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The CLC chloride channel family
Pfl�gers Archiv European Journal of Physiology, 1999Chloride channels perform important roles in the regulation of cellular excitability, in transepithelial transport, cell volume regulation, and acidification of intracellular organelles. This variety of functions requires a large number of different chloride channels that are encoded by genes belonging to several unrelated gene families. The CLC family
T J, Jentsch +3 more
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Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1984
Cl- current in GABA-sensitive neurons of the frog dorsal root ganglia was separated from other Na+, Ca2+ and K+ currents using the suction pipette technique which allows internal perfusion and current clamp. Adequacy of the internal perfusion technique was assessed from the reversal potential for GABA-induced Cl- current (EGABA) at various ...
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Cl- current in GABA-sensitive neurons of the frog dorsal root ganglia was separated from other Na+, Ca2+ and K+ currents using the suction pipette technique which allows internal perfusion and current clamp. Adequacy of the internal perfusion technique was assessed from the reversal potential for GABA-induced Cl- current (EGABA) at various ...
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CLC chloride channels and transporters
Current Opinion in Neurobiology, 2005CLC proteins are found in cells from prokaryotes to mammals and perform functions in plasma membranes and intracellular vesicles. Several genetic human diseases and mouse models underscore their broad physiological functions in mammals. These functions range from the control of excitability to transepithelial transport, endocytotic trafficking and ...
Thomas J, Jentsch +2 more
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Chloride channels in toad skin
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1982A study of the voltage and time dependence of a transepithelial Cl- current in toad skin ( Bufo bufo ) by the voltage-clamp method leads to the conclusion that potential has a dual role for Cl- transport. One is to control the permeability of an apical membrane Cl- pathway, the other is to drive Cl- ions through ...
Larsen, Erik Hviid, Rasmussen, B E
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1998
Abstract It has become clear that chloride channels play a role in a number of different cellular functions. Until recently the γ-amino-butyric acid (GABA) and glycine-activated - receptor anion - selective channels were the only well-characterized anion channels but, following the introduction of the patch-clamp technique, it became ...
M A Valverde, S P Hardy,, A S Monaghan
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Abstract It has become clear that chloride channels play a role in a number of different cellular functions. Until recently the γ-amino-butyric acid (GABA) and glycine-activated - receptor anion - selective channels were the only well-characterized anion channels but, following the introduction of the patch-clamp technique, it became ...
M A Valverde, S P Hardy,, A S Monaghan
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Chloride channels: a molecular perspective
Current Opinion in Neurobiology, 1996Plasma membrane Cl- channels perform a variety of functions, including control of excitability in neurons and muscle, cell volume regulation and transepithelial transport. Structurally, three classes of Cl- channels have been identified: ligand-gated, postsynaptic Cl- channels (e.g.
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Regulation of Lymphocyte Chloride Channels
1991The chloride permeability defect which characterizes the apical membrane of secretory epithelial cells in cystic fibrosis has been difficult to study in part because of lack of accessibility of tissue for study. This problem has fostered attempts by investigators both to immortalize epithelial cell lines and to search for other cells which may serve as
P, Gardner +6 more
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Phenomics of Cardiac Chloride Channels
Comprehensive Physiology, 2013AbstractForward genetic studies have identified several chloride (Cl−) channel genes, including CFTR, ClC‐2, ClC‐3, CLCA, Bestrophin, and Ano1, in the heart. Recent reverse genetic studies using gene targeting and transgenic techniques to delineate the functional role of cardiac Cl− channels have shown that Cl− channels may contribute to cardiac ...
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Chloride channels of intracellular organelles
Current Opinion in Cell Biology, 1995Chloride channels are present in a variety of intracellular organelles (Golgi, endosomes, endoplasmic reticulum, and sarcoplasmic reticulum) where they serve largely to shunt the membrane potential created by other ion-translocating processes. Electrophysiological studies have shown that the Cl- channels of the endoplasmic and sarcoplasmic reticula ...
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Artificial channels for confined mass transport at the sub-nanometre scale
Nature Reviews Materials, 2021Jie Shen, Gong-Ping Liu, Yu Han
exaly