Inhibition of chitin deacetylases to attenuate plant fungal diseases
Phytopathogenic fungi secrete chitin deacetylase (CDA) to escape the host’s immunological defense during infection. Here, we showed that the deacetylation activity of CDA toward chitin is essential for fungal virulence.
Lin Liu +10 more
doaj +3 more sources
What Are the Functions of Chitin Deacetylases in Aspergillus fumigatus? [PDF]
Deacetylation of chitin by chitin deacetylases (Cda) results in the formation of chitosan. Chitosan, a polymer of β1,4 linked glucosamine, plays multiple roles in the function of the fungal cell wall, including virulence and evasion of host immune ...
Isabelle Mouyna +15 more
doaj +5 more sources
Characterization of the Effector Candidate Repertoire in the Arbuscular Mycorrhizal Fungus Rhizophagus irregularis [PDF]
The majority of terrestrial plants can interact with arbuscular mycorrhizal fungi (AMF) to form symbiotic relationships. AMF colonization not only enhances the host plant’s uptake of mineral nutrients but also improves its tolerance to biotic and abiotic
Yi Huang +4 more
doaj +2 more sources
Chitin deacetylase is the enzymes that has important role in converting chitin to chitosan. In nature, chitin is the second most abundant natural biopolymer after cellulose.
Siswa Setyahadi +2 more
doaj +1 more source
Effects of Ball Milling, Ultrosonic or Hydrochloric Acid Treatment on the Microstructure and Enzymatic Deacetylation Efficiency of Chitin [PDF]
Chitin is the second most abundant natural polysaccharide on Earth, which can be deacetylated to produce chitosan. However, due to the high crystallinity and poor solubility of chitin, its efficiency of enzymatic deacetylation is very low. To investigate
XIAO Yu, YU Hongwei, MA Aijin, SANG Yaxin, SUN Jilu
doaj +1 more source
Rational Design of a Potential New Nematicide Targeting Chitin Deacetylase. [PDF]
In a previously published study, the authors devised a molecular topology QSAR (quantitative structure−activity relationship) approach to detect novel fungicides acting as inhibitors of chitin deacetylase (CDA).
Galvez-Llompart M +9 more
europepmc +3 more sources
Chitin Deacetylases: Properties and Applications [PDF]
Chitin deacetylases, occurring in marine bacteria, several fungi and a few insects, catalyze the deacetylation of chitin, a structural biopolymer found in countless forms of marine life, fungal cell and spore walls as well as insect cuticle and peritrophic matrices.
Zhao, Yong +2 more
openaire +3 more sources
Chitin Deacetylases: Structures, Specificities, and Biotech Applications [PDF]
Depolymerization and de-N-acetylation of chitin by chitinases and deacetylases generates a series of derivatives including chitosans and chitooligosaccharides (COS), which are involved in molecular recognition events such as modulation of cell signaling and morphogenesis, immune responses, and host-pathogen interactions.
Laia Grifoll-Romero +4 more
openaire +2 more sources
Chitin modulates innate immune responses of keratinocytes. [PDF]
Chitin, after cellulose the second most abundant polysaccharide in nature, is an essential component of exoskeletons of crabs, shrimps and insects and protects these organisms from harsh conditions in their environment.
Korting, Hans Christian +14 more
core +2 more sources
A structural and biochemical model of processive chitin synthesis [PDF]
Chitin synthases (CHS) produce chitin, an essential component of the fungal cell wall. The molecular mechanism of processive chitin synthesis is not understood, limiting the discovery of new inhibitors of this enzyme class.
Ferenbach, Andrew T. +3 more
core +1 more source

