Results 61 to 70 of about 136,070 (312)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Chloride channelopathies

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009
Channelopathies, defined as diseases that are caused by mutations in genes encoding ion channels, are associated with a wide variety of symptoms. Impaired chloride transport can cause diseases as diverse as cystic fibrosis, myotonia, epilepsy, hyperekplexia, lysosomal storage disease, deafness, renal salt loss, kidney stones and osteopetrosis.
Planells-Cases, Rosa, Jentsch, Thomas J.
openaire   +3 more sources

Service life estimation of cracked and healed concrete in marine environment [PDF]

, 2016
In the aggressive seawater environment, the durability of concrete is strongly influenced by the presence of chlorides and sulfates. Marine structures mostly have an important social function with a high economic impact, which makes durability a key ...
De Belie, Nele, Maes, Mathias
core  

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Damage to concrete bridges due to reinforcement corrosion. Part I. Site investigations [PDF]

Transport, 2002
Corrosion of reinforcement initiated by concrete carbonation and chloride contamination is the most common type of deterioration of concrete bridges. Based on the author's experience a number of cases is reported in which the corrosion of ordinary and ...
Z. Kamaitis
doaj  

Durability of reinforced adobe exposed to chloride ions

Materiales de Construccion, 2006
One of the primary shortcomings of adobe, a dried mudblock stabilized with sisal hemp and cement widely used across all of Latin America, is its dimensional instability when exposed to water or aggressive environments.
R. E. Malavé, M. Gómez, G. Sosa, E. Anzola, A. Giménez   +4 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Relevance of cis- and trans-dichloride Ru intermediates in Grubbs-II olefin metathesis catalysis (H(2)IMesCl(2)Ru=CHR) [PDF]

, 2008
Using density functional theory with the B3LYP and M06 functionals, we show conclusively that the (H2IMes)(Cl)2Ru olefin metathesis mechanism is bottom-bound with the chlorides remaining trans throughout the reaction, thus attempts to effect diastereo ...
Benitez, Diego, Goddard, William A., III, Tkatchouk, Ekaterina   +2 more
core   +2 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Implications on RC structure performance of model parameter sensitivity: Effect of chlorides

Journal of Civil Engineering and Management, 2010
This paper presents a sensitivity analysis of the parameters of the model presented in the fib – Model Code for Service Life Design for corrosion initiation due to chloride penetration.
Rui Miguel Ferreira
doaj