Results 211 to 220 of about 111,083 (256)
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Science, 1996
Miller explains in his Perspective [also see report by Malashkevich et al . ( p. 761 )] why the new pentameric coiled-coil structure of the extracellular matrix protein COMP is exciting for students of ion channels.
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Miller explains in his Perspective [also see report by Malashkevich et al . ( p. 761 )] why the new pentameric coiled-coil structure of the extracellular matrix protein COMP is exciting for students of ion channels.
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Renal Epithelial Chloride Channels
Annual Review of Physiology, 1992The renal epithelium reabsorbs about 99% of the sodium chloride filtered at the glomerulus. Until recently, the specific role of chloride in solute transport by the kidney was given little attention. Rather, chloride was considered as simply the counterion to sodium.
W B, Reeves, T E, Andreoli
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CLC chloride channels and transporters
Current Opinion in Neurobiology, 2005CLC proteins are found in cells from prokaryotes to mammals and perform functions in plasma membranes and intracellular vesicles. Several genetic human diseases and mouse models underscore their broad physiological functions in mammals. These functions range from the control of excitability to transepithelial transport, endocytotic trafficking and ...
Thomas J, Jentsch +2 more
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FUNCTION OF CHLORIDE CHANNELS IN THE KIDNEY
Annual Review of Physiology, 2005▪ Abstract Numerous Cl− channels have been identified in the kidney using physiological approaches and thus are thought to be involved in a range of physiological processes, including vectorial transepithelial Cl− transport, cell volume regulation, and vesicular acidification.
Shinichi, Uchida, Sei, Sasaki
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Chloride channels in the nuclear membrane
Journal of Membrane Biology, 1991Chloride-selective ion channels were measured from isolated rat liver nuclei. Single ion channel currents were recorded in both "nuclear-attached" and in excised patches in the inside-out configuration of the patch-clamp technique. Two types of chloride conductance were defined, a large conductance (150 pS; iCl,N) channel with complex kinetics and ...
Lucia Tabares +2 more
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Chloride channels: a state of flux
The FASEB Journal, 1995Chloride channels play important functions in different aspects of cell physiology including volume regulation, transepithelial ion transport and stabilization of membrane potential. In recent years the molecular identity of the chloride channels defective in cystic fibrosis and myotonia congenita has been elucidated, highlighting ...
M A, Valverde +2 more
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Chloride Channels in the Loop of Henle
Annual Review of Physiology, 2001▪ Abstract Cl− transport in the loop of Henle is responsible for reclamation of 25–40% of the filtered NaCl load and for the formation of dilute urine. Our understanding of the physiologic and molecular mechanisms responsible for Cl− reabsorption in both the thin ascending limb and thick ascending limb of Henle's loop has increased greatly over the ...
W B, Reeves, C J, Winters, T E, Andreoli
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Studies on Chloride Channels and their Modulators
Current Topics in Medicinal Chemistry, 2016The prime roles of mutations in the genes, encoding chloride ion channels, in various human diseases of muscle, kidney, bone and brain, such as congenital myotonia, myotonic dystrophy, cystic fibrosis, osteopetrosis, epilepsy, glioma, etc., have been well established.
Vaishali M, Patil, Satya P, Gupta
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Chloride channels in toad skin
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1982Abstract A study of the voltage and time dependence of a transepithelial Cl- current in toad skin (Bufo bufo) by the voltage-clamp method leads to the conclusion that potential has a dual role for Cl- transport. One is to control the permeability of an apical membrane Cl- pathway, the other is to drive Cl- ions through this pathway ...
Larsen, Erik Hviid, Rasmussen, B E
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Phenomics of Cardiac Chloride Channels
Comprehensive Physiology, 2013Abstract Forward genetic studies have identified several chloride (Cl − ) channel genes, including CFTR , ClC‐2 , ClC‐3, CLCA ...
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