Results 21 to 30 of about 1,700 (151)

PAK1 inhibitor NVS‐PAK1‐1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Synaptic spine loss in Alzheimer's disease (AD) contributes to cognitive decline. p21‐activated kinase 1 (PAK1), a regulator of spine integrity, is aberrantly activated in AD. We investigated whether PAK1 inhibition might preserve dendritic spines in vitro and in vivo.
Tao Yang, Hasi Huhe, Sean‐Paul Williams, Sukhneet Kaur, Yeonglong Albert Ay, Zachary W. Davis‐Gilbert, Gregory A. Cary, Carolyn Paisie, Robert R. Butler III, Jesse Wiley, Ranjita Betarbet, Haian Fu, Duc Duong, Nicholas T. Seyfried, Karina Leal, Gregory W. Carter, Aled Edwards, Allan I. Levey, Jacob L. Capener, David H. Drewry, Mohammad A. Hossain, Hans J. Oh, Alison D. Axtman, Stacey J. Sukoff Rizzo, Frank M. Longo, The Emory‐Sage‐SGC‐Jax TREAT‐AD Center   +25 more
wiley   +1 more source

Degradation of 3‐chlorobenzoate by thermophilic micro‐organisms [PDF]

Letters in Applied Microbiology, 1997
Thermophilic (75 degrees C), anaerobic biodegradation of chlorobenzoates was investigated using different inocula from geothermal and non-geothermal environments. Microbial dehalogenation of 3-chlorobenzoate (0.5 mmol l-1 was achieved by two mixed cultures growing anaerobically at 75 degrees C.
S E, Maloney, T S, Marks, R J, Sharp
openaire   +2 more sources

Exploration of Thioxolone Derivatives: Synthesis, Docking Studies, and Biological Evaluation for Antibacterial and Antidiabetic Activities

ChemistrySelect, Volume 10, Issue 38, October 13, 2025.
Thioxolone derivatives are evaluated for antibacterial and anti‐diabetic potential. Compounds T‐11, T‐12, and T‐13 exhibit potent antibacterial activity against E. coli, B. cereus, and S. aureus, with low MIC values. T‐11 and T‐3 show stronger α‐glucosidase inhibition than acarbose, while molecular docking reveals T‐13 as the strongest binder ...
Thohidjhon Khajavali SK, Satya Sree Nannapaneni, Rambabu Gundla, Naresh Kumar Katari   +3 more
wiley   +1 more source

Structurally Constrained Cyclic (Diacyloxyiodo)Arenes as an Enabling Platform for Hypervalent Iodine(III) Chemistry

Advanced Science, Volume 12, Issue 36, September 25, 2025.
We developed cyclic (diacyloxyiodo)arenes to overcome the reactivity/selectivity paradox in iodine chemistry. This new platform enables simple, one‐pot synthesis of diverse hypervalent iodine(III) reagents. The method is sustainable, catalytic, works for asymmetric reactions, and is biocompatible (e.g., modifying peptides).
Shengyu Zhong, Shaoyan Gan, Xin Zhang, Lijuan Song, Lei Shi   +4 more
wiley   +1 more source

Synthesis, Characterization, and Electrochemical Properties of Tri‐ and Tetranuclear CoIII‐Oxo Complexes

European Journal of Inorganic Chemistry, Volume 28, Issue 24, August 29, 2025.
A series of three tetranuclear and two trinuclear Co(III) carboxylate complexes are synthesized and thoroughly spectroscopically and electrochemically characterized. The relative stability of the tetranuclear versus trinuclear complexes is investigated by density functional theory calculations, and the infrared and ultraviolet/visible spectra are ...
Timo Fockenberg, Niklas Sülzner, Hatem M. A. Amin, Christoph Wölper, Christof Hättig, Stephan Schulz   +5 more
wiley   +1 more source

THERMAL DECARBOXYLATION OF CHLOROBENZOIC ACIDS

, 1956
Thermal decarboxylation of o-chloro- and 2-4-dichlorobenzoic acids in resorcinol solution follows SE2. mechanism. The activation energies, frequency factors and entropies of activation are: 32300 cals. mole -1, 6.76x1010 sec. -1 and _12.0 cals. deg.-1 for o-chlornbenzoic acid, and 27600 cals mole-1, 3.98X 109sec.-1 and _17.6 cals.
S. S. MUHAMMED, MISS AZIZ SIDDIQUI
openaire   +1 more source

An adamantane‐based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation

The FEBS Journal, Volume 292, Issue 13, Page 3449-3476, July 2025.
Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a cationic thermosensory channel crucial for cold sensation and menthol response. TRPM8 dysfunction leads to sensory symptoms such as cold allodynia. Targeting TRPM8 is important for treating diseases like peripheral neuropathies and cancer.
Angela Lamberti, Silvio Aprile, David Cabañero, Fabio Travagin, Laura Butron, Gregorio Fernández‐Ballester, Gian Cesare Tron, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel, Ubaldina Galli   +9 more
wiley   +1 more source

Ir/Ni Metallaphotoredox Catalysis for the C(sp3)─H Bond α‐Arylation and Alkylation of N‐Alkyl N‐Heterocycles

Chemistry – A European Journal, Volume 31, Issue 33, June 12, 2025.
Ir/Ni metallaphotoredox system enables the regioselective α‐arylation and alkylation of N‐alkyl heterocycles via C(sp3)─H bond functionalization. This method bypasses traditional Sn2 pathways and offers complementary regioselectivity to transition metal catalysis.
Bin Lv, Fangying Ling, Jean‐François Soulé   +2 more
wiley   +1 more source

Photoredox Autocatalysis: Towards a Library of Generally Applicable Sulfonamide Reductive Photocatalysts

Angewandte Chemie International Edition, Volume 64, Issue 22, May 26, 2025.
Photoredox autocatalysis is revealed to access cyclic biaryl sulfonamides (BASNs) without an initial exogenous photocatalyst. While unveiling photoredox autocatalysis is important to the enrichment of basic research, this has also led to further practical applications such as rapid discovery of novel, potent and readily accessible photocatalyst ...
Jaspreet Kaur, Mark John P. Mandigma, Nakul Abhay Bapat, Joshua P. Barham   +3 more
wiley   +1 more source

Exploration of Aromatic Hydrazides as Inhibitors of Human Carbonic Anhydrases

Archiv der Pharmazie, Volume 358, Issue 4, April 2025.
Hydrazide‐based derivatives were evaluated as inhibitors of human carbonic anhydrase (hCA) isoforms I, II, IV, IX, and XII. Several derivatives, particularly those with ureido‐linkers, exhibited strong inhibitory activity with inhibition constants in the low micromolar range.
German Benito Menendez, Simone Giovannuzzi, Alessandro Bonardi, Alessio Nocentini, Paola Gratteri, Claudiu T. Supuran   +5 more
wiley   +1 more source