Results 81 to 90 of about 272,351 (288)

Enantiomerically Enriched Aziridine‐2‐carboxylates via Copper‐Catalyzed Reductive Kinetic Resolution of 2H‐Azirines

open access: yesAngewandte Chemie International Edition, Accepted Article.
We present the first reductive kinetic resolution of racemic 2H‐azirines to prepare optically enriched N‐H aziridine‐2‐carboxylates, which are bench stable and easily diversifiable building blocks, concomitantly with the corresponding enantiomerically enriched 2H‐azirines. The N‐H aziridines were obtained with excellent diastereoselectivity (>20:1) and
Yinuo Zheng   +3 more
wiley   +1 more source

Gene \u3cem\u3emdpC\u3c/em\u3e Plays a Regulatory Role in the Methyl-\u3cem\u3etert\u3c/em\u3e-butyl Ether Degradation Pathway of \u3cem\u3eMethylibium petroleiphilum\u3c/em\u3e Strain PM1 [PDF]

open access: yes, 2015
Among the few bacteria known to utilize methyl tert-butyl ether (MTBE) as a sole carbon source, Methylibium petroleiphilum PM1 is a well-characterized organism with a sequenced genome; however, knowledge of the genetic regulation of its MTBE degradation ...
Denison, Michael S.   +4 more
core   +1 more source

Identification of an Activity Selector for the Nitroso‐Forming Activity in Bacterial Type‐III Copper Enzymes

open access: yesAngewandte Chemie International Edition, Accepted Article.
O‐aminophenol oxidases, a specialized subclass of type‐III copper proteins, play a crucial role in the biosynthesis of bioactive nitrosophenols which display antiretroviral and blood cholesterol lowering activity. Another related subclass of type‐III copper proteins, tyrosinases, closely resemble o‐aminophenol oxidases both structurally and ...
Hoa Le Xuan, Felix Panis, Annette Rompel
wiley   +1 more source

TiO2-assisted photocatalytic degradation of diclofenac, metoprolol, estrone and chloramphenicol as endocrine disruptors in water

open access: yesAdsorption, 2013
The photocatalytic oxidation of diclofenac, metoprolol, estrone and chloramphenicol was tested in the tube reactor using different commercially available TiO2. The photocatalysts were characterized using BET, XRD and SEM.
B. Czech, K. Rubinowska
semanticscholar   +1 more source

Plasmid-Encoded Multidrug Resistance of Salmonella typhi and some Enteric Bacteria in and around Kolkata, India: A Preliminary Study [PDF]

open access: yes, 2005
The present study investigates the occurrence of R-plasmid in Salmonella typhi isolates from enteric fever cases in and around Kolkata (1991-2001), India following in vitro conjugation experiments, isolation of plasmid DNAs and agarose gel ...
Mandal, Mr. Shyamapada   +2 more
core  

Multidrug-resistant Escherichia coli, Klebsiella pneumoniae and Staphylococcus spp. in houseflies and blowflies from farms and their environmental settings [PDF]

open access: yes, 2019
Background: Antimicrobial resistance is rising globally at an alarming rate. While multiple active surveillance programs have been established to monitor the antimicrobial resistance, studies on the environmental link to antimicrobial spread are lacking.
Adekanmbi, Folesade   +10 more
core   +1 more source

Biofunctional Nanodot Arrays in Living Cells Uncover Synergistic Co‐Condensation of Wnt Signalodroplets

open access: yesSmall, Volume 18, Issue 50, December 15, 2022., 2022
High‐density arrays of biofunctionalized nanodots with diameters of 300 nm enable spatially controlled assembly of active Wnt signaling platforms in the plasma membrane. Massive parallelization at the single cell level uncovers receptor density‐dependent co‐condensation of cytosolic effector proteins, suggesting digitalized transmembrane signaling ...
Michael Philippi   +15 more
wiley   +1 more source

pH‐Directed Capture‐SELEX for Nanomolar Affinity Aptamers for Kanamycin Detection

open access: yesAnalysis &Sensing, EarlyView.
Considering the four pKa values of kanamycin A being all close to 7, two parallel SELEX experiments were carried out at pH 6 and 8. The pH 6 selection yielded a kanamycin aptamer with nanomolar affinity, which was used for fluorescent biosensor development.
Yichen Zhao, Juewen Liu
wiley   +1 more source

Folate Receptor‐Mediated Delivery of Cas9 RNP for Enhanced Immune Checkpoint Disruption in Cancer Cells

open access: yesSmall, Volume 19, Issue 2, January 11, 2023., 2023
For therapeutic genome editing, efficient and cell‐specific transport of the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated protein 9 (Cas9) system into target cells is desirable. Here, folic acid‐modified Cas9 ribonucleoprotein nanocarriers are presented, which mediate enhanced gene modification in folate receptor
Yi Lin   +8 more
wiley   +1 more source

Application of Basic Pharmacology and Dispensing Practice of Antibiotics in Accredited Drug-Dispensing Outlets in Tanzania. [PDF]

open access: yes, 2013
Provision of pharmaceutical services in accredited drug-dispensing outlets (ADDOs) in Tanzania has not been reported. This study compared the antibiotics dispensing practice between ADDOs and part II shops, or duka la dawa baridi (DLDBs), in Tanzania ...
Manyilizu, Vs, Minzi, Om
core   +1 more source

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