Chitin Triggers Tissue-Specific Immunity in Wheat Associated With Fusarium Head Blight
Frontiers in Plant Science, 2022 Fusarium graminearum is one of the primary causal agents of Fusarium head blight (FHB) on wheat and barley. FHB reduces grain yield and contaminates grain with various mycotoxins, including deoxynivalenol (DON).
Guixia Hao +2 more
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Phytopathology Research, 2023 Fungal pathogens are among the main destructive microorganisms for crops and ecosystems worldwide, causing substantial agricultural and economic losses.
Lei Pi +5 more
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Chitin induces accumulation in tissue of innate immune cells associated with allergy [PDF]
Nature, 2007 Allergic and parasitic worm immunity is characterized by infiltration of tissues with interleukin (IL)-4- and IL-13-expressing cells, including T-helper-2 cells, eosinophils and basophils. Tissue macrophages assume a distinct phenotype, designated alternatively activated macrophages.
Tiffany A, Reese +6 more
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TLR-2 and IL-17A in Chitin-Induced Macrophage Activation and Acute Inflammation [PDF]
The Journal of Immunology, 2008 Abstract Chitin is a ubiquitous polysaccharide in fungi, insects, and parasites. To test the hypothesis that chitin is an important immune modulator, we characterized the ability of chitin fragments to regulate murine macrophage cytokine production in vitro and induce acute inflammation in vivo. In this study, we show that chitin is a
Carla A, Da Silva +4 more
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Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice [PDF]
, 2017 This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy.
Azuma, Kazuo +43 more
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Scientific Reports, 2021 Exposure to various antigens derived from house dust mites (HDM) is considered to be a risk factor for development of certain allergic diseases such as atopic asthma, atopic dermatitis, rhinitis and conjunctivitis.
Ken Arae +14 more
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A structural and biochemical model of processive chitin synthesis [PDF]
, 2014 Chitin synthases (CHS) produce chitin, an essential component of the fungal cell wall. The molecular mechanism of processive chitin synthesis is not understood, limiting the discovery of new inhibitors of this enzyme class.
Ferenbach, Andrew T. +3 more
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Arabidopsis ubiquitin ligase PUB12 interacts with and negatively regulates Chitin Elicitor Receptor Kinase 1 (CERK1). [PDF]
PLoS ONE, 2017 In Arabidopsis, fungal chitin is recognized as a pathogen-associated molecular pattern (PAMP) by the chitin receptor complex containing the lysin-motif (LysM) receptor-like kinases CERK1 and LYK5.
Koji Yamaguchi +4 more
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Chitin induces upregulation of B7‐H1 on macrophages and inhibits T‐cell proliferation [PDF]
European Journal of Immunology, 2010 AbstractChitin is a highly abundant glycopolymer, which serves as structural component in fungi, arthropods and crustaceans but is not synthesized by vertebrates. However, vertebrates express chitinases and chitinase‐like proteins, some of which are induced by infection with helminths suggesting that chitinous structures may be targets of the immune ...
Claudia J, Wagner +3 more
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Nanostructural organization of naturally occurring composites - part II: silica-chitin-based biocomposites [PDF]
, 2012 Investigations of the micro- and nanostructures and chemical composition of the sponge skeletons as examples for natural structural biocomposites are of fundamental scientific relevance.
Worch, Hartmut +11 more
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