Genomics and Chlamydial Persistence
mBio, 2019 We read with interest the recent paper by Somboonna and colleagues, addressing changes to tryptophan synthase in a single Chlamydia trachomatis strain that had an aberrant growth phenotype in vitro (1). This strain was isolated four times, over 4 years, from a patient who was apparently persistently infected. This strain was highly related to a serovar
Dan D. Rockey +2 more
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Porcine Epidemic Diarrhea Virus (PEDV) co-infection induced chlamydial persistence/stress does not require productive viral replication [PDF]
Frontiers in Cellular and Infection Microbiology, 2014 Chlamydiae may exist at the site of infection in an alternative replicative form, called the aberrant body (AB). AB are produced during a viable but non-infectious developmental state termed persistence or chlamydial stress.
Nicole eBorel, Robert V Schoborg
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Imbalanced oxidative stress causes chlamydial persistence during non-productive human herpes virus co-infection. [PDF]
PLoS ONE, 2012 Both human herpes viruses and Chlamydia are highly prevalent in the human population and are detected together in different human disorders. Here, we demonstrate that co-infection with human herpes virus 6 (HHV6) interferes with the developmental cycle ...
Bhupesh K Prusty +6 more
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Spatial constraints within the chlamydial host cell inclusion predict interrupted development and persistence [PDF]
BMC Microbiology, 2008 Background The chlamydial developmental cycle involves the alternation between the metabolically inert elementary body (EB) and the replicating reticulate body (RB).
Bavoil Patrik M +3 more
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Beta lactamase-producing Neisseria gonorrhoeae alleviates Amoxicillin-induced chlamydial persistence in a novel in vitro co-infection model [PDF]
Current Research in Microbial Sciences, 2023 Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) cause most bacterial sexually transmitted infections (STIs) worldwide. Epidemiological studies have shown high percentages of co-infections with CT/NG and indicate that NG co-infection can ...
Delia Onorini +3 more
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Reply to Rockey et al., “Genomics and Chlamydial Persistence
mBio, 2019 In addressing the letter to the editor by Rockey et al. (1), it is important to correct the statement “…patients can be colonized by C. trachomatis.” Chlamydia trachomatis does not colonize humans but infects them. The authors’ earlier paper (2) described five patients that had apparent reinfection and/or persistent infection over a few years despite ...
Deborah Dean +4 more
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The danger signal adenosine induces persistence of chlamydial infection through stimulation of A2b receptors. [PDF]
PLoS ONE, 2009 Infections with intracellular bacteria such as chlamydiae affect the majority of the world population. Infected tissue inflammation and granuloma formation help contain the short-term expansion of the invading pathogen, leading also to local tissue ...
Matthew A Pettengill +2 more
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Mixed infections with
BMC Microbiology, 2010 Background Chlamydiae induce persistent infections, which have been associated with a wide range of chronic diseases in humans and animals. Mixed infections with Chlamydia and porcine epidemic diarrhea virus (PEDV) may result in generation of persistent ...
Kaiser Carmen +5 more
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The protease inhibitor JO146 demonstrates a critical role for CtHtrA for Chlamydia trachomatis reversion from penicillin persistence [PDF]
Frontiers in Cellular and Infection Microbiology, 2013 The Chlamydia trachomatis serine protease HtrA (CtHtrA) has recently been demonstrated to be essential during the replicative phase of the chlamydial developmental cycle.
Vanissa Abtina Ong +7 more
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Golgi fragmentation and sphingomyelin transport to Chlamydia trachomatis during penicillin-induced persistence do not depend on the cytosolic presence of the chlamydial protease CPAF. [PDF]
PLoS ONE, 2014 Chlamydia grows inside a cytosolic vacuole (the inclusion) that is supplied with nutrients by the host through vesicular and non-vesicular transport. It is unclear in many respects how Chlamydia organizes this transport.
Stephanie Dille +6 more
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