pure compounds (EPC) has led to the development of a variety of enantioselective separation methods. Like very useful one emerged liquid chromatography which use chiral stationary phases (CSPs). One of the most used CSPs named brush or Pirkle type CSPs consist of small optically active compounds covalently bound
Kontrec, Darko +2 more
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Recent Advances in Chiral Liquid Chromatography Stationary Phases for Pharmaceutical Analysis
Journal of Chromatography A, 2023Hongdeng Qiu, Huifeng Liu
exaly