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Amazing chloride channels: an overview
Acta Physiologica Scandinavica, 2003Abstract Aim: This review describes molecular and functional properties of the following Cl – channels: the ClC family of voltage‐dependent Cl – channels, the cAMP‐activated transmembrane conductance regulator (CFTR), Ca 2+ activated Cl – channels (CaCC) and ...
B, Nilius, G, Droogmans
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Regulation of Lymphocyte Chloride Channels
1991The chloride permeability defect which characterizes the apical membrane of secretory epithelial cells in cystic fibrosis has been difficult to study in part because of lack of accessibility of tissue for study. This problem has fostered attempts by investigators both to immortalize epithelial cell lines and to search for other cells which may serve as
P, Gardner +6 more
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The molecular biology of chloride channels
Current Opinion in Nephrology and Hypertension, 1992The molecular biology of chloride channels is a new field, having begun only 5 years ago with the cloning, on the basis of partial amino acid sequence information, of complementary DNAs for subunits of the neuronal glycine and gamma-aminobutyric acid-receptor channels.
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Chloride channels: a molecular perspective
Current Opinion in Neurobiology, 1996Plasma membrane Cl- channels perform a variety of functions, including control of excitability in neurons and muscle, cell volume regulation and transepithelial transport. Structurally, three classes of Cl- channels have been identified: ligand-gated, postsynaptic Cl- channels (e.g.
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Renal Chloride Channels in Relation to Sodium Chloride Transport
Comprehensive Physiology, 2019ABSTRACT The many mechanisms governing NaCl absorption in the diverse parts of the renal tubule have been largely elucidated, although some of them, as neutral NaCl absorption across the cortical collecting duct or regulation through with‐no‐lysine (WNK) kinases have emerged only recently. Chloride channels, which
Jacques, Teulon +5 more
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Reabsorption of Sodium Chloride — Lessons from the Chloride Channels
New England Journal of Medicine, 2004Under normal conditions, most of the sodium chloride filtered by the kidney (often more than 99 percent) is reabsorbed, and one can think of the tubular functions that permit this reabsorption as i...
Daniel G, Bichet, T Mary, Fujiwara
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Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1984
Cl- current in GABA-sensitive neurons of the frog dorsal root ganglia was separated from other Na+, Ca2+ and K+ currents using the suction pipette technique which allows internal perfusion and current clamp. Adequacy of the internal perfusion technique was assessed from the reversal potential for GABA-induced Cl- current (EGABA) at various ...
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Cl- current in GABA-sensitive neurons of the frog dorsal root ganglia was separated from other Na+, Ca2+ and K+ currents using the suction pipette technique which allows internal perfusion and current clamp. Adequacy of the internal perfusion technique was assessed from the reversal potential for GABA-induced Cl- current (EGABA) at various ...
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Chloride channels in endothelial cells
The Journal of PhysiologyAbstractEndothelial cells (ECs) line the lumen of blood and lymphatic vessels and form capillaries. ECs are exposed to a diverse array of physiological stimuli and regulate a multitude of functions, including contractility, blood coagulation, leukocyte recruitment, wound healing, angiogenesis and the blood–tissue exchange of gases, metabolites and ...
Alejandro Mata‐Daboin +2 more
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Chloride channels of intracellular organelles
Current Opinion in Cell Biology, 1995Chloride channels are present in a variety of intracellular organelles (Golgi, endosomes, endoplasmic reticulum, and sarcoplasmic reticulum) where they serve largely to shunt the membrane potential created by other ion-translocating processes. Electrophysiological studies have shown that the Cl- channels of the endoplasmic and sarcoplasmic reticula ...
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The Physiology of Epithelial Chloride Channels
Hospital Practice, 1989These highly regulated channels have a rate-limiting function in secretory activity. Recent research has suggested that the regulation of chloride transport is the likely locus of the defect in cystic fibrosis and has contributed to a fuller understanding of the control of ion channels and their role in fluid and electrolyte balance.
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